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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Aerobic Exercise on Molecular Aspects of Asthma: Involvement of SOCS-JAK-STAT

Author(s):
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Almeida-Oliveira, A. R. [1, 2] ; Aquino, Jr., J. C. J. [1, 2] ; Abbasi, A. [3] ; Santos-Dias, A. [2] ; Oliveira, Jr., M. C. [2] ; Alberca-Custodio, R. W. [2] ; Rigonato-Oliveira, N. C. [1] ; Salley-Dias, L. P. [4] ; Damaceno-Rodrigues, N. R. [5] ; Caldini, E. G. [5] ; Arantes-Costa, F. M. [6] ; Ligeiro-Oliveira, A. P. [1] ; Belvisi, M. G. [7] ; Vieira, R. P. [2, 4, 8, 9]
Total Authors: 14
Affiliation:
[1] Nove de Julho Univ, Rua Vergueiro 235-249, BR-01504001 Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil
[3] UCLA Med Ctr, Los Angeles Biomed Res Inst Harbor, Dept Med, Div Resp & Crit Care Physiol & Med, Torrance, CA 90502 - USA
[4] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, Campus Itaquera, Rua Carolina Fonseca 235, BR-08230030 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Cell Biol LIM 59, Ave Doutor Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Sch Med, Dept Clin Med, Lab Expt Therapeut LIM 20, Ave Doutor Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[7] Imperial Coll London, Natl Heart & Lung Inst, Airway Dis, Resp Pharmacol Grp, London - England
[8] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Campus Baixada Santista, Av Ana Costa, BR-11060001 Santos, SP - Brazil
[9] Anhembi Morumbi Univ, Sch Med, Ave Deputado Benedito Matarazzo, 4050 Jardim, BR-12230002 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 9
Document type: Review article
Source: EXERCISE IMMUNOLOGY REVIEW; v. 25, p. 98-110, 2019.
Web of Science Citations: 2
Abstract

Background: Aerobic training (AT) decreases airway inflammation in asthma, but the underlying cellular and molecular mechanisms are not completely understood. Thus, this study evaluated the participation of SOCS-JAK-STAT signaling in the effects of AT on airway inflammation, remodeling and hyperresponsiveness in a model of allergic airway inflammation. Methods: C57Bl/6 mice were divided into Control (Co), Exercise (Ex), HDM (HDM), and HDM+ Exercise (HDM+ Ex). Dermatophagoides pteronyssinus (100ug/mouse) were administered oro-tracheally on days 0, 7, 14, 21, 28, 35, 42 and 49. AT was performed in a treadmill during 4 weeks in moderate intensity, from day 24 until day 52. Results: AT inhibited HDM-induced total cells (p<0.001), eosinophils (p<0.01), neutrophils (p<0.01) and lymphocytes (p<0.01) in BAL, and eosinophils (p<0.01), neutrophils (p<0.01) and lymphocytes (p<0.01) in peribronchial space. AT also reduced BAL levels of IL-4 (p<0.001), IL-5 (p<0.001), IL-13 (p<0.001), CXCL1 (p<0.01), IL-17 (p<0.01), IL-23 (p<0.05), IL-33 (p<0.05), while increased IL-10 (p<0.05). Airway collagen fibers (p<0.01), elastic fibers p<0.01) and mucin (p<0.01) were also reduced by AT. AT also inhibited HDM-induced airway hyperresponsiveness (AHR) to methacholine 6,25mg/ml (p<0.01), 12,5mg/mL (p<0.01), 25mg/mL (p<0.01) and 50mg/mL (p<0.01). Mechanistically, AT reduced the expression of STAT6 (p<0.05), STAT3 (p<0.001), STAT5 (p<0.01) and JAK2 (p<0.001), similarly by peribronchial leukocytes and by airway epithelial cells. SOCS1 expression (p<0.001) was upregulated in leukocytes and in epithelial cells, SOCS2 (p<0.01) was upregulated in leukocytes and SOCS3 down-regulated in leukocytes (p<0.05) and in epithelial cells (p<0.001). Conclusions: AT reduces asthma phenotype involving SOCS-JAK-STAT signaling. (AU)

FAPESP's process: 14/12755-9 - Effects of aerobic physical training in obese asthmatic mice
Grantee:Jefferson Comin Jonco Aquino Junior
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/21519-1 - Is the leukotrienes via contributes to the anti-inflammatory effects of aerobic exercise in asthma?
Grantee:Ricardo Wesley Alberca Custódio
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/16498-5 - Effect of low level laser therapy in experimental models of pulmonary chronic diseases
Grantee:Ana Paula Ligeiro de Oliveira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 14/07500-1 - Role of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic exercise in an experimental model of asthma
Grantee:Ana Roberta Almeida Comin
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support type: Research Grants - Young Investigators Grants