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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Diminished cholesterol efflux mediated by HDL and coronary artery disease in young male anabolic androgenic steroid users

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Autor(es):
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de Souza, Francis Ribeiro [1] ; Dos Santos, Marcelo Rodrigues [1] ; Porello, Rafael Armani [1] ; Peixoto da Fonseca, Guilherme Wesley [1] ; Carrari Sayegh, Ana Luiza [1] ; Lima, Thais Pinheiro [1] ; Ferreira, Fabiana Dias [2] ; de Oliveira, Tiago Franco [3] ; Yonamine, Mauricio [4] ; Takayama, Liliam [5] ; Rodrigues Pereira, Rosa Maria [5] ; Negrao, Carlos Eduardo [1] ; Passarelli, Marisa [2, 6] ; Rochitte, Carlos Eduardo [1] ; de Nazare Nunes Alves, Maria Janieire [1]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Coracao InCor, Hosp Clin, Fac Med, Sao Paulo - Brazil
[2] Univ Sao Paulo, Hosp Clin, Lab Lipides LIM 10, Fac Med, Sao Paulo - Brazil
[3] Univ Fed Ciencias Saude Porto Alegre, Dept Farmacociencias, Porto Alegre, RS - Brazil
[4] Univ Sao Paulo, Dept Anal Clin & Toxicol, Fac Ciencias Farmaceut, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Hosp Clin, Lab Metab Osseo, Fac Med, Sao Paulo - Brazil
[6] Univ Nove Julho, Programa Posgrad Med, Sao Paulo, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: ATHEROSCLEROSIS; v. 283, p. 100-105, APR 2019.
Citações Web of Science: 1
Resumo

Background and aims: Anabolic androgenic steroids (AAS) have been associated with coronary artery disease (CAD). AAS abuse leads to a remarkable decrease in high-density lipoprotein (HDL) plasma concentration, which could be a key factor in the atherosclerotic process. Moreover, not only the concentration of HDL, but also its functionality, plays a pivotal role in CAD. We tested the functionality of HDL by cholesterol efflux and antioxidant capacity. We also evaluated the prevalence of CAD in AAS users. Methods: Twenty strength-trained AAS users (AASU) age 29 +/- 5 yr, 20 age-matched strength-trained AAS nonusers (AASNU), and 10 sedentary controls (SC) were enrolled in this cross-sectional study. Functionality of HDL was evaluated by C-14-cholesterol efflux and the ability of HDL in inhibiting LDL oxidation. Coronary artery was evaluated with coronary computed tomography angiography. Results: Cholesterol efflux was lower in AASU compared with AASNU and SC (20 vs. 23 vs. 24%, respectively, p < 0.001). However, the lag time for LDL oxidation was higher in AASU compared with AASNU and SC (41 vs 13 vs 11 min, respectively, p < 0.001). We found at least 2 coronary arteries with plaques in 25% of AASU. None of the AASNU and SC had plaques. The time of AAS use was negatively associated with cholesterol efflux. Conclusions: This study indicates that AAS abuse impairs the cholesterol efflux mediated by HDL. Long-term AAS use seems to be correlated with lower cholesterol efflux and early subclinical CAD in this population. (AU)

Processo FAPESP: 12/10527-3 - Impacto da auto-administração de esteroides androgênicos anabolizantes no sistema cardiovascular
Beneficiário:Maria Janieire de Nazaré Nunes Alves
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/24306-0 - O efeito da neprilisina (LCZ696) sobre a tolerância ao exercício, vasodilatação muscular, força muscular e composição corporal em pacientes com insuficiência cardíaca
Beneficiário:Marcelo Rodrigues dos Santos
Linha de fomento: Bolsas no Brasil - Pós-Doutorado