Characterization of PMMA-b-PDMAEMA aggregates in aqueous solutions

Autor(es)

Saraiva, G. K. V. ^[1] ; de Souza, V. V. ^[1] ; Coutinho de Oliveira, L. ^{[1, 2]} ; Noronha, M. L. C. ^{[3, 4]} ; Masini, J. C. ^[5] ; Chaimovich, H. ^[1] ; Salinas, R. K. ^[1] ; Florenzano, F. H. ^[6] ; Cuccovia, I. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Bioquim, Inst Quim, Sao Paulo - Brazil

^[2] INRS Inst Armand Frappier, 531 Blvd Prairies, Laval, PQ H7V 1B7 - Canada

^[3] Univ Fed Alfenas, Inst Ciencias Exatas, Alfenas - Brazil

^[4] Ctr Univ Itajuba, Itajuba - Brazil

^[5] Univ Sao Paulo, Dept Quim Fundamental, Inst Quim, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Dept Engn Mat, Escola Engn Lorena, Lorena, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: COLLOID AND POLYMER SCIENCE; v. 297, n. 4, p. 557-569, APR 2019.
• Citações Web of Science: 0

Resumo

Diblock amphiphilic copolymers form aggregates in some solvents. Such aggregates exhibit different morphologies, depending mainly on the polar/apolar block ratios. Aggregation of copolymers with polar block excess leads to micelle-like aggregates, known as polymeric micelles, which can be used as vehicles for drug and gene delivery, water decontamination, and catalysis. Here, we synthesized by RAFT polymerization three different polymers namely {[}dimethyl 2-(aminoethyl) methacrylate] (PDMAEMA), poly (methyl methacrylate) (PMMA) copolymers, and PDMAEMA-block-PMMA and characterized their aggregates by NMR spectroscopy and pH titrations. We investigated correlations between their chemical structure, aggregation behavior, protonation degree, and chain conformation in the corona. Decreased amine protonation in the copolymers reduced the electrostatic repulsion, and the apparent pK(a) of the amino groups approached that of isolated amine. These effects increased compactness and sizes of the polymers and their aggregates at higher pH as reflected by the increased NMR line widths. (AU)

• Processo FAPESP: 13/08166-5 - Química em interfaces: interações de fármacos, peptídios e enzimas com membranas modelos
• Beneficiário: Iolanda Midea Cuccovia
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/07490-1 - Estudos estruturais acerca do trocador de Na+/Ca2+ e de proteínas do vírus Zika por espectroscopia de Ressonância Magnética Nuclear em solução
• Beneficiário: Roberto Kopke Salinas
• Modalidade de apoio: Auxílio à Pesquisa - Regular