| Autor(es): Mostrar menos - |
Almeida-Oliveira, A. R.
[1, 2]
;
Aquino, Jr., J. C. J.
[1, 2]
;
Abbasi, A.
[3]
;
Santos-Dias, A.
[2]
;
Oliveira, Jr., M. C.
[2]
;
Alberca-Custodio, R. W.
[2]
;
Rigonato-Oliveira, N. C.
[1]
;
Salley-Dias, L. P.
[4]
;
Damaceno-Rodrigues, N. R.
[5]
;
Caldini, E. G.
[5]
;
Arantes-Costa, F. M.
[6]
;
Ligeiro-Oliveira, A. P.
[1]
;
Belvisi, M. G.
[7]
;
Vieira, R. P.
[2, 4, 8, 9]
Número total de Autores: 14
|
| Afiliação do(s) autor(es): | [1] Nove de Julho Univ, Rua Vergueiro 235-249, BR-01504001 Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil
[3] UCLA Med Ctr, Los Angeles Biomed Res Inst Harbor, Dept Med, Div Resp & Crit Care Physiol & Med, Torrance, CA 90502 - USA
[4] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, Campus Itaquera, Rua Carolina Fonseca 235, BR-08230030 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Cell Biol LIM 59, Ave Doutor Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Sch Med, Dept Clin Med, Lab Expt Therapeut LIM 20, Ave Doutor Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[7] Imperial Coll London, Natl Heart & Lung Inst, Airway Dis, Resp Pharmacol Grp, London - England
[8] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Campus Baixada Santista, Av Ana Costa, BR-11060001 Santos, SP - Brazil
[9] Anhembi Morumbi Univ, Sch Med, Ave Deputado Benedito Matarazzo, 4050 Jardim, BR-12230002 Sao Jose Dos Campos, SP - Brazil
Número total de Afiliações: 9
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | EXERCISE IMMUNOLOGY REVIEW; v. 25, p. 98-110, 2019. |
| Citações Web of Science: | 2 |
| Resumo | |
Background: Aerobic training (AT) decreases airway inflammation in asthma, but the underlying cellular and molecular mechanisms are not completely understood. Thus, this study evaluated the participation of SOCS-JAK-STAT signaling in the effects of AT on airway inflammation, remodeling and hyperresponsiveness in a model of allergic airway inflammation. Methods: C57Bl/6 mice were divided into Control (Co), Exercise (Ex), HDM (HDM), and HDM+ Exercise (HDM+ Ex). Dermatophagoides pteronyssinus (100ug/mouse) were administered oro-tracheally on days 0, 7, 14, 21, 28, 35, 42 and 49. AT was performed in a treadmill during 4 weeks in moderate intensity, from day 24 until day 52. Results: AT inhibited HDM-induced total cells (p<0.001), eosinophils (p<0.01), neutrophils (p<0.01) and lymphocytes (p<0.01) in BAL, and eosinophils (p<0.01), neutrophils (p<0.01) and lymphocytes (p<0.01) in peribronchial space. AT also reduced BAL levels of IL-4 (p<0.001), IL-5 (p<0.001), IL-13 (p<0.001), CXCL1 (p<0.01), IL-17 (p<0.01), IL-23 (p<0.05), IL-33 (p<0.05), while increased IL-10 (p<0.05). Airway collagen fibers (p<0.01), elastic fibers p<0.01) and mucin (p<0.01) were also reduced by AT. AT also inhibited HDM-induced airway hyperresponsiveness (AHR) to methacholine 6,25mg/ml (p<0.01), 12,5mg/mL (p<0.01), 25mg/mL (p<0.01) and 50mg/mL (p<0.01). Mechanistically, AT reduced the expression of STAT6 (p<0.05), STAT3 (p<0.001), STAT5 (p<0.01) and JAK2 (p<0.001), similarly by peribronchial leukocytes and by airway epithelial cells. SOCS1 expression (p<0.001) was upregulated in leukocytes and in epithelial cells, SOCS2 (p<0.01) was upregulated in leukocytes and SOCS3 down-regulated in leukocytes (p<0.05) and in epithelial cells (p<0.001). Conclusions: AT reduces asthma phenotype involving SOCS-JAK-STAT signaling. (AU) | |
| Processo FAPESP: | 12/16498-5 - Efeito da terapia com laser de baixa potência (LBP) em modelos experimentais de doenças pulmonares crônicas |
| Beneficiário: | Ana Paula Ligeiro de Oliveira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos |
| Beneficiário: | Rodolfo de Paula Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 14/12755-9 - Efeitos do treinamento físico aeróbio em camundongos obesos asmáticos |
| Beneficiário: | Jefferson Comin Jonco Aquino Junior |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 14/07500-1 - Papel da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelo experimental de asma |
| Beneficiário: | Ana Roberta Almeida Comin |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 12/21519-1 - A via dos leucotrienos contribui para os efeitos antiinflamatórios do treinamento físico aeróbio na asma? |
| Beneficiário: | Ricardo Wesley Alberca Custódio |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |