Homeostatic model assessment of adiponectin (HOMA-Adiponectin) as a surrogate measure of insulin resistance in adolescents: Comparison with the hyperglycaemic clamp and homeostatic model assessment of insulin resistance

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da Silva, Cleliani de Cassia ^{[1, 2, 3]} ; Zambon, Mariana Porto ^{[1, 4, 2]} ; Junqueira Vasques, Ana Carolina ^{[1, 5, 2, 3]} ; Camilo, Daniella Fernandes ^{[1, 2, 3]} ; De Bernardi Rodrigues, Ana Maria ^{[1, 3, 6]} ; de Goes Monteiro Antonio, Maria Angela Reis ^{[1, 4, 2]} ; Damaso, Ana Raimunda ^{[7, 8]} ; Tufik, Sergio ^{[7, 9]} ; de Mello, Marco Tulio ^{[1, 10, 9]} ; da Silveira Campos, Raquel Munhoz ^{[11, 12]} ; Geloneze, Bruno ^{[1, 2, 3]} ; Biill Alves, Arnandra Nichaela ^[1] ; Sitta, Bruna Dyane ^[1] ; Caturani de Araujo, Camila Inajara ^[1] ; Nogueira, Fabiana Lopes ^[1] ; Barreiro-Ribeiro, Francieli ^[1] ; Pareja, Jose Carlos ^[1] ; dos Santos, Leandra Giorgetti ^[1] ; Oliveira, Mariana da Silva ^[1] ; Ferrari, Mariana Pontes ^[1] ; Mello, Mayra ^[1] ; Rodrigues, Patricia Brito ^[1] ; Lara Cassani, Roberta Soares ^[1] ; Rodrigues de Meira, Stela Caroline ^[1] ; Rugolo, Vanessa Cristine ^[1] ; Study, Brazilian Metab Syndrome

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^[1] Univ Estadual Campinas, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Postgrad Program Child & Adolescent Hlth, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Gastroenterol Diag & Res Ctr Gastroctr, Lab Investigat Metab & Diabet Limed, Sao Paulo - Brazil

^[4] Univ Estadual Campinas, Dept Pediat, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Sch Appl Sci, Sao Paulo - Brazil

^[6] Univ Ctr Our Lady Patronage, Sch Hlth & Life Sci, Sao Paulo - Brazil

^[7] Fed Univ Sao Paulo Unifesp, Sao Paulo, SP - Brazil

^[8] Fed Univ Sao Paulo Unifesp, Postgrad Program Nutr, Sao Paulo, SP - Brazil

^[9] Fed Univ Sao Paulo Unifesp, Dept Psychobiol, Sao Paulo, SP - Brazil

^[10] Univ Fed Minas Gerais, Sch Phys Educ Physiotherapy & Occupat Therapy, Belo Horizonte, MG - Brazil

^[11] Fed Univ Sao Carlos UFSCar, Therapeut Resources Lab, Dept Physiotherapy, Sao Paulo - Brazil

^[12] Fed Univ Sao Carlos UFSCar, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 14, n. 3 MAR 25 2019.
• Citações Web of Science: 0

Resumo

Background Studies on adults have reported inverse association between the homeostatic model assessment (HOMA) of adiponectin (HOMA-Adiponectin) and the insulin resistance assessed by the glucose clamp technique. To our knowledge, in the pediatric population this association has not been previously investigated. Objectives To evaluate the association between the HOMA-Adiponectin and the insulin resistance assessed by the glucose clamp technique in adolescents, and to compare the accuracy of HOMA-Adiponectin and HOMA-insulin resistance (HOMA-IR) for identifying insulin resistance. Methods This was a cross-sectional study of 56 adolescents (aged 1018 years). Insulin resistance was assessed using the HOMA-IR, HOMA-Adiponectin and the hyperglycaemic clamp technique. The clamp-derived insulin sensitivity index, HOMA-Adiponectin, and HOMA-IR were log-transformed to get closer to a normal distribution before analysis. Results In the multivariable linear regression analysis controlling for sex and Tanner stage, HOMA-Adiponectin was inversely associated with the clamp-derived insulin sensitivity index (unstandardized coefficient {[}B] = -0.441; P < 0.001). After additional adjustment for waist circumference-to-height ratio, this association remained significant (B = -0.349; P = < 0.001). Similar results were observed when HOMA-IR replaced HOMA-Adiponectin in the model (B = -1.049 and B = -0.968 after additional adjustment for waist circumference-to-height ratio); all P < 0.001. The area under the receiver operating characteristic curve for predicting insulin resistance was 0.712 (P = 0.02) for HOMA-Adiponectin and 0.859 (P < 0.0001) HOMA-IR. Conclusions The HOMA-Adiponectin was independently associated with insulin resistance and exhibited a good discriminatory power for predicting it. However, it did not show superiority over HOMA-IR in the diagnostic accuracy. (AU)

• Processo FAPESP: 13/21476-3 - Validação de métodos substitutivos, laboratoriais e antropométricos, como indicadores de resistência à insulina estudada pelo clamp hiperglicêmico em adolescentes. Brazilian Metabolic Syndrome Study (BRAMS)
• Beneficiário: Cleliani de Cassia da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado