Multiple Approaches to Address Potential Risk Factors of Chagas Disease Transmission in Northeastern Brazil

Autor(es)

Daflon-Teixeira, Natalia Faria ^{[1, 2]} ; Coutinho, Carolina ^[3] ; Gomes, Tais Ferreira ^{[1, 2]} ; Toma, Helena Keiko ^{[4, 5]} ; Duarte, Rosemere ^{[6, 7]} ; Boia, Marcio Neves ^[8] ; Carvalho-Costa, Filipe Anibal ^{[9, 10, 11]} ; Almeida, Carlos Eduardo ^[12] ; Lima, Marli Maria ^{[1, 2]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] IOC Fiocruz, Inst Oswaldo Cruz, Lab Ecoepidemiol Doenca Chagas, Rio De Janeiro - Brazil

^[2] Inst Oswaldo Cruz Fiocruz, Lab Ecoepidemiol Doenca Chagas, Av Brazil 4365, BR-21045900 Rio De Janeiro - Brazil

^[3] Inst Comunicacao & Informacao Cient & Tecnol Saud, Rio De Janeiro - Brazil

^[4] Univ Fed Rio de Janeiro UFRJ, Lab Diagnost Mol & Hematol, Rio De Janeiro - Brazil

^[5] Univ Fed Rio de Janeiro, Lab Diagnost Mol & Hematol, Rio De Janeiro - Brazil

^[6] Escola Nacl Saude Publ ENSP Fiocruz, Dept Ciencias Biol, Rio De Janeiro - Brazil

^[7] Escola Nacl Saude Publ Fiocruz, Escola Nacl Saude Publ, Dept Ciencias Biol, Rio De Janeiro - Brazil

^[8] IOC Fiocruz, Lab Biol & Parasitol Mamiferos Silvestres Reserva, Rio De Janeiro - Brazil

^[9] IOC Fiocruz, Lab Epidemiol & Sistemat Mol, Rio De Janeiro - Brazil

^[10] Fundacao Oswaldo Cruz, Escritorio Reg Fiocruz Piaui, Teresina - Brazil

^[11] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Epidemiol & Sistemat Mol, Rio De Janeiro - Brazil

^[12] Univ Estadual Campinas, UNICAMP, Inst Biol, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 100, n. 2, p. 296-302, 2019.
• Citações Web of Science: 0

Resumo

Chagas disease is one of the most significant systemic parasitosis in Latin America, caused by Trypanosoma cruzi, which is mainly transmitted by hematophagous insects, the triatomines. This research was carried out in both domestic and wild environments throughout a Northeastern rural locality. Triatomines were captured in both peridomicile and wild environments, obtaining 508 specimens of triatomines, of which 99.6% were Triatoma brasiliensis. Insects were captured in 10 (18.5%) peridomiciles with an average of 8.3 triatomines per residence. Triatoma brasiliensis nymphs and adults were found in six peridomiciles, generating a 11.1% colonization. No T. cruzi infection was detected in the 447 peridomestic insects analyzed. On the other hand, of the 55 sylvatic T. brasiliensis molecularly examined for T. cruzi, 12 (21%) were positive, all harboring T. cruzi I. The blood meal analysis by enzyme-linked immunosorbent assay from gut content revealed that both peridomestic and wild triatomine populations fed mainly on birds, refractory to the parasite, which may explain the null rate of natural infection prevalence in the domestic environment. However, infected triatomines for potential home infestation within the radius of insect dispersion capacity were registered in rock outcrops around the dwellings. Anthropogenic environmental influences are able to rapidly alter these scenarios. Therefore, to avoid disease transmission to humans, we recommend constant vector control combined with periodic serological surveillance. The associated methodology presented herein may serve as a model for early detections of risk factors for Chagas disease transmission in the Brazilian Northeast. (AU)

• Processo FAPESP: 16/08176-9 - Abordagem integrada de parâmetros morfo-moleculares para Triatoma brasiliensis, o principal vetor da Doença de Chagas no semiárido brasileiro: a elucidação de elos da cadeia ecoepidemiológica
• Beneficiário: Carlos Eduardo de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores