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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Multiple Sclerosis multimodal lesion simulation tool (MS-MIST)

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Senra Filho, Antonio Carlos da S. [1] ; Simozo, Fabricio Henrique [1] ; dos Santos, Antonio Carlos [2] ; Murta Junior, Luiz Otavio [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Dept Comp & Math, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Clin, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Citações Web of Science: 0

Background: Multiple Sclerosis (MS) diagnosis and evaluation is often a challenging task due to its growing need for multimodal MRI acquisition protocol. Recently, the scientific community offers several computational alternatives to the time-consuming and subjective task of manual MS lesion segmentation. Although there is an increasing number of MS lesion segmentation methods, a controlled and realistic simulation environment can benefit the community for a reliable evaluation procedure. Methods: This study proposes an automatic parametric MS lesion simulation framework (MS-MIST) with the objective to emulate real MS-like pattern on MRI data of healthy individuals. The voxel gray level patterns, spatial location, and shapes extracted from MS patient allow consistent simulation features. We used both visual evaluation from an expert radiologist in the field of MS diagnosis and SPM Lesion Segmentation Tool (LST) for qualitative and quantitative simulation quality, respectively. Results: Our results show that both the agreement between the automatic segmentation with the simulated lesions (Pearson's correlation R = 0.977) and the segmentation quality scores, i.e., sensitivity (mean = 0.9050), specificity (mean = 0.9992), dice similarity (mean = 0.8972), and accuracy (mean = 0.9984), are consistent between MS-MIST and real clinical settings. Conclusions: MS-MIST proposes a practical solution to common issues discussed in the literature, such as inconsistency with real lesions geometry, imprecise lesion spatial and signal variability, lack of multiple MRI modalities and restrictions to simulate different lesion loads. It is worth noting that the simulation platform is freely available as an open-source code to the community. (AU)

Processo FAPESP: 17/20598-9 - Métodos computacionais para o planejamento, avaliação e acompanhamento de cirurgias e terapias através de imagens médicas.
Beneficiário:Luiz Otavio Murta Junior
Modalidade de apoio: Auxílio à Pesquisa - Regular