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Proportion of cancer cases and deaths attributable to lifestyle risk factors in Brazil

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Autor(es):
Machado de Rezende, Leandro Fornias [1, 2, 3] ; Lee, Dong Hoon [1] ; da Costa Louzada, Maria Laura [2, 4] ; Song, Mingyang [5, 6, 1, 7, 8] ; Giovannucci, Edward [5, 6, 1, 9] ; Eluf-Neto, Jose [3]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA - USA
[2] Univ Sao Paulo, Ctr Epidemiol Res Nutr & Hlth, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Av Dr Arnaldo 455, 2nd Floor, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Dept Polit Publ & Saude Colet, Sao Paulo - Brazil
[5] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[6] Harvard Med Sch, Boston, MA 02115 - USA
[7] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 - USA
[8] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 - USA
[9] Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
Número total de Afiliações: 9
Tipo de documento: Artigo Científico
Fonte: CANCER EPIDEMIOLOGY; v. 59, p. 148-157, APR 2019.
Citações Web of Science: 0
Resumo

Background: Lifestyle risk factors (tobacco smoking, alcohol consumption, overweight and obesity, unhealthy diet, and lack of physical activity) have been associated with increased risk of at least 20 types of cancer. We estimated the proportion of cancer cases and deaths that could be potentially avoided by eliminating or reducing lifestyle risk factors in Brazil. Methods: We obtained the distribution of lifestyle risk factors by sex and age groups from recent representative health surveys in Brazil; relative risks from pooled analyses of prospective studies and meta-analyses; and cancer cases and deaths in 2012 from GLOBOCAN. Results: We found that 26.5% (114,497 cases) of all cancer cases and 33.6% (63,371 deaths) of all cancer deaths could be potentially avoided by eliminating lifestyle risk factors in Brazil. Plausible reductions in these exposures based on policy targets and cancer prevention recommendations could have potentially avoided 4.5% (19,731 cases) and 6.1% (11,480 deaths) of all cancer cases and deaths, respectively. Tobacco smoking accounted for most of the preventable cancer cases and deaths, followed by high body mass index and alcohol consumption. Larynx, lung, oropharynx, esophagus and colorectum cancer cases and deaths could be at least halved by eliminating these lifestyle risk factors. Conclusion: Findings from this study may be useful to inform strategies for cancer prevention and control across Brazil. (AU)

Processo FAPESP: 16/21390-0 - Carga do câncer atribuível ao estilo de vida no Brasil
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 14/25614-4 - Inatividade física e câncer: da avaliação da evidência etiológica ao impacto na saúde pública
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Brasil - Doutorado