| Full text | |
| Author(s): |
Tempaku, Priscila
[1]
;
Hirotsu, Camila
[1, 2]
;
Mazzotti, Diego
[3]
;
Xavier, Gabriela
[4, 5]
;
Maurya, Pawan
[6, 7]
;
Brielzke, Elisa
[6]
;
Belangero, Sintia
[4, 6, 5]
;
Poyares, Dalva
[1]
;
Bittencourt, Lia
[1]
;
Tufik, Sergio
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[2] Lausanne Univ Hosp, Ctr Invest & Res Sleep, Dept Internal Med, Lausanne - Switzerland
[3] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA
[4] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[7] Cent Univ Haryana, Dept Biochem, Mahendergarh - India
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF CLINICAL SLEEP MEDICINE; v. 14, n. 12, p. 2037-2045, 2018. |
| Web of Science Citations: | 3 |
| Abstract | |
Study Objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample. Methods: As part of the EPISONO cohort (Sao Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. For the objective insomnia phenotype, we combined insomnia diagnosis with total sleep time from polysomnography with a cutoff of 360 minutes, allowing the classification of six groups. Self-reported sleep duration was used to classify the individuals as short (< 6 hours), average (6 to 8 hours) and long (> 8 hours) sleepers. The leukocyte telomere length was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered leukocyte telomere length < 10th percentile as short telomere and leukocyte telomere length >= 10th percentile as non-short telomere. Results: After adjusting for sex, age, and body mass index, only insomnia disorder (odds ratio {[}OR] = 2.654, 95% confidence interval {[}CI] = 1.025-6.873, P = .044), insomnia disorder total sleep time < 360 minutes (OR = 4.205, 95% CI = 1.097-16.117, P = .036) and long sleepers (OR = 2.177, 95% CI = 1.1893.987, P = .012) were associated with short telomere. Conclusions: Our findings support the existence of an association among insomnia, insomnia phenotype, and self-reported long sleep duration with the maintenance of telomere length. Commentary: A commentary on this article appears in this issue on page 1975. (AU) | |
| FAPESP's process: | 15/17549-0 - Objective sleep evaluation and mean telomere length in a sample of São Paulo city |
| Grantee: | Priscila Farias Tempaku |
| Support type: | Scholarships in Brazil - Master |
| FAPESP's process: | 14/15259-2 - Epidemiology of sleep in the city of São Paulo: follow-up of volunteers from the population-based study EPISONO |
| Grantee: | Camila Hirotsu |
| Support type: | Scholarships in Brazil - Post-Doctorate |