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Effects of resistance physical training on pulmonary function, mechanics and immune response of elderly with metabolic syndrome

Grant number: 16/24193-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rodolfo de Paula Vieira
Grantee:Giovana Gabriela Pereira
Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
Associated research grant:12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals, AP.JP


Population aging is a global phenomenon and is related to the increased prevalence and incidence of chronic non-communicable diseases such as type 2 diabetes, obesity, hypertension and dyslipidemias. The presence of three or more of these dysfunctions in the same individual is called metabolic syndrome, greatly decreasing a life expectancy. In addition, the literature demonstrates that characteristic factors of the metabolic syndrome, such as diabetes, hypertension, obesity, and dyslipidemia may also adversely affect lung function. The physical training has been associated with the reduction of several factors of the metabolic syndrome. The protocol of low to moderate intensity aerobic training of mild to moderate intensity is the most studied and therefore also the most recommended for individuals with metabolic syndrome. However, more recent evidence shows that resistance training may also be of great value for the treatment of metabolic syndrome, but the number of studies is still small and many questions remain open. Thus, since resistance training is highly indicated for the elderly and some evidence demonstrates beneficial effects on some features of the metabolic syndrome, the present study will evaluate the effects of moderate intensity resistance training, performed 3x per week on health and quality of life, as well as on lung function and mechanics and on pulmonary immune response of the elderly with metabolic syndrome. (AU)

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