Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals

• Grant number: 12/15165-2
• Support Opportunities: Research Grants - Young Investigators Grants
• Duration: April 01, 2014 - October 31, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rodolfo de Paula Vieira
• Grantee: Rodolfo de Paula Vieira
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
• Associated researchers: Ernesto Cesar Pinto Leal Junior ; Milton de Arruda Martins ; Roberto Stirbulov
• Associated grant(s): 16/08280-0 - Role of bronchial epithelium in the regulation of inflammation in asthma and COPD: new findings and state of art, AV.EXT; 16/50010-0 - Involvement of socs-jak-stat signalling in the effects of aerobic exercise in a model of asthma, AP.R SPRINT; 15/50079-8 - A deep dive in the world of dendritic cells: their role in asthma and in exercise immunology, AP.R SPRINT; 14/07171-8 - multi-user equipment approved in grant 2012/15165-2: flow cytometry Accuri, AP.EMU
• Associated scholarship(s): 19/26116-1 - Role of purinergic signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals, BP.TT; 19/10115-6 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in asthmatic individuals., BP.TT; 19/10990-4 - Effects of aerobic physical training on bronchial inflammation and remodeling in a pre-clinical model of asthma induced by Dermatophagoides pteronyssinus: involvement of purinergic signalling, BP.TT; + associated scholarships 16/24193-0 - Effects of resistance physical training on pulmonary function, mechanics and immune response of elderly with metabolic syndrome, BP.IC; 15/20562-9 - Do the purinergic signaling via bronchial epithelium and leukocytes contributes to anti-inflammatory effects of physical training in a model of asthma?, BP.IC; 15/18821-6 - Effects of aerobic exercise training in pulmonary changes induced by different products of air pollution, BP.IC; 14/23196-0 - The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals., BP.PD; 14/23086-0 - Evaluation of the expression of the proteins suppressor of cytokine signaling (SOCS) in the anti-inflammatory effects of physical training in an experimental model of Asthma, BP.IC; 14/07220-9 - Effects of aerobic physical training on pulmonary and systemic response in a experimental model of Pneumonia induced by Pseudomonas aeruginosa in aged mice, BP.IC; 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite, BP.DR; 14/12755-9 - Effects of aerobic physical training in obese asthmatic mice, BP.MS; 14/07500-1 - Role of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic exercise in an experimental model of asthma, BP.MS - associated scholarships

Abstract

Asthma is a chronic airway inflammatory disease that results in impairment of quality of life. In the last years, several studies have demonstrated that aerobic training (AT) performed properly results in anti-inflammatory effects to the airways, either in experimental models of asthma and to asthmatic individuals. However, although few cellular effects have been investigated (still only in animals' models), the possible extra and intracellular mediators underlying the effects of AT on asthma never were investigated. Thus, the present project aims to evaluate the effects of AT on purinergic signaling and also of SOCS, JAK and STAT proteins signaling on the lungs and lymphatic organs (thymus, spleen and bone marrow) as possible modulators of the anti-inflammatory effects of aerobic training in two experimental models of asthma (by using ovalbumin - OVA and house dust mite - HDM). In addition, this project also aims to evaluate the total and differential cell number in induce sputum, the expression of purinergic receptors and the expression and phosphorilation of SOCS, JAK and STATs in the cells obtained from induced sputum of asthmatic individuals submitted to aerobic training, as well as the levels of inflammatory mediators in the supernatant of induced sputum and also in the condensate of exhaled air. In addition, the antigen presentation by dendritic cells to CD4+ T lymphocytes obtained from peripheral blood of asthmatic patients submitted to rehabilitation will be evaluated. The response of CD4+ T lymphocytes from peripheral blood (proliferation and cytokines production in vitro) will be additionally evaluated. Therefore, this project may present for the first time a real link between basic/experimental with clinical research, concerning the effects of aerobic training for asthma. Then, using two experimental asthma models (OVA and HDM), the animals will be sensitized and challenged and then submitted to aerobic training. 24h after the last session of training and allergen challenge, the animals will be assessed to the inflammatory profile in the bronchoalveolar lavage and in the lung tissue, to the levels of pro-inflammatory cytokines (Th2 cytokines - IL-5 and IL-13 and TNF-alpha) and to the levels of anti-inflammatory cytokines (IL-10, IL-1ra) and also for the expression of sTNFR1 and sTNFR2, as well as for the airway remodeling, pulmonary mechanics and bronchial hyperresponsiveness. (AU)

Scientific publications

(59)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RAMOS, GRACIELLE VIEIRA; DE TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; PINHEIRO-DARDIS, CLARA MARIA; SUEHIRO, CAMILA LIYOKO; DE RUSSO, THIAGO LUIZ; VIEIRA, RODOLFO PAULA; MARTINS, MILTON ARRUDA; SALVINI, TANIA FATIMA; QUAGLIOTTI DURIGAN, JOAO LUIZ. Exercise Prevents Diaphragm Wasting Induced by Cigarette Smoke through Modulation of Antioxidant Genes and Metalloproteinases. BIOMED RESEARCH INTERNATIONAL, 2018. (12/15165-2)

MORAES, GABRIEL DA CUNHA; VITORETTI, LUANA BEATRIZ; DE BRITO, AURILEIA APARECIDA; ALVES, CINTIA ESTEFANO; RIGONATO DE OLIVEIRA, NICOLE CRISTINE; DIAS, ALANA DOS SANTOS; TELES MATOS, YVES SILVA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; FRANCO OLIVEIRA, LUIS VICENTE; DA PALMA, RENATA KELLY; et al. Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. (12/16498-5, 15/13486-4, 12/15165-2, 14/14604-8, 15/23152-6)

SIERRA, ANA PAULA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ALMEIDA, FRANCINE MARIA; BENETTI, MARINO; OLIVEIRA, RODRIGO; FELIX, SORAIA NOGUEIRA; GENARO, ISABELLA SANTOS; SARAIVA ROMANHOLO, BEATRIZ MANGUEIRA; GHORAYEB, NABIL; PEDUTI DAL MOLIN KISS, MARIA AUGUSTA; et al. Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019. (14/14604-8, 12/15165-2, 14/21501-0)

COSTA, IVAN PERES; POLITTI, FABIANO; CAHALIN, LAWRENCE P.; TEIXEIRA DE CARVALHO, ETIENE FARAH; COSTA, DIRCEU; FERRARI CORREA, JOAO CARLOS; VIEIRA, RODOLFO P.; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE ANGELIS, KATIA; STIRBULOV, ROBERTO; et al. Acute Effects Using Light-Emitting Diode Therapy (LEDT) for Muscle Function during Isometric Exercise in Asthma Patients: A Pilot Study. BIOMED RESEARCH INTERNATIONAL, 2019. (12/15165-2)

ANDRADE-SOUSA, ADILSON SANTOS; PEREIRA, PAULO ROGERIO; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; PEREIRA VELOSA, ANA PAULA; TEODORO, WALCY ROSOLIA; et al. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One, v. 11, n. 9, SEP 27 2016. (12/15165-2, 14/14604-8, 14/23196-0, 12/51464-4)

ALMEIDA, FRANCINE MARIA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SOUZA, RENATO APARECIDO; PETRONI, RICARDO COSTA; SOTO, SONIA FATIMA; SORIANO, FRANCISCO GARCIA; CAMILLO DE CARVALHO, PAULO TARSO; ALBERTINI, REGIANE; DAMACENO-RODRIGUES, NILSA REGINA; QUIRINO SANTOS LOPES, FERNANDA DEGOBBI TENORIO; et al. Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury. JOURNAL OF HEART AND LUNG TRANSPLANTATION, v. 35, n. 2, p. 242-250, FEB 2016. (12/15165-2, 14/14604-8, 13/14848-1)

CERVILHA, DANIELA A. B.; ITO, JULIANA T.; LOURENCO, JULIANA D.; OLIVO, CLARICE R.; SARAIVA-ROMANHOLO, BEATRIZ M.; VOLPINI, RILDO A.; OLIVEIRA-JUNIOR, MANOEL C.; MAUAD, THAIS; MARTINS, MILTON A.; TIBERIO, IOLANDA F. L. C.; et al. The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association. SCIENTIFIC REPORTS, v. 9, FEB 13 2019. (12/15165-2)

TOLEDO-ARRUDA, ALESSANDRA C.; VIEIRA, RODOLFO P.; GUARNIER, FLAVIA A.; SUEHIRO, CAMILA L.; CALEMAN-NETO, AGOSTINHO; OLIVO, CLARICE R.; ARANTES, PETRA M. M.; ALMEIDA, FRANCINE M.; LOPES, FERNANDA D. T. Q. S.; RAMOS, ERCY M. C.; et al. Time-course effects of aerobic physical training in the prevention of cigarette smoke-induced COPD. Journal of Applied Physiology, v. 123, n. 3, p. 674-683, SEP 2017. (12/15165-2, 12/09932-0, 09/53904-9)

GONCALVES SILVA, LUCIANA MIATO; ALVES DA SILVA, CAMILA APARECIDA; DA SILVA, ALINE; VIEIRA, RODOLFO PAULA; MESQUITA-FERRARI, RAQUEL AGNELLI; COGO, JOSE CARLOS; ZAMUNER, STELLA REGINA. Photobiomodulation Protects and Promotes Differentiation of C2C12 Myoblast Cells Exposed to Snake Venom. PLoS One, v. 11, n. 4, APR 8 2016. (12/15165-2, 11/04660-0)

SILVA-RENNO, ADRIANO; BALDIVIA, GUILHERME CRISITANINI; OLIVEIRA-JUNIOR, MANOEL C.; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; EL-MAFARJEH, ELIAS; DOLHNIKOFF, MARISA; MAUAD, THAIS; BRITTO, JOSE MARA; NASCIMENTO SALDIVA, PAULO HILARIO; FRANCO OLIVEIRA, LUIS VICENTE; et al. Exercise Performed Concomitantly with Particulate Matter Exposure Inhibits Lung Injury. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 39, n. 2, p. 133-140, FEB 2018. (15/18821-6, 12/15165-2, 14/14604-8)

BARUFI FRANCO, ANA TEREZA; GONCALVES SILVA, LUCIANA MIATO; COSTA, MARCILIA SILVA; ZAMUNER, SILVIA FERNANDA; VIEIRA, RODOLFO PAULA; PEREIRA TEIXEIRA, CATARINA DE FATIMA; ZAMUNER, STELLA REGINA. Effect of photobiomodulation on endothelial cell exposed to Bothrops jararaca venom. Lasers in Medical Science, v. 31, n. 5, p. 1017-1025, JUL 2016. (12/15165-2)

PEREIRA, PAULO ROGERIO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; DAVINO CHIOVATTO, JAIME EDUARDO; MATOS, YVES; GREIFFO, FLAVIA REGINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRUGEMMAN, THAYSE REGINA; DELLE, HUMBERTO; IDZKO, MARCO; et al. Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 7, p. 1276-1284, JUL 2016. (12/15165-2, 14/23196-0, 14/14604-8, 12/51464-4)

ALBERCA-CUSTODIO, RICARDO WESLEY; GREIFFO, FLAVIA REGINA; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUSA, ADILSON SANTOS; GRAUDENZ, GUSTAVO SILVEIRA; GOMES SANTOS, ANGELA BATISTA; DAMACENO-RODRIGUES, NILSA REGINA; CASTRO-FARIA-NETO, HUGO CAIRE; ARANTES-COSTA, FERNANDA MAGALHAES; et al. Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway. FRONTIERS IN IMMUNOLOGY, v. 7, JUN 14 2016. (12/15165-2, 14/23196-0, 13/23763-0, 12/23305-9, 14/14604-8, 12/21519-1, 14/09292-7)

MACKENZIE, BREANNE; ANDRADE-SOUSA, ADILSON SANTOS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; SILVA-RENNO, ADRIANO; SANTOS-DIAS, ALANA; CICKO, SANJA; GRIMM, MELANIE; MUELLER, TOBIAS; et al. Dendritic Cells Are Involved in the Effects of Exercise in a Model of Asthma. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 8, p. 1459-1467, AUG 2016. (12/15165-2, 15/50079-8)

RIGONATO-OLIVEIRA, NICOLE CRISTINE; MACKENZIE, BREANNE; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DELLE, HUMBERTO; COSTA-GUIMARAES, TAMARA; DAMACENO-RODRIGUES, NILSA REGINA; DULLEY, LARISSA HILARIO; et al. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. EXERCISE IMMUNOLOGY REVIEW, v. 24, p. 48-56, 2018. (12/25435-7, 12/15165-2, 14/23196-0, 12/24880-7)

EL-MAFARJEH, ELIAS; MARTINS, GISELE HENRIQUE CARDOSO; PROBST, JESSICA JORGE; SANTOS-DIAS, ALANA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE BARROS, MARCELO PAES; DE OLIVEIRA, LUIS VICENTE FRANCO; DE ANDRADE, LEANDRO DAMAS; DA PALMA, RENATA KELLY; MORAES-FERREIRA, RENILSON; et al. Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, OCT 17 2020. (19/14115-0, 17/06032-2, 14/14604-8, 16/04845-3, 12/51464-4, 15/20562-9, 12/15165-2, 19/11008-9)

MASSARO, HELDER; ZAMBELLI, LIGIA F. A.; DE BRITTO, AURILEIA A.; VIEIRA, RODOLFO P.; LIGEIRO-DE-OLIVEIRA, ANA P.; ANDIA, DENISE C.; OLIVEIRA, MARCELO T.; LIMA, ADRIANO F.. Solvent and HEMA Increase Adhesive Toxicity and Cytokine Release from Dental Pulp Cells. MATERIALS, v. 12, n. 17, SEP 2019. (13/02928-0, 12/15165-2)

DE GENARO, ISABELLA SANTOS; DE ALMEIDA, FRANCINE MARIA; QUIRINO DOS SANTOS LOPES, FERNANDA DEGOBBI TENORIO; HIZUME KUNZLER, DEBORAH DE CAMARGO; BUSOLETTO TRIPODE, BRUNA GABRYELA; KURDEJAK, ADRIANA; NAKAMURA CORDEIRO, BRUNA; PANDOLPHO, RENATA; MACCHIONE, MARIANGELA; BRUGGEMANN, THAYSE REGINA; et al. Low-dose chlorine exposure impairs lung function, inflammation and oxidative stress in mice. Life Sciences, v. 267, FEB 15 2021. (14/26829-4, 18/02537-5, 12/15165-2)

PAIXAO, VITORIA; ALMEIDA, EWIN B.; AMARAL, JONATAS B.; ROSEIRA, TAMARIS; MONTEIRO, FERNANDA R.; FOSTER, ROBERTA; SPERANDIO, ADRIANE; ROSSI, MARCELO; AMIRATO, GISLENE R.; SANTOS, CARLOS A. F.; et al. Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination. VACCINES, v. 9, n. 2, FEB 2021. (19/13188-4, 19/13094-0, 12/15165-2, 19/14115-0)

RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; MORAES-FERREIRA, RENILSON; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; LACERDA BACHI, ANDRE LUIS; GABRIELA-PEREIRA, GIOVANA; FREITAS, SIMONE DE OLIVEIRA; ARAUJO-ROSA, AMANDA CRISTINA; FRANCO OLIVEIRA, LUIS VICENTE; FRISON, CLAUDIO RICARDO; et al. Pulmonary function changes in older adults with and without metabolic syndrome. SCIENTIFIC REPORTS, v. 11, n. 1, AUG 30 2021. (12/15165-2, 19/05739-0, 19/11008-9)

BATISTA DOS SANTOS, JULIANA DE MELO; FOSTER, ROBERTA; JONCKHEERE, ANNE-CHARLOTTE; ROSSI, MARCELO; LUNA JUNIOR, LUIZ ANTONIO; KATEKARU, CATHERINE MACHADO; DE SA, MATHEUS CAVALCANTE; PAGANI, LUCAS GUIMARAES; DE ALMEIDA, FRANCINE MARIA; AMARAL, JONATAS DO BUSSADOR; et al. Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 16, n. 22, NOV 2019. (12/15165-2, 17/00307-0, 16/04845-3)

DE CAMARGO, ANDERSON ALVES; SILVA DE CASTRO, REJANE AGNELO; VIEIRA, RODOLFO P.; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE ARAUJO, AMANDA APARECIDA; DE ANGELIS, KATIA; RACHED, SAMIA ZAHI; ATHANAZIO, RODRIGO ABENSUR; STELMACH, RAFAEL; DAL CORSO, SIMONE. Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features. Clinics, v. 76, 2021. (14/14604-8, 10/09732-6, 12/15165-2, 14/01902-0)

DOS SANTOS, JULIANA DE MELO BATISTA; DO AMARAL, JONATAS BUSSADOR; FRANCA, CAROLINA NUNES; MONTEIRO, FERNANDA RODRIGUES; ALVARES-SARAIVA, ANUSKA MARCELINO; KALIL, SANDRA; DURIGON, EDISON LUIZ; OLIVEIRA, DANIELLE BRUNA LEAL; RODRIGUES, SILVIA SANCHES; HELLER, DEBORA; et al. Distinct Immunological Profiles Help in the Maintenance of Salivary Secretory IgA Production in Mild Symptoms COVID-19 Patients. FRONTIERS IN IMMUNOLOGY, v. 13, p. 13-pg., 2022-05-24. (20/06409-1, 12/15165-2, 19/14115-0, 16/20045-7)

RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; OLIVEIRA, CARLOS ROCHA; DA SILVA OLIMPIO, FABIANA REGINA; AIMBIRE, FLAVIO; MATEUS-SILVA, JOSE ROBERTO; CHALUPPE, FELIPE AUGUSTO; VIEIRA, RODOLFO P.. Hydrolyzed Collagen Induces an Anti-Inflammatory Response That Induces Proliferation of Skin Fibroblast and Keratinocytes. NUTRIENTS, v. 14, n. 23, p. 13-pg., 2022-12-01. (19/05739-0, 12/15165-2)

DE GENARO, ISABELLA SANTOS; DE ALMEIDA, FRANCINE MARIA; HIZUME-KUNZLER, DEBORAH CAMARGO; MORIYA, HENRIQUE TAKACHI; SILVA, RONALDO APARECIDO; GONCALVES CRUZ, JOAO CARLOS; LOPES, RENAN BOEIRA; RIGHETTI, RENATO FRAGA; VIEIRA, RODOLFO DE PAULA; SAIKI, MITIKO; et al. Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice. SCIENTIFIC REPORTS, v. 8, AUG 22 2018. (12/15165-2, 09/53904-9)

RAMOS, GRACIELLE VIEIRA; DE SOUSA NETO, IVO VIEIRA; TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; MARQUETI, RITA DE CASSIA; VIEIRA, RODOLFO P.; MARTINS, MILTON A.; SALVINI, TANIA; DURIGAN, JOAO LUIZ QUAGLIOTI. Moderate Treadmill Training Induces Limited Effects on Quadriceps Muscle Hypertrophy in Mice Exposed to Cigarette Smoke Involving Metalloproteinase 2. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v. 17, p. 33-42, 2022. (12/15165-2)

GARCIA, MONIQUE; SANTOS-DIAS, ALANA; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUZA, ADILSON SANTOS; FERREIRA, SERGIO CESAR; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; ALMEIDA, FRANCINE MARIA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LIGEIRO OLIVEIRA, ANA PAULA; et al. Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 x 7 receptor. European Journal of Immunology, v. 49, n. 6, p. 928-939, JUN 2019. (14/12755-9, 12/16498-5, 14/14604-8, 12/15165-2)

ALMEIDA, EWIN B.; SILVA, KARINA P. H.; PAIXAO, VITORIA; DO AMARAL, JONATAS B.; ROSSI, MARCELO; XAVIER-NAVARRO, ROBERTA A.; BARROS, KARINA V.; SILVEIRA, VERA L. F.; VIEIRA, RODOLFO P.; OLIVEIRA, LUIS V. F.; et al. A Mixture of Polyunsaturated Fatty Acids omega-3 and omega-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 15, AUG 2019. (12/15165-2, 16/04845-3)

DE PAULIS, MILENA; OLIVEIRA, DANIELLE BRUNA LEAL; VIEIRA, RODOLFO P.; PINTO, ISABELLA COUTINHO; MACHADO, RAFAEL RAHAL GUARAGNA; CAVALCANTI, MARIANA PAUFERRO; SOARES, CAMILA PEREIRA; DE ARAUJO, ANANDA MEDEIROS PEREIRA; ARAUJO, DANIELLE BASTOS; BACHI, ANDRE LUIS LACERDA; et al. Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report. PEDIATRIC INFECTIOUS DISEASE JOURNAL, v. 39, n. 10, p. 4-pg., 2020-10-01. (16/04845-3, 18/23680-0, 20/06409-1, 12/15165-2, 17/24769-2)

PIRES, RENIER S.; BRAGA, PEDRO G. S.; SANTOS, JULIANA M. B.; AMARAL, JONATAS B.; AMIRATO, GISLENE R.; TRETTEL, CAIO S.; DOS SANTOS, CARLOS A. F.; VAISBERG, MAURO; NALI, LUIS H. S.; VIEIRA, RODOLFO P.; et al. L-Glutamine supplementation enhances glutathione peroxidase and paraoxonase-1 activities in HDL of exercising older individuals. Experimental Gerontology, v. 156, DEC 2021. (19/14115-0, 12/15165-2)

ALMEIDA-OLIVEIRA, A. R.; AQUINO, JR., J. C. J.; ABBASI, A.; SANTOS-DIAS, A.; OLIVEIRA, JR., M. C.; ALBERCA-CUSTODIO, R. W.; RIGONATO-OLIVEIRA, N. C.; SALLEY-DIAS, L. P.; DAMACENO-RODRIGUES, N. R.; CALDINI, E. G.; et al. Effects of Aerobic Exercise on Molecular Aspects of Asthma: Involvement of SOCS-JAK-STAT. EXERCISE IMMUNOLOGY REVIEW, v. 25, p. 98-110, 2019. (12/16498-5, 12/15165-2, 14/12755-9, 14/07500-1, 12/21519-1)

ABRAHIN, ODILON; CORTINHAS-ALVES, ERIK ARTUR; VIEIRA, RODOLFO PAULA; GUERREIRO, JOAO FARIAS. Elite athletes have longer telomeres than sedentary subjects: A meta-analysis. Experimental Gerontology, v. 119, p. 138-145, MAY 2019. (12/15165-2)

MORAES-FERREIRA, RENILSON; BRANDAO-RANGEL, MAYSA ALVES RODRIGUES; GIBSON-ALVES, THIAGO GONCALVES; SILVA-REIS, ANAMEI; SOUZA-PALMEIRA, VICTOR HUGO; AQUINO-SANTOS, HELIDA CRISTINA; FRISON, CLAUDIO RICARDO; OLIVEIRA, LUIS VICENTE FRANCO; ALBERTINI, REGIANE; VIEIRA, RODOLFO P.. Physical Training Reduces Chronic Airway Inflammation and Mediators of Remodeling in Asthma. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2022, p. 13-pg., 2022-10-20. (20/03994-0, 19/11008-9, 12/15165-2, 19/11244-4, 19/05739-0)

COSTA, IVAN PERES; POLITTI, FABIANO; CAHALIN, LAWRENCE P.; TEIXEIRA DE CARVALHO, ETIENE FARAH; COSTA, DIRCEU; FERRARI CORREA, JOAO CARLOS; VIEIRA, RODOLFO P.; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE ANGELIS, KATIA; STIRBULOV, ROBERTO; et al. Acute Effects Using Light-Emitting Diode Therapy (LEDT) for Muscle Function during Isometric Exercise in Asthma Patients: A Pilot Study. BIOMED RESEARCH INTERNATIONAL, v. 2019, p. 10-pg., 2019-01-01. (12/15165-2)

SIERRA, ANA PAULA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ALMEIDA, FRANCINE MARIA; BENETTI, MARINO; OLIVEIRA, RODRIGO; FELIX, SORAIA NOGUEIRA; GENARO, ISABELLA SANTOS; SARAIVA ROMANHOLO, BEATRIZ MANGUEIRA; GHORAYEB, NABIL; PEDUTI DAL MOLIN KISS, MARIA AUGUSTA; et al. Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2019, p. 6-pg., 2019-01-01. (14/14604-8, 12/15165-2, 14/21501-0)

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