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Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals

Grant number: 12/15165-2
Support type:Research Grants - Young Investigators Grants
Duration: April 01, 2014 - October 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Rodolfo de Paula Vieira
Grantee:Rodolfo de Paula Vieira
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Assoc. researchers:Ernesto Cesar Pinto Leal Junior ; Milton de Arruda Martins ; Roberto Stirbulov
Associated grant(s):16/08280-0 - Role of bronchial epithelium in the regulation of inflammation in asthma and COPD: new findings and state of art, AV.EXT
16/50010-0 - Involvement of socs-jak-stat signalling in the effects of aerobic exercise in a model of asthma, AP.R SPRINT
15/50079-8 - A deep dive in the world of dendritic cells: their role in asthma and in exercise immunology, AP.R SPRINT
14/07171-8 - multi-user equipment approved in grant 2012/15165-2: flow cytometry Accuri, AP.EMU
Associated scholarship(s):19/26116-1 - Role of purinergic signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals, BP.TT
19/10115-6 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in asthmatic individuals., BP.TT
19/10990-4 - Effects of aerobic physical training on bronchial inflammation and remodeling in a pre-clinical model of asthma induced by Dermatophagoides pteronyssinus: involvement of purinergic signalling, BP.TT
+ associated scholarships 16/24193-0 - Effects of resistance physical training on pulmonary function, mechanics and immune response of elderly with metabolic syndrome, BP.IC
15/20562-9 - Do the purinergic signaling via bronchial epithelium and leukocytes contributes to anti-inflammatory effects of physical training in a model of asthma?, BP.IC
15/18821-6 - Effects of aerobic exercise training in pulmonary changes induced by different products of air pollution, BP.IC
14/23196-0 - The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals., BP.PD
14/23086-0 - Evaluation of the expression of the proteins suppressor of cytokine signaling (SOCS) in the anti-inflammatory effects of physical training in an experimental model of Asthma, BP.IC
14/07220-9 - Effects of Aerobic Physical Training on Pulmonary and Systemic Response in a Experimental Model of Pneumonia Induced by Pseudomonas aeruginosa in Aged Mice, BP.IC
14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite, BP.DR
14/12755-9 - Effects of aerobic physical training in obese asthmatic mice, BP.MS
14/07500-1 - Role of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic exercise in an experimental model of asthma, BP.MS - associated scholarships

Abstract

Asthma is a chronic airway inflammatory disease that results in impairment of quality of life. In the last years, several studies have demonstrated that aerobic training (AT) performed properly results in anti-inflammatory effects to the airways, either in experimental models of asthma and to asthmatic individuals. However, although few cellular effects have been investigated (still only in animals' models), the possible extra and intracellular mediators underlying the effects of AT on asthma never were investigated. Thus, the present project aims to evaluate the effects of AT on purinergic signaling and also of SOCS, JAK and STAT proteins signaling on the lungs and lymphatic organs (thymus, spleen and bone marrow) as possible modulators of the anti-inflammatory effects of aerobic training in two experimental models of asthma (by using ovalbumin - OVA and house dust mite - HDM). In addition, this project also aims to evaluate the total and differential cell number in induce sputum, the expression of purinergic receptors and the expression and phosphorilation of SOCS, JAK and STATs in the cells obtained from induced sputum of asthmatic individuals submitted to aerobic training, as well as the levels of inflammatory mediators in the supernatant of induced sputum and also in the condensate of exhaled air. In addition, the antigen presentation by dendritic cells to CD4+ T lymphocytes obtained from peripheral blood of asthmatic patients submitted to rehabilitation will be evaluated. The response of CD4+ T lymphocytes from peripheral blood (proliferation and cytokines production in vitro) will be additionally evaluated. Therefore, this project may present for the first time a real link between basic/experimental with clinical research, concerning the effects of aerobic training for asthma. Then, using two experimental asthma models (OVA and HDM), the animals will be sensitized and challenged and then submitted to aerobic training. 24h after the last session of training and allergen challenge, the animals will be assessed to the inflammatory profile in the bronchoalveolar lavage and in the lung tissue, to the levels of pro-inflammatory cytokines (Th2 cytokines - IL-5 and IL-13 and TNF-alpha) and to the levels of anti-inflammatory cytokines (IL-10, IL-1ra) and also for the expression of sTNFR1 and sTNFR2, as well as for the airway remodeling, pulmonary mechanics and bronchial hyperresponsiveness. (AU)

Scientific publications (37)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, FERNANDA R.; ROSEIRA, TAMARIS; AMARAL, JONATAS B.; PAIXAO, VITORIA; ALMEIDA, EWIN B.; FOSTER, ROBERTA; SPERANDIO, ADRIANE; ROSSI, MARCELO; AMIRATO, GISLENE R.; APOSTOLICO, JULIANA S.; SANTOS, CARLOS A. F.; FELISMINO, EDUARDO S.; LEAL, FABYANO B.; THOMAZELLI, LUCIANO M.; DURIGON, EDISON L.; OLIVEIRA, DANIELLE B. L.; VIEIRA, RODOLFO P.; SANTOS, JULIANA M. B.; BACHI, ANDRE L. L. Combined Exercise Training and l-Glutamine Supplementation Enhances Both Humoral and Cellular Immune Responses after Influenza Virus Vaccination in Elderly Subjects. VACCINES, v. 8, n. 4 DEC 2020. Web of Science Citations: 0.
EL-MAFARJEH, ELIAS; MARTINS, GISELE HENRIQUE CARDOSO; PROBST, JESSICA JORGE; SANTOS-DIAS, ALANA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE BARROS, MARCELO PAES; DE OLIVEIRA, LUIS VICENTE FRANCO; DE ANDRADE, LEANDRO DAMAS; DA PALMA, RENATA KELLY; MORAES-FERREIRA, RENILSON; DE CAMARGO HIZUME-KUNZLER, DEBORAH; BACHI, ANDRE LUIS LACERDA; VIEIRA, RODOLFO P. Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, OCT 17 2020. Web of Science Citations: 0.
ALMEIDA, FRANCINE M.; BATTOCHIO, ANGELA S.; NAPOLI, JOAO P.; ALVES, KATIUSA A.; BALBIN, GRACE S.; OLIVEIRA-JUNIOR, MANOEL; MORIYA, HENRIQUE T.; PEGO-FERNANDES, PAULO M.; VIEIRA, RODOLFO P.; PAZETTI, ROGERIO. Creatine Supply Attenuates Ischemia-Reperfusion Injury in Lung Transplantation in Rats. NUTRIENTS, v. 12, n. 9 SEP 2020. Web of Science Citations: 0.
CIOLAC, EMMANUEL GOMES; RODRIGUES DA SILVA, JOSE MESSIAS; VIEIRA, RODOLFO PAULA. Physical Exercise as an Immunomodulator of Chronic Diseases in Aging. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 17, n. 6, p. 662-672, JUN 2020. Web of Science Citations: 0.
BATISTA DOS SANTOS, JULIANA DE MELO; LACERDA BACHI, ANDRE LUIS; LUNA JUNIOR, LUIZ ANTONIO; FOSTER, ROBERTA; RENNO SIERRA, ANA PAULA; BENETTI, MARINO; ARAUJO, JOSE ROBERTO; GHORAYEB, NABIL; DAL'MOLIM KISS, MARIA AUGUSTA PEDUTI; VIEIRA, RODOLFO P.; BULLENS, DOMINIQUE M. A.; VAISBERG, MAURO. The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 17, n. 8 APR 2020. Web of Science Citations: 0.
ALMEIDA, EWIN B.; SANTOS, JULIANA M. B.; PAIXAO, VITORIA; AMARAL, JONATAS B.; FOSTER, ROBERTA; SPERANDIO, ADRIANE; ROSEIRA, TAMARIS; ROSSI, MARCELO; CORDEIRO, TELMA G.; MONTEIRO, FERNANDA R.; AMIRATO, GISLENE R.; SANTOS, CARLOS A. F.; VIEIRA, RODOLFO P.; VAISBERG, MAURO; BARROS, MARCELO; BACHI, ANDRE L. L. L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2020, JAN 22 2020. Web of Science Citations: 0.
PAGANI, LUCAS G.; SANTOS, JULIANA M. B.; FOSTER, ROBERTA; ROSSI, MARCELO; LUNA JUNIOR, LUIZ A.; KATEKARU, CATHERINE M.; DE SA, MATHEUS C.; JONCKHEERE, ANNE-CHARLOTTE; ALMEIDA, FRANCINE M.; AMARAL, JONATAS B.; VIEIRA, RODOLFO P.; BULLENS, DOMINIQUE M. A.; BACHI, ANDRE L. L.; VAISBERG, MAURO. The Effect of Particulate Matter Exposure on the Inflammatory Airway Response of Street Runners and Sedentary People. ATMOSPHERE, v. 11, n. 1 JAN 2020. Web of Science Citations: 0.
BATISTA DOS SANTOS, JULIANA DE MELO; FOSTER, ROBERTA; JONCKHEERE, ANNE-CHARLOTTE; ROSSI, MARCELO; LUNA JUNIOR, LUIZ ANTONIO; KATEKARU, CATHERINE MACHADO; DE SA, MATHEUS CAVALCANTE; PAGANI, LUCAS GUIMARAES; DE ALMEIDA, FRANCINE MARIA; AMARAL, JONATAS DO BUSSADOR; VIEIRA, RODOLFO DE PAULA; LACERDA BACHI, ANDRE LUIS; BULLENS, DOMINIQUE MAGDALENA A.; VAISBERG, MAURO. Outdoor Endurance Training with Air Pollutant Exposure Versus Sedentary Lifestyle: A Comparison of Airway Immune Responses. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 16, n. 22 NOV 2019. Web of Science Citations: 0.
DAVINO-CHIOVATTO, JAIME EDUARDO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; SANTOS-DIAS, ALANA; ALMEIDA-OLIVEIRA, ANA ROBERTA; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; BRITO, AURILEIA APARECIDA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; DAMACENO-RODRIGUES, NILSA REGINA; LIGEIRO OLIVEIRA, ANA PAULA; SILVA, ALESSANDRO PEREIRA; CONSOLIM-COLOMBO, FERNANDA MARCIANO; AIMBIRE, FLAVIO; CASTRO-FARIA-NETO, HUGO CAIRE; VIEIRA, RODOLFO PAULA. Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation. ARCHIVOS DE BRONCONEUMOLOGIA, v. 55, n. 11, p. 573-580, NOV 2019. Web of Science Citations: 1.
MASSARO, HELDER; ZAMBELLI, LIGIA F. A.; DE BRITTO, AURILEIA A.; VIEIRA, RODOLFO P.; LIGEIRO-DE-OLIVEIRA, ANA P.; ANDIA, DENISE C.; OLIVEIRA, MARCELO T.; LIMA, ADRIANO F. Solvent and HEMA Increase Adhesive Toxicity and Cytokine Release from Dental Pulp Cells. MATERIALS, v. 12, n. 17 SEP 2019. Web of Science Citations: 1.
BACHI, ANDRE L. L.; BARROS, MARCELO P.; VIEIRA, RODOLFO P.; ROCHA, GISLENE A.; DE ANDRADE, PAULA B. M.; VICTORINO, ANGELICA B.; RAMOS, LUIZ R.; GRAVINA, CLAUDIA F.; LOPES, JOSE D.; VAISBERG, MAURO; MARANHAO, RAUL C. Combined Exercise Training Performed by Elderly Women Reduces Redox Indexes and Proinflammatory Cytokines Related to Atherogenesis. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2019, AUG 5 2019. Web of Science Citations: 1.
ALMEIDA, EWIN B.; SILVA, KARINA P. H.; PAIXAO, VITORIA; DO AMARAL, JONATAS B.; ROSSI, MARCELO; XAVIER-NAVARRO, ROBERTA A.; BARROS, KARINA V.; SILVEIRA, VERA L. F.; VIEIRA, RODOLFO P.; OLIVEIRA, LUIS V. F.; PEREZ, ELIZABETH C.; JASIULIONIS, MIRIAM G.; BACHI, ANDRE L. L. A Mixture of Polyunsaturated Fatty Acids omega-3 and omega-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 15 AUG 2019. Web of Science Citations: 0.
VAISBERG, MAURO; PAIXAO, VITORIA; ALMEIDA, EWIN B.; SANTOS, JULIANA M. B.; FOSTER, ROBERTA; ROSSI, MARCELO; PITHON-CURI, TANIA C.; GORJAO, RENATA; MOMESSO, CESAR M.; ANDRADE, MARILIA S.; ARAUJO, JOSE R.; GARCIA, MAURICIO C.; COHEN, MOISES; PEREZ, ELIZABETH C.; SANTOS-DIAS, ALANA; VIEIRA, RODOLFO P.; BACHI, ANDRE L. L. Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners. NUTRIENTS, v. 11, n. 7 JUL 2019. Web of Science Citations: 2.
GARCIA, MONIQUE; SANTOS-DIAS, ALANA; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUZA, ADILSON SANTOS; FERREIRA, SERGIO CESAR; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; ALMEIDA, FRANCINE MARIA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LIGEIRO OLIVEIRA, ANA PAULA; BAGGIO SAVIO, LUIZ EDUARDO; COUTINHO-SILVA, ROBSON; MUELLER, TOBIAS; IDZKO, MARCO; SIEPMANN, TIMO; VIEIRA, RODOLFO PAULA. Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 x 7 receptor. European Journal of Immunology, v. 49, n. 6, p. 928-939, JUN 2019. Web of Science Citations: 1.
ABRAHIN, ODILON; CORTINHAS-ALVES, ERIK ARTUR; VIEIRA, RODOLFO PAULA; GUERREIRO, JOAO FARIAS. Elite athletes have longer telomeres than sedentary subjects: A meta-analysis. Experimental Gerontology, v. 119, p. 138-145, MAY 2019. Web of Science Citations: 0.
CERVILHA, DANIELA A. B.; ITO, JULIANA T.; LOURENCO, JULIANA D.; OLIVO, CLARICE R.; SARAIVA-ROMANHOLO, BEATRIZ M.; VOLPINI, RILDO A.; OLIVEIRA-JUNIOR, MANOEL C.; MAUAD, THAIS; MARTINS, MILTON A.; TIBERIO, IOLANDA F. L. C.; VIEIRA, RODOLFO P.; LOPES, FERNANDA D. T. Q. S. The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association. SCIENTIFIC REPORTS, v. 9, FEB 13 2019. Web of Science Citations: 1.
ALMEIDA-OLIVEIRA, A. R.; AQUINO, JR., J. C. J.; ABBASI, A.; SANTOS-DIAS, A.; OLIVEIRA, JR., M. C.; ALBERCA-CUSTODIO, R. W.; RIGONATO-OLIVEIRA, N. C.; SALLEY-DIAS, L. P.; DAMACENO-RODRIGUES, N. R.; CALDINI, E. G.; ARANTES-COSTA, F. M.; LIGEIRO-OLIVEIRA, A. P.; BELVISI, M. G.; VIEIRA, R. P. Effects of Aerobic Exercise on Molecular Aspects of Asthma: Involvement of SOCS-JAK-STAT. EXERCISE IMMUNOLOGY REVIEW, v. 25, p. 98-110, 2019. Web of Science Citations: 2.
COSTA, IVAN PERES; POLITTI, FABIANO; CAHALIN, LAWRENCE P.; TEIXEIRA DE CARVALHO, ETIENE FARAH; COSTA, DIRCEU; FERRARI CORREA, JOAO CARLOS; VIEIRA, RODOLFO P.; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; DE ANGELIS, KATIA; STIRBULOV, ROBERTO; DAL CORSO, SIMONE; DE CARVALHO, PAULO DE TARSO; PARIZOTTO, NIVALDO ANTONIO; ARENA, ROSS; SAMPAIO, LUCIANAMARIA MALOSA. Acute Effects Using Light-Emitting Diode Therapy (LEDT) for Muscle Function during Isometric Exercise in Asthma Patients: A Pilot Study. BIOMED RESEARCH INTERNATIONAL, 2019. Web of Science Citations: 0.
SIERRA, ANA PAULA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ALMEIDA, FRANCINE MARIA; BENETTI, MARINO; OLIVEIRA, RODRIGO; FELIX, SORAIA NOGUEIRA; GENARO, ISABELLA SANTOS; SARAIVA ROMANHOLO, BEATRIZ MANGUEIRA; GHORAYEB, NABIL; PEDUTI DAL MOLIN KISS, MARIA AUGUSTA; CURY-BOAVENTURA, MARIA FERNANDA; PESQUERO, JOAO BOSCO; VIEIRA, RODOLFO PAULA. Impairment on Cardiopulmonary Function after Marathon: Role of Exhaled Nitric Oxide. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2019. Web of Science Citations: 1.
DE GENARO, ISABELLA SANTOS; DE ALMEIDA, FRANCINE MARIA; HIZUME-KUNZLER, DEBORAH CAMARGO; MORIYA, HENRIQUE TAKACHI; SILVA, RONALDO APARECIDO; GONCALVES CRUZ, JOAO CARLOS; LOPES, RENAN BOEIRA; RIGHETTI, RENATO FRAGA; VIEIRA, RODOLFO DE PAULA; SAIKI, MITIKO; MARTINS, MILTON ARRUDA; LOPES CALVO TIBERIO, IOLANDA DE FATIMA; ARANTES-COSTA, FERNANDA MAGALHAES; SARAIVA-ROMANHOLO, BEATRIZ MANGUEIRA. Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice. SCIENTIFIC REPORTS, v. 8, AUG 22 2018. Web of Science Citations: 2.
JONCO AQUINO-JUNIOR, JEFFERSON COMIN; MACKENZIE, BREANNE; ALMEIDA-OLIVEIRA, ANA ROBERTA; MARTINS, ANA CAROLINA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; BRITTO, AURILEA APARECIDA; ARANTES-COSTA, FERNANDA MAGALHAES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; LIGEIRO DE OLIVEIRA, ANA PAULA; GUADAGNINI, DIOZE; LEIRIA, LUIZ OSORIO; RICARDO, DJALMA RABELO; ABDALLA SAAD, MARIO JOSE; VIEIRA, RODOLFO PAULA. Aerobic exercise inhibits obesity-induced respiratory phenotype. CYTOKINE, v. 104, p. 46-52, APR 2018. Web of Science Citations: 1.
SILVA-RENNO, ADRIANO; BALDIVIA, GUILHERME CRISITANINI; OLIVEIRA-JUNIOR, MANOEL C.; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; EL-MAFARJEH, ELIAS; DOLHNIKOFF, MARISA; MAUAD, THAIS; BRITTO, JOSE MARA; NASCIMENTO SALDIVA, PAULO HILARIO; FRANCO OLIVEIRA, LUIS VICENTE; LIGEIRO-OLIVEIRA, ANA P.; GRAUDENZ, GUSTAVO SILVEIRA; VIEIRA, RODOLFO PAULA. Exercise Performed Concomitantly with Particulate Matter Exposure Inhibits Lung Injury. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 39, n. 2, p. 133-140, FEB 2018. Web of Science Citations: 2.
DURIGON, THOMAS STRAVINSKAS; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; DE ANGELIS, KATIA; MALFITANO, CHRISTIANO; DA PALMA, RENATA KELLY; GUERRA, JULIANA MORENO; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; DE ALMEIDA, FRANCINE MARIA; AQUINO-SANTOS, HELIDA CRISTINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LEAL DE OLIVEIRA, DANIELLE BRUNA; AIMBIRE, FLAVIO; LIGEIRO DE OLIVEIRA, ANA PAULA; FRANCO DE OLIVEIRA, LUIZ VICENTE; DURIGON, EDISON LUIZ; HIEMSTRA, PIETER S.; VIEIRA, RODOLFO P. Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. JOURNAL OF INNATE IMMUNITY, v. 10, n. 4, p. 279-290, 2018. Web of Science Citations: 2.
MORAES, GABRIEL DA CUNHA; VITORETTI, LUANA BEATRIZ; DE BRITO, AURILEIA APARECIDA; ALVES, CINTIA ESTEFANO; RIGONATO DE OLIVEIRA, NICOLE CRISTINE; DIAS, ALANA DOS SANTOS; TELES MATOS, YVES SILVA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; FRANCO OLIVEIRA, LUIS VICENTE; DA PALMA, RENATA KELLY; CANDEO, LARISSA CARBONERA; LINO-DOS-SANTOS-FRANCO, ADRIANA; RATTO TEMPESTINE HORLIANA, ANNA CAROLINA; GIMENES, JOAO ANTONIO JUNIOR; AIMBIRE, FLAVIO; VIEIRA, RODOLFO PAULA; LIGEIRO-DE-OLIVEIRA, ANA PAULA. Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. Web of Science Citations: 2.
RAMOS, GRACIELLE VIEIRA; DE TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; PINHEIRO-DARDIS, CLARA MARIA; SUEHIRO, CAMILA LIYOKO; DE RUSSO, THIAGO LUIZ; VIEIRA, RODOLFO PAULA; MARTINS, MILTON ARRUDA; SALVINI, TANIA FATIMA; QUAGLIOTTI DURIGAN, JOAO LUIZ. Exercise Prevents Diaphragm Wasting Induced by Cigarette Smoke through Modulation of Antioxidant Genes and Metalloproteinases. BIOMED RESEARCH INTERNATIONAL, 2018. Web of Science Citations: 2.
RIGONATO-OLIVEIRA, NICOLE CRISTINE; MACKENZIE, BREANNE; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DELLE, HUMBERTO; COSTA-GUIMARAES, TAMARA; DAMACENO-RODRIGUES, NILSA REGINA; DULLEY, LARISSA HILARIO; BENETTI, MARCELA ANHESINI; MALFITANO, CHRISTIANE; DE ANGELIS, KATIA; ALBERTINI, REGIANE; LIGEIRO OLIVEIRA, ANA PAULA; ABBASI, ASGHAR; NORTHOFF, HINNAK; VIEIRA, RODOLFO PAULA. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. EXERCISE IMMUNOLOGY REVIEW, v. 24, p. 48-56, 2018. Web of Science Citations: 5.
TOLEDO-ARRUDA, ALESSANDRA C.; VIEIRA, RODOLFO P.; GUARNIER, FLAVIA A.; SUEHIRO, CAMILA L.; CALEMAN-NETO, AGOSTINHO; OLIVO, CLARICE R.; ARANTES, PETRA M. M.; ALMEIDA, FRANCINE M.; LOPES, FERNANDA D. T. Q. S.; RAMOS, ERCY M. C.; CECCHINI, RUBENS; LIN, CHIN JIA; MARTINS, MILTON ARRUDA. Time-course effects of aerobic physical training in the prevention of cigarette smoke-induced COPD. Journal of Applied Physiology, v. 123, n. 3, p. 674-683, SEP 2017. Web of Science Citations: 7.
RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ABBASI, ASGHAR; SILVA-RENNO, ADRIANO; DE BRITO, AURILEIA APARECIDA; LIGEIRO DE OLIVEIRA, ANA PAULA; TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; BELVISI, MARIA GABRIELA; VIEIRA, RODOLFO PAULA. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017. Web of Science Citations: 4.
ANDRADE-SOUSA, ADILSON SANTOS; PEREIRA, PAULO ROGERIO; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; PEREIRA VELOSA, ANA PAULA; TEODORO, WALCY ROSOLIA; LIGEIRO DE OLIVEIRA, ANA PAULA; DOLHNIKOFF, MARISA; EICKELBERG, OLIVER; VIEIRA, RODOLFO PAULA. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One, v. 11, n. 9 SEP 27 2016. Web of Science Citations: 5.
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