Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length

Autor(es)

Tempaku, Priscila ^[1] ; Hirotsu, Camila ^{[1, 2]} ; Mazzotti, Diego ^[3] ; Xavier, Gabriela ^{[4, 5]} ; Maurya, Pawan ^{[6, 7]} ; Brielzke, Elisa ^[6] ; Belangero, Sintia ^{[4, 6, 5]} ; Poyares, Dalva ^[1] ; Bittencourt, Lia ^[1] ; Tufik, Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[2] Lausanne Univ Hosp, Ctr Invest & Res Sleep, Dept Internal Med, Lausanne - Switzerland

^[3] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA

^[4] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil

^[7] Cent Univ Haryana, Dept Biochem, Mahendergarh - India

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CLINICAL SLEEP MEDICINE; v. 14, n. 12, p. 2037-2045, 2018.
• Citações Web of Science: 3

Resumo

Study Objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample. Methods: As part of the EPISONO cohort (Sao Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. For the objective insomnia phenotype, we combined insomnia diagnosis with total sleep time from polysomnography with a cutoff of 360 minutes, allowing the classification of six groups. Self-reported sleep duration was used to classify the individuals as short (< 6 hours), average (6 to 8 hours) and long (> 8 hours) sleepers. The leukocyte telomere length was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered leukocyte telomere length < 10th percentile as short telomere and leukocyte telomere length >= 10th percentile as non-short telomere. Results: After adjusting for sex, age, and body mass index, only insomnia disorder (odds ratio {[}OR] = 2.654, 95% confidence interval {[}CI] = 1.025-6.873, P = .044), insomnia disorder total sleep time < 360 minutes (OR = 4.205, 95% CI = 1.097-16.117, P = .036) and long sleepers (OR = 2.177, 95% CI = 1.1893.987, P = .012) were associated with short telomere. Conclusions: Our findings support the existence of an association among insomnia, insomnia phenotype, and self-reported long sleep duration with the maintenance of telomere length. Commentary: A commentary on this article appears in this issue on page 1975. (AU)

• Processo FAPESP: 15/17549-0 - Avaliação objetiva do sono e do comprimento médio dos telômeros em uma amostra da cidade de São Paulo
• Beneficiário: Priscila Farias Tempaku
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/15259-2 - Epidemiologia do sono na cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
• Beneficiário: Camila Hirotsu
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado