Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length

Full text
Tempaku, Priscila [1] ; Hirotsu, Camila [1, 2] ; Mazzotti, Diego [3] ; Xavier, Gabriela [4, 5] ; Maurya, Pawan [6, 7] ; Brielzke, Elisa [6] ; Belangero, Sintia [4, 6, 5] ; Poyares, Dalva [1] ; Bittencourt, Lia [1] ; Tufik, Sergio [1]
Total Authors: 10
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[2] Lausanne Univ Hosp, Ctr Invest & Res Sleep, Dept Internal Med, Lausanne - Switzerland
[3] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA
[4] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[7] Cent Univ Haryana, Dept Biochem, Mahendergarh - India
Total Affiliations: 7
Document type: Journal article
Source: JOURNAL OF CLINICAL SLEEP MEDICINE; v. 14, n. 12, p. 2037-2045, 2018.
Web of Science Citations: 3

Study Objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample. Methods: As part of the EPISONO cohort (Sao Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. For the objective insomnia phenotype, we combined insomnia diagnosis with total sleep time from polysomnography with a cutoff of 360 minutes, allowing the classification of six groups. Self-reported sleep duration was used to classify the individuals as short (< 6 hours), average (6 to 8 hours) and long (> 8 hours) sleepers. The leukocyte telomere length was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered leukocyte telomere length < 10th percentile as short telomere and leukocyte telomere length >= 10th percentile as non-short telomere. Results: After adjusting for sex, age, and body mass index, only insomnia disorder (odds ratio {[}OR] = 2.654, 95% confidence interval {[}CI] = 1.025-6.873, P = .044), insomnia disorder total sleep time < 360 minutes (OR = 4.205, 95% CI = 1.097-16.117, P = .036) and long sleepers (OR = 2.177, 95% CI = 1.1893.987, P = .012) were associated with short telomere. Conclusions: Our findings support the existence of an association among insomnia, insomnia phenotype, and self-reported long sleep duration with the maintenance of telomere length. Commentary: A commentary on this article appears in this issue on page 1975. (AU)

FAPESP's process: 15/17549-0 - Objective sleep evaluation and mean telomere length in a sample of São Paulo city
Grantee:Priscila Farias Tempaku
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/15259-2 - Epidemiology of sleep in the city of São Paulo: follow-up of volunteers from the population-based study EPISONO
Grantee:Camila Hirotsu
Support type: Scholarships in Brazil - Post-Doctorate