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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

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de Jong, Simone [1, 2, 3] ; Abdalla Diniz, Mateus Jose [4, 5] ; Saloma, Andiara [4, 5] ; Gadelha, Ary [4] ; Santoro, Marcos L. [6] ; Ota, Vanessa K. [4, 6] ; Noto, Cristiano [4] ; Curtis, Charlesg [1, 2, 3] ; Newhouse, Stephen J. [2, 3, 7, 8] ; Patel, Hamel [2, 3, 7] ; Hall, Lynsey S. [9] ; O'Reilly, Paul F. [1] ; Belangero, I, Sintia ; Bressan, Rodrigo A. [10] ; Breen, Gerome [1, 2, 3] ; Wray, Naomi R. [11, 12] ; Ripke, Stephan [13, 14, 15] ; Mattheisen, Manuel [16, 17, 18, 19, 20] ; Trzaskowski, Maciej [12] ; Byrne, Enda M. [12] ; Abdellaoui, Abdel [21, 22] ; Adams, Mark J. [23] ; Agerbo, Esben [24, 17, 25] ; Air, Tracy M. [26] ; Andlauer, Till F. M. [27, 28] ; Bacanu, Silviu-Alin [29] ; Baekvad-Hansen, Marie [17, 30] ; Beekman, Aartjan T. F. [31, 32] ; Bigdeli, Tim B. [29, 33] ; Binder, Elisabeth B. [27, 34] ; Blackwood, Douglas H. R. [23] ; Bryois, Julien [35] ; Buttenschon, Henriette N. [36, 17, 18] ; Bybjerg-Grauholm, Jonas [30] ; Cai, Na [37, 38] ; Castelao, Enrique [39] ; Christensen, Jane Hvarregaard [16, 17, 18] ; Clarke, Toni-Kim [23] ; Coleman, I, Jonathan R. ; Colodro-Conde, Lucia [40] ; Couvy-Duchesne, Baptiste [11, 41] ; Craddock, Nick [9] ; Crawford, Gregory E. [42, 43] ; Davies, Gail [44] ; Deary, Ian J. [44] ; Degenhardt, Franziska [45, 46] ; Derks, Eske M. [40] ; Direk, Nese [47, 48] ; Dolan, V, Conor ; Dunn, Erin C. [49, 50, 51] ; Eley, Thalia C. [52] ; Escott-Price, Valentina [50] ; Kiadeh, Farnush Farhadi Hassan [53] ; Finucane, Hilary K. [54, 55] ; Forstner, Andreas J. [45, 46, 56, 57] ; Frank, Josef [58] ; Gaspar, Helena A. [52] ; Gill, Michael [59] ; Goes, Fernando S. [60] ; Gordon, Scott D. [40] ; Grove, Jakob [16, 17, 18, 61] ; Hansen, Christine Soholm [17, 30] ; Hansen, Thomas F. [17, 62, 63] ; Herms, Stefan [45, 46, 47] ; Hickie, Ian B. [64] ; Hoffmann, Per [45, 46, 47] ; Homuth, Georg [65] ; Horn, Carsten [66] ; Hottenga, Jouke-Jan [67, 68] ; Hougaard, David M. [17, 30] ; Ising, Marcus [69] ; Jansen, Rick [31, 32] ; Jones, Ian [9] ; Jones, Lisa A. [70] ; Jorgenson, Eric [71] ; Knowles, James A. [72] ; Kohane, Isaac S. [73, 74, 75] ; Kraft, Julia [15] ; Kretzschmar, Warren W. [76] ; Krogh, Jesper [77] ; Kutalik, Zoltan [78, 79] ; Li, Yihan [77] ; Lind, Penelope A. [40] ; MacIntyre, Donald J. [23, 80] ; MacKinnon, Dean F. [60] ; Maier, Robert M. [11] ; Maier, Wolfgang [81] ; Marchini, Jonathan [82] ; Mbarek, Hamdi [67, 68] ; Mcgrath, Patrick [83] ; Mcguffin, Peter [52] ; Medland, Sarah E. [40] ; Mehta, Divya [11, 84] ; Middeldorp, Christel M. [67, 68, 85, 86] ; Mihailov, Evelin [87] ; Milaneschi, Yuri [31, 32] ; Milani, Lili [87] ; Mondimore, Francis M. [60] ; Montgomery, Grant W. [12] ; Mostafavi, Sara [88, 89] ; Mullins, Niamh [52] ; Nauck, Matthias [90, 91] ; Ng, Bernard [89] ; Nivard, Michel G. [67, 68] ; Nyholt, Dale R. [92] ; Oskarsson, Hogni [93] ; Owen, Michael J. [9] ; Painter, Jodie N. [41] ; Pedersen, Carsten Bocker [24, 17, 25] ; Pedersen, Marianne Giortz [24, 17, 25] ; Peterson, Roseann E. [29, 33] ; Pettersson, Erik [35] ; Peyrot, Wouter J. [31, 32] ; Pistis, Giorgio [39] ; Posthuma, Danielle [94, 95] ; Quiroz, Jorge A. [96] ; Qvist, Per [16, 17, 18] ; Rice, John P. [97] ; Riley, Brien P. [29] ; Rivera, Margarita [52, 98] ; Mirza, Saira Saeed [47] ; Schoevers, Robert [99] ; Schulte, Eva C. [100, 101] ; Shen, Ling [71] ; Shyn, I, Stanley ; Sigurdsson, Engilbert [102] ; Sinnamon, Grant C. B. [103] ; Smit, Johannes H. [31, 32] ; Smith, Daniel J. [104] ; Stefansson, Hreinn [105] ; Steinberg, Stacy [105] ; Streit, Fabian [58] ; Strohmaier, Jana [58] ; Tansey, Katherine E. [106] ; Teismann, Henning [107] ; Teumer, Alexander [108] ; Thompson, Wesley [109, 17, 62, 110] ; Thomson, Pippa A. [111] ; Thorgeirsson, Thorgeir E. [106] ; Traylor, Matthew [112] ; Treutlein, Jens [58] ; Trubetskoy, Vassily [15] ; Uitterlinden, Andre G. [113] ; Umbricht, Daniel [114] ; Van der Auwera, Sandra [115] ; van Hemert, Albert M. [116] ; Viktorin, Alexander [35] ; Visscher, Peter M. [11, 12] ; Wang, Yunpeng [17, 62, 110] ; Webb, Bradley T. [33] ; Weinsheimer, Shantel Marie [17, 62] ; Wellmann, Juergen [107] ; Willemsen, Gonneke [67, 68] ; Witt, Stephanie H. [58] ; Wu, Yang [12] ; Xi, Hualin S. [117] ; Yang, Jian [11] ; Zhang, Futao [12] ; Arolt, Volker [118] ; Baune, Bernhard T. [26] ; Berger, Klaus [108] ; Boomsma, I, Dorret ; Cichon, Sven [45, 119, 118, 57] ; Dannlowski, Udo [120] ; de Geus, E. J. C. [121, 122, 123] ; DePaulo, J. Raymond [60] ; Domenici, Enrico [124] ; Domschke, Katharina [125] ; Esko, Tonu [14, 87] ; Grabe, Hans J. [115] ; Hamilton, Steven P. [126] ; Hayward, Caroline [127] ; Heath, Andrew C. [98] ; Kendler, Kenneth S. [29] ; Kloiber, Stefan [128, 129, 66] ; Lewis, Glyn [130] ; Li, Qingqin S. [131] ; Lucae, Susanne [69] ; Madden, Pamela A. F. [98] ; Magnusson, Patrik K. [35] ; Martin, Nicholas G. [40] ; McIntosh, Andrew M. [23, 44, 111] ; Metspalu, Andres [87, 132] ; Mors, Ole [17, 133] ; Mortensen, Preben Bo [24, 17, 18, 25] ; Mueller-Myhsok, Bertram [134, 27, 28] ; Nordentoft, Merete [17, 135] ; Noethen, Markus M. [45, 46] ; O'Donovan, Michael C. [9] ; Paciga, Sara A. [136] ; Pedersen, Nancy L. [35] ; Penninx, Brenda W. J. H. [31, 32] ; Perlis, Roy H. [49, 137] ; Porteous, David J. [111] ; Potash, James B. [138] ; Preisig, Martin [39] ; Rietschel, Marcella [58] ; Schaefer, Catherine [71] ; Schulze, Thomas G. [58, 60, 100, 139, 140] ; Smoller, Jordan W. [49, 14, 51] ; Stefansson, Kari [141, 106] ; Tiemeier, Henning [47, 142, 143] ; Uher, Rudolf [144] ; Voelzke, Henry [108] ; Weissman, Myrna M. [145, 83] ; Werge, Thomas [17, 62, 146] ; Lewis, Cathryn M. [52, 147] ; Levinson, Douglas F. [148] ; Borglum, Anders D. [16, 17, 18] ; Sullivan, Patrick F. [35, 149, 150] ; Meier, Sandra [58] ; Strauss, John [128, 129] ; Xu, Wei [151, 152] ; Vincent, John B. [129] ; Matthews, Keith [153] ; Ferreira, Manuel [154, 155] ; O'Dushlaine, Colm [14] ; Purcell, Shaun [156, 157] ; Raychaudhuri, Soumya [74] ; Ruderfer, Douglas M. [158] ; Sklar, Pamela [156, 159] ; Scott, Laura J. [160, 161] ; Flickinger, Matthew [160, 161] ; Burmeister, Margit [162, 163] ; Li, Jun [160, 161] ; Guan, Weihua [164] ; Absher, Devin [165] ; Thompson, Robert C. [160, 161] ; Meng, Fan Guo [160, 161] ; Schatzberg, Alan F. [148] ; Bunney, William E. [166] ; Barchas, Jack D. [167] ; Watson, Stanley J. [168] ; Myers, Richard M. [165] ; Akil, Huda [162, 163] ; Boehnke, Michael [160, 161] ; Chambert, Kimberly [14] ; Moran, Jennifer [14] ; Scolnick, Edward [14] ; Djurovic, Srdjan [169, 170] ; Melle, Ingrid [171] ; Morken, Gunnar [172, 173] ; Corvin, Aiden [59] ; Anjorin, Adebayo [174] ; Kandaswamy, Radhika [52] ; Lawrence, Jacob [175] ; McLean, Alan W. [23, 111] ; Pickard, Benjamin S. [23, 111] ; Bergen, Sarah E. [35] ; Nimgaonkar, Vishwajit [176] ; Landen, Mikael [35, 177] ; Schalling, Martin [178, 179] ; Osby, Urban [178, 179] ; Backlund, Lena [19] ; Frisen, Louise [178, 179] ; Langstrom, Niklas [177] ; Stahl, Eli [156, 159, 14] ; Dobbyn, Amanda [156, 159] ; Jamain, Stephane [180, 181, 182] ; Etain, Bruno [180, 181, 182] ; Bellivier, Frank [180, 181, 182] ; Leber, Markus [183] ; Maaser, Anna [45, 46] ; Fischer, Sascha B. [184, 118] ; Reinbold, Celine S. [184, 118] ; Kittel-Schneider, Sarah [56] ; Fullerton, Janice M. [185, 186] ; Oruc, Lilijana [185, 186] ; Para, Jose G. [187] ; Mayoral, Fermin [187] ; Rivas, Fabio [187] ; Czerski, Piotr M. [188] ; Kammerer-Ciernioch, Jutta [189] ; Vedder, Helmut [189] ; Borrmann-Hassenbach, Margitta [190] ; Pfennig, Andrea [191] ; Brennan, Paul [192] ; McKay, James D. [192] ; Kogevinas, Manolis [193] ; Schwarz, Markus [189] ; Schofield, Peter R. [185, 186] ; Muehleisen, Thomas W. [184, 119] ; Schumacher, Johannes [45] ; Bauer, Michael [191] ; Wright, Adam [194, 195] ; Mitchell, Philip B. [194, 195] ; Hautzinger, Martin [196] ; Kelsoe, John R. [109] ; Greenwood, Tiffany A. [109] ; Nievergelt, Caroline M. [109] ; Shilling, Paul D. [109] ; Smith, Erin N. [197] ; Bloss, Cinnamon S. [197] ; Edenberg, Howard J. [198, 199] ; Koller, Daniel L. [199] ; Gershon, Elliot S. [200, 201] ; Liu, Chunyu [200, 201] ; Badner, Judith A. [200, 201] ; Scheftner, William A. [202] ; Lawson, William B. [203] ; Nwulia, Evaristus A. [203] ; Hipolito, Maria [203] ; Coryell, William [138] ; Rice, John [204] ; Byerley, William [205] ; McMahon, Francis J. [140] ; Lohoff, Falk W. [206] ; Zandi, Peter P. [207] ; Mahon, Pamela B. [207] ; McInnis, Melvin G. [168] ; Zollner, Sebastian [168] ; Zhang, Peng [168] ; Szelinger, Szabolcs [208] ; St Clair, David [209] ; Caesar, Sian [210] ; Gordon-Smith, Katherine [210] ; Fraser, Christine [9] ; Green, Elaine K. [9] ; Grozeva, Detelina [9] ; Hamshere, Marian L. [9] ; Kirov, George [9] ; Nikolov, Ivan [9] ; Collier, David A. [52] ; Elkin, Amanda [52] ; Williamson, Richard [52] ; Young, Allan H. [211, 212] ; Ferrier, I. Nicol [213] ; Milanova, Vihra [214] ; Alda, Martin [144] ; Cervantes, Pablo [215] ; Cruceanu, Cristiana [27, 215] ; Rouleau, Guy A. [216, 217] ; Turecki, Gustavo [215] ; Paciga, Sara [136] ; Winslow, Ashley R. [218] ; Grigoroiu-Serbanescu, Maria [219] ; Ophoff, Roel [220, 221, 222] ; Adolfsson, Rolf [223] ; Adolfsson, Annelie Nordin [223] ; Del-Favero, Jurgen [224] ; Pato, Carlos [225] ; Biernacka, Joanna M. [226] ; Frye, Mark A. [227] ; Morris, Derek [59, 228] ; Schork, Nicholas J. [229, 197] ; Reif, Andreas [45, 46, 184, 118, 56] ; Lissowska, Jolanta [230, 231] ; Hauser, Joanna [188] ; Szeszenia-Dabrowska, Neonila [232] ; McGhee, Kevin [23, 111] ; Quinn, Emma [233] ; Moskvina, Valentina [9] ; Holmans, Peter A. [234] ; Farmer, Anne [9] ; Kennedy, James L. [128, 129, 235, 236] ; Andreassen, Ole A. [171, 170] ; Mattingsdal, Morten [237] ; Bass, Nicholas J. [130] ; Gurling, Hugh [130] ; McQuillin, Andrew [130] ; Breuer, Rene [58] ; Hultman, Christina [35] ; Lichtenstein, Paul [35] ; Huckins, Laura M. [156, 159] ; Leboyer, Marion [180, 181, 182] ; Lathrop, Mark [238, 239] ; Nurnberger, John [199] ; Steffens, Michael [240] ; Foroud, Tatiana M. [199] ; Berrettini, Wade H. [206] ; Craig, David W. [229] ; Shi, Jianxin [241] ; Bipolar, Major Depressive Disorder
Número total de Autores: 373
Afiliação do(s) autor(es):
Mostrar menos -
[1] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London SE5 8AF - England
[2] Kings Coll London, Maudsley Hosp, London SE5 8AF - England
[3] Kings Coll London, Biomed Res Ctr Mental Hlth, Natl Inst Hlth Res, Inst Psychiat Psychol & Neurosci, London SE5 8AF - England
[4] Univ Fed Sao Paulo UNIFESP EPM, Dept Psychiat, BR-04021001 Sao Paulo - Brazil
[5] Pax Inst Psiquiatria, BR153, Km 505, Villa Sul 5, BR-74911516 Aparecida De Goiania - Brazil
[6] I, Univ Fed Sao Paulo UNIFESP EPM, Dept Morphol & Genet, BR-04021001 Sao Paulo - Brazil
[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London SE5 8AF - England
[8] UCL, Farr Inst Hlth Informat Res, UCL Inst Hlth Informat, London NW1 2DA - England
[9] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Div Psychol Med & Clin Neurosci, Cardiff CF10 3AT, S Glam - Wales
[10] Belangero, Sintia, I, Univ Fed Sao Paulo UNIFESP EPM, Dept Psychiat, BR-04021001 Sao Paulo - Brazil
[11] Univ Queensland, Queensland Brain Inst, Brisbane, Qld - Australia
[12] Univ Queensland, Inst Mol Biosci, Brisbane, Qld - Australia
[13] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 - USA
[14] Brd Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA - USA
[15] Univ Med, Dept Psychiat & Psychotherapy, Charite, Berlin - Germany
[16] Aarhus Univ, Dept Biomed, Aarhus - Denmark
[17] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Aarhus - Denmark
[18] Aarhus Univ, Ctr Integrat Sequencing, iSEQ, Aarhus - Denmark
[19] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm - Sweden
[20] Univ Hosp Wurzburg, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg - Germany
[21] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam - Netherlands
[22] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam - Netherlands
[23] Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian - Scotland
[24] Aarhus Univ, Natl Ctr Register based Res, Aarhus - Denmark
[25] Aarhus Univ, Ctr Integrated Register Based Res, Aarhus - Denmark
[26] Univ Adelaide, Discipline Psychiat, Adelaide, SA - Australia
[27] Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich - Germany
[28] Munich Cluster Syst Neurol SyNergy, Munich - Germany
[29] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA - USA
[30] Statens Serum Inst, Ctr Neonatal Screening, Dept Congenital Disorders, Copenhagen - Denmark
[31] Vrije Univ, Dept Psychiat, Med Ctr, Amsterdam - Netherlands
[32] GGZ inGeest, Amsterdam - Netherlands
[33] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA - USA
[34] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 - USA
[35] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm - Sweden
[36] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus - Denmark
[37] Wellcome Trust Sanger Inst, Human Genet, Cambridge - England
[38] European Bioinformat Inst EMBL EBI, Stat Genom & Syst Genet, Cambridge - England
[39] Univ Hosp Lausanne, Dept Psychiat, Lausanne, Vaud - Switzerland
[40] QIMR Berghofer Med Res Inst, Genet & Computat Biol, Brisbane, Qld - Australia
[41] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld - Australia
[42] Duke Univ, Ctr Genom & Computat Biol, Durham, NC - USA
[43] Duke Univ, Dept Pediat, Div Med Genet, Durham, NC 27706 - USA
[44] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian - Scotland
[45] Univ Bonn, Inst Human Genet, Bonn - Germany
[46] Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn - Germany
[47] Erasmus MC, Epidemiol, Rotterdam, Zuid Holland - Netherlands
[48] Dokuz Eylul Univ, Psychiat, Sch Med, Izmir - Turkey
[49] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 - USA
[50] Cardiff Univ, Neurosci & Mental Hlth, Cardiff, S Glam - Wales
[51] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 - USA
[52] Coleman, Jonathan R., I, Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London SE5 8AF - England
[53] Univ British Columbia, Bioinformat, Vancouver, BC - Canada
[54] MIT, Dept Math, Cambridge, MA 02139 - USA
[55] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[56] Univ Basel, Dept Psychiat UPK, Basel - Switzerland
[57] Univ Basel, Dept Biomed, Human Genom Res Grp, Basel - Switzerland
[58] Heidelberg Univ Mannhe, Med Fac Mannhe, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Baden Wurttemberg - Switzerland
[59] Trinity Coll Dublin, Dept Psychiat, Dublin - Ireland
[60] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD - USA
[61] Aarhus Univ, Bioinformat Res Ctr, Aarhus - Denmark
[62] Mental Hlth Serv Capital Reg Denmark, Inst Biol Psychiat, Mental Hlth Ctr SctHans, Copenhagen - Denmark
[63] Rigshosp, Danish Headache Ctr, Dept Neurol, Glostrup - Denmark
[64] Univ Sydney, Brain & Mind Ctr, Sydney, NSW - Australia
[65] Ernst Moritz Arndt Univ Greifswald, Univ Med & Ernst Moritz Arndt, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, DE - Germany
[66] FHoffmann Roche Ltd, Roche Innovat Ctr Basel, Pharmaceut Sci, Roche Pharmaceut Res & Early Dev, Basel - Switzerland
[67] Dolan, Conor, V, Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam - Netherlands
[68] Dolan, Conor, V, Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam - Netherlands
[69] Max Planck Inst Psychiat, Munich - Germany
[70] Univ Worcester, Dept Psychol Med, Worcester, MA - USA
[71] Kaiser Permanente Northern Calif, Div Res, Oakland, CA - USA
[72] Univ Southern Calif, Psychiat & Behav Sci, Los Angeles, CA - USA
[73] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 - USA
[74] Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 - USA
[75] Boston Childrens Hosp, Informat Program, Boston, MA - USA
[76] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford - England
[77] Univ Copenhagen, Dept Endocrinol, Herlev Univ Hosp, Copenhagen - Denmark
[78] Univ Hosp Lausanne, Inst Social & Prevent Med IUMSP, Lausanne, Vaud - Switzerland
[79] Swiss Inst Bioinformat, Lausanne, Vaud - Switzerland
[80] NHS, Mental Hlth, Glasgow, Lanark - Scotland
[81] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn - Germany
[82] Univ Oxford, Stat, Oxford - England
[83] Columbia Univ, Coll Phys & Surg, Psychiat, New York, NY - USA
[84] Queensland Univ Technol, Sch Psychol & Counseling, Brisbane, Qld - Australia
[85] Childrens Hlth Queensland Hosp & Hlth Serv, Child & Youth Mental Hlth Serv, South Brisbane, Qld - Australia
[86] Univ Queensland, Child Hlth Res Ctr, Brisbane, Qld - Australia
[87] Univ Tartu, Estonian Genome Ctr, Tartu - Estonia
[88] Univ British Columbia, Dept Med Genet, Vancouver, BC - Canada
[89] Univ British Columbia, Dept Stat, Vancouver, BC - Canada
[90] Univ Med Greifswald, Univ Med, DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Mecklenburg Vor - Germany
[91] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Mecklenburg Vor - Germany
[92] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld - Australia
[93] Humus Inc, Reykjavik - Iceland
[94] Vrije Univ, Med Ctr, Clin Genet, Amsterdam - Netherlands
[95] Vrije Univ Amsterdam, Complex Trait Genet, Amsterdam - Netherlands
[96] Solid Biosci, Boston, MA - USA
[97] Washington Univ, Dept Psychiat, St Louis Sch Med, St Louis, MO - USA
[98] Univ Granada, Ctr Biomed Res, Inst Neurosc, Dept Biochem & Mol Biol 2, Granada - Spain
[99] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen - Netherlands
[100] Univ Munich, Med Ctr, Inst Psychiat Phen & Genom, Campus Innenstadt, Munich - Germany
[101] Univ Munich, Dept Psychiat & Psychotherapy, Med Ctr, Campus Innenstadt, Munich - Germany
[102] Univ Iceland, Fac Med, Dept Psychiat, Reykjavik - Iceland
[103] James Cook Univ, Sch Med & Dent, Townsville, Qld - Australia
[104] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark - Scotland
[105] deCODE Genet Amgen, Reykjavik - Iceland
[106] Cardiff Univ, Coll Biomed & Life Sci, Cardiff, S Glam - Wales
[107] Univ Munster, Inst Epidemiol & Social Med, Munster, Nordrhein Westf - Germany
[108] Univ Med Greifswald, Inst Community Med, Greifswald, Mecklenburg Vor - Germany
[109] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 - USA
[110] Oslo Univ Hosp, KG Jebsen Ctr Psychosis Res, Norway Div Mental Hlth & Addict, Oslo - Norway
[111] Univ Edinburgh, Med Genet Sect, IGMM, CGEM, Edinburgh, Midlothian - Scotland
[112] Univ Cambridge, Clin Neurosci, Cambridge - England
[113] Erasmus MC, Internal Med, Rotterdam, Zuid Holland - Netherlands
[114] FHoffmann LaRoche Ltd, Roche Innovat Ctr Basel, Neurosci Ophthalmol & Rare Dis Discovery & Transl, Roche Pharmaceut Res & Early Dev, Basel - Switzerland
[115] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Mecklenburg Vor - Germany
[116] Leiden Univ Med Ctr, Dept Psychiat, Leiden - Netherlands
[117] Pfizer Global Res & Dev, Computat Sci Ctr Emphasis, Cambridge, MA - USA
[118] Univ Basel, Univ Hosp Basel, Inst Med Genet & Pathol, Basel - Switzerland
[119] Res Ctr Juelich, Inst Neurosci & Med INM 1, Julich - Germany
[120] Univ Munster, Dept Psychiat, Munster, Nordrhein Westf - Germany
[121] Boomsma, Dorret, I, Dolan, Conor, V, Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam - Netherlands
[122] Boomsma, Dorret, I, Dolan, Conor, V, Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam - Netherlands
[123] Vrije Univ Med Ctr, Amsterdam Publ Hlth Inst, Amsterdam - Netherlands
[124] Univ Trento, Ctr Integrat Biol, Trento, Trentino Alto A - Italy
[125] Univ Freiburg, Fac Med, Med Ctr, Dept Psychiat & Psychotherapy, Freiburg - Germany
[126] Kaiser Permanente Northern Calif, Psychiat, San Francisco, CA - USA
[127] Univ Edinburgh, Inst Genet & Mol Med, Med Res Council Human Genet Unit, Edinburgh, Midlothian - Scotland
[128] Univ Toronto, Dept Psychiat, Toronto, ON - Canada
[129] Ctr Addict & Mental Hlth, Toronto, ON - Canada
[130] UCL, Div Psychiat, London - England
[131] Janssen Res & Dev LLC, Neurosci Therapeut Area, Titusville, NJ - USA
[132] Univ Tartu, Inst Mol & Cell Biol, Tartu - Estonia
[133] Aarhus Univ Hosp, Psychosis Res Unit, Aarhus - Denmark
[134] Univ Liverpool, Liverpool, Merseyside - England
[135] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Copenhagen - Denmark
[136] Pfizer Global Res & Dev, Human Genet & Computat Biomed, Groton, CT - USA
[137] Harvard Med Sch, Psychiat, Boston, MA 02115 - USA
[138] Univ Iowa, Psychiat, Iowa City, IA - USA
[139] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Niedersachsen - Germany
[140] NIMH, Human Genet Branch, Div Intramural Res Programs, Bethesda, MD 20892 - USA
[141] Univ Iceland, Fac Med, Reykjavik - Iceland
[142] Erasmus MC, Child & Adolescent Psychiat, Rotterdam, Zuid Holland - Netherlands
[143] Erasmus MC, Psychiat, Rotterdam, Zuid Holland - Netherlands
[144] Dalhousie Univ, Dept Psychiat, Halifax, NS - Canada
[145] New York State Psychiat Inst & Hosp, Div Epidemiol, New York, NY 10032 - USA
[146] Univ Copenhagen, Dept Clin Med, Copenhagen - Denmark
[147] Kings Coll London, Dept Med & Mol Genet, London - England
[148] Stanford Univ, Psychiat & Behav Sci, Stanford, CA 94305 - USA
[149] Univ North Carolina Chapel Hill, Dept Genet, Chapel Hill, NC - USA
[150] Univ North Carolina Chapel Hill, Dept Psychiat, Chapel Hill, NC - USA
[151] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON - Canada
[152] Princess Margaret Canc Ctr, Dept Biostat, Toronto, ON - Canada
[153] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian - Scotland
[154] Univ Washington, Med Ctr, Alvord Brain Tumor Ctr, Seattle, WA 98195 - USA
[155] Univ Washington, Med Ctr, Neurol Surg Clin, Seattle, WA 98195 - USA
[156] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 - USA
[157] Brigham & Womens Hosp, Dept Psychiat, 75 Francis St, Boston, MA 02115 - USA
[158] Vanderbilt Univ, Med Ctr, Dept Med Psychiat Biomed Informat, 221 Kirkland Hall, Nashville, TN 37235 - USA
[159] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 - USA
[160] Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 - USA
[161] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 - USA
[162] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 - USA
[163] Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 - USA
[164] Univ Minnesota Syst, Biostat, Minneapolis, MN - USA
[165] HudsonAlpha Inst Biotechnol, Huntsville, AL - USA
[166] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 - USA
[167] Weill Cornell Med Coll, Dept Psychiat, New York, NY - USA
[168] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 - USA
[169] Oslo Univ Hosp, Dept Med Genet, Oslo - Norway
[170] Univ Bergen, KG Jebsen Ctr Psychosis Res, Dept Clin Sci, NORMENT, Bergen - Norway
[171] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo - Norway
[172] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Neurosci, Trondheim - Norway
[173] St Olavs Univ Hosp, Dept Psychiat, Trondheim - Norway
[174] Berkshire Healthcare NHS Fdn Trust, Dept Psychiat, Bracknell, Berks - England
[175] North East London NHS Fdn Trust, Psychiat, Ilford - England
[176] Univ Pittsburgh, Psychiat & Human Genet, Pittsburgh, PA - USA
[177] Univ Gothenburg, Inst Neurosci & Physiol, Gothenburg - Sweden
[178] Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm - Sweden
[179] Karolinska Univ Hosp, Ctr Mol Med, Stockholm - Sweden
[180] INSERM, U955, Psychiat Translat, Creteil - France
[181] Univ Paris Est, Fac Med, Creteil - France
[182] Hop H Mondor A Chenevier, AP HP, Dept Psychiat, Creteil - France
[183] Univ Hosp Cologne, Clin Psychiat & Psychotherapy, Cologne - Germany
[184] Univ Basel, Dept Biomed, Basel - Switzerland
[185] Neurosci Res Australia, Sydney, NSW - Australia
[186] Univ New South Wales, Sch Med Sci, Sydney, NSW - Australia
[187] Univ Reg Hosp, Biomed Inst IBIMA, Mental Hlth Dept, Malaga - Spain
[188] Poznan Univ Med Sci, Dept Psychiat, Lab Psychiat Genet, Poznan - Poland
[189] Psychiat Ctr Nordbaden, Wiesloch - Germany
[190] Kliniken Bezirks Oberbayern, Munich - Germany
[191] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden - Germany
[192] Int Agcy Res Canc, Genet Epidemiol Grp, Lyon - France
[193] Ctr Res Environm Epidemiol CREAL, Barcelona - Spain
[194] Black Dog Inst, Sydney, NSW - Australia
[195] Univ New South Wales, Sch Psychiat, Sydney, NSW - Australia
[196] Univ Tubingen, Inst Psychol, Dept Clin & Dev Psychol, Tubingen - Germany
[197] Scripps Translat Sci Inst & Scripps Hlth, La Jolla, CA - USA
[198] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 - USA
[199] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 - USA
[200] Univ Chicago, Dept Human Genet, Chicago, IL 60637 - USA
[201] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 - USA
[202] Rush Univ, Med Ctr, Chicago, IL 60612 - USA
[203] Howard Univ, Coll Med, Dept Psychiat & Behav Sci, Washington, DC 20059 - USA
[204] Washington Univ, Sch Med, St Louis, MO - USA
[205] Univ Calif San Francisco, Dept Psychiat, Sch Med, San Francisco, CA 94143 - USA
[206] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 - USA
[207] Johns Hopkins Univ & Hosp, Dept Mental Hlth, Baltimore, MD - USA
[208] TGen, Neurogen, Phoenix, AZ - USA
[209] Univ Aberdeen, Inst Med Sci, Foresterhill, Aberdeen - Scotland
[210] Univ Birmingham, Sch Clin & Expt Med, Dept Psychiat, Birmingham, W Midlands - England
[211] Univ Dundee, Ninewells Hosp, Div Neurosci, Dundee - Scotland
[212] Univ Dundee, Med Sch, Dundee - Scotland
[213] Univ British Columbia, Inst Mental Hlth, Vancouver, BC - Canada
[214] Med Univ Sofia, Sofia - Bulgaria
[215] McGill Univ, Dept Psychiat, Mood Disorders Program, Hlth Ctr, Montreal, PQ - Canada
[216] McGill Univ, Fac Med, Dept Neurol & Neurosurg, Montreal, PQ - Canada
[217] Montreal Neurol Hosp & Inst, Montreal, PQ - Canada
[218] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA - USA
[219] Alexandru Obregia Clin Psychiat Hosp, Biometr Psychiat Genet Res Unit, Bucharest - Romania
[220] UMC Utrecht Hersenctr Rudolf Magnus, Psychiat, Utrecht - Netherlands
[221] Univ Calif Los Angeles, Human Genet, Los Angeles, CA - USA
[222] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA - USA
[223] Umea Univ, Med Fac, Dept Clin Sci, Psychiat, Umea - Sweden
[224] Univ Antwerp, VIB Dept Mol Genet, Appl Mol Genom Unit, Antwerp - Belgium
[225] SUNY Downstate Med Ctr, Coll Med, Inst Genom Hlth, Brooklyn, NY 11203 - USA
[226] Mayo Clin, Dept Hlth Sci Res, Rochester, MN - USA
[227] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN - USA
[228] Natl Univ Ireland, Discipline Biochem Neuroimaging & Cognit Genom NI, Galway - Ireland
[229] Univ Southern Calif, Dept Translat Genom, Los Angeles, CA - USA
[230] Inst Oncol, Warsaw - Poland
[231] M Sklodowska Curie Canc Ctr, Canc Epidemiol & Prevent, Warsaw - Poland
[232] Inst Occupat Med, Lodz - Poland
[233] New South Wales Minist Hlth, Sydney, NSW - Australia
[234] Cardiff Univ, Coll Med, Bioinformat & Biostat Unit, Cardiff, S Glam - Wales
[235] Univ Toronto, Inst Med Sci, Toronto, ON - Canada
[236] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON - Canada
[237] Univ Agder, Ctr Coastal Res, Dept Nat Sci, Kristiansand - Norway
[238] McGill Univ, Montreal, PQ - Canada
[239] Genome Quebec Innovat Ctr, Montreal, PQ - Canada
[240] Fed Inst Drugs & Med Devices BfArM, Res Div, Bonn - Germany
[241] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 - USA
Número total de Afiliações: 241
Tipo de documento: Artigo Científico
Fonte: COMMUNICATIONS BIOLOGY; v. 1, 2018.
Citações Web of Science: 3
Resumo

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n similar to 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders. (AU)

Processo FAPESP: 14/50830-2 - Biomarcadores genéticos em pacientes com psicose virgens de tratamento
Beneficiário:Rodrigo Affonseca Bressan
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 10/08968-6 - Investigação de marcadores genéticos e epigenéticos: uma abordagem translacional para o tratamento de esquizofrenia
Beneficiário:Síntia Iole Nogueira Belangero
Modalidade de apoio: Auxílio à Pesquisa - Regular