Effect of a pulmonary rehabilitation in the clinical control and health related quality of life in obese asthmatics

• Grant number: 12/16134-3
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): January 01, 2013
• Effective date (End): March 31, 2016
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Celso Ricardo Fernandes de Carvalho
• Grantee: Patricia Duarte Freitas
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Asthma is a chronic inflammatory disease of the airways, and obesity is a metabolic syndrome. Both have shown a high prevalence in the last decades and became a serious global health problem. The association between asthma and obesity appears to result in a " unique phenotype", characterized by a disease in which patients have many symptoms, more severe and variable response to drug therapies. Studies suggest that weight reduction by surgery in asthmatics obese reduces symptoms of asthma. On the other hand, despite many studies suggest that exercise has anti-inflammatory and immunoregulatory, which may be important in asthma control, these effects in asthmatics obese are poorly understood. Objective: This study will assess the effect of weight loss with or not to exercise training in clinical management and health factors related to quality of life in obese asthmatics. Methods: 56 asthmatic adults (BMI 35 to 39.9 kg/m2) of both genders will be randomly divided into 2 groups: control (nutrition and psychological programs, stretching and breathing exercises) and trained (nutrition and psychological program and aerobic and resistance exercise). The program will be held in 32 sessions, twice per week, during 90 minutes. Everybody will be evaluated before and after the intervention on the clinical management, health factors related to quality of life, levels of pulmonary and systemic inflammation, levels of anxiety and depression, sleep disorders, lung function, physical capacity, body composition and anthropometric indexes. Sample size calculation was presented for this study. The comparison between the initial and final data will be made by ANOVA with two factors, if any difference will be used to test post-hoc Bonferroni test. The significance level is set to 5% (p <0.05) for all tests.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FREITAS, PATRICIA DUARTE; SILVA, ALINE GRANDI; FERREIRA, PALMIRA GABRIELE; DA SILVA, ANALUCI; SALGE, JOAO MARCOS; CARVALHO-PINTO, REGINA MARIA; CUKIER, ALBERTO; BRITO, CLAUDIA M.; MANCINI, MARCIO C.; CARVALHO, CELSO R. F. Exercise Improves Physical Activity and Comorbidities in Obese Adults with Asthma. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 7, p. 1367-1376, JUL 2018. Web of Science Citations: 6.

FREITAS, PATRICIA D.; FERREIRA, PALMIRA G.; SILVA, ALINE G.; STELMACH, RAFAEL; CARVALHO-PINTO, REGINA M.; FERNANDES, FREDERICO L. A.; MANCINI, MARCIA C.; SATO, MARIA N.; MARTINS, MILTON A.; CARVALHO, CELSO R. F. The Role of Exercise in a Weight-Loss Program on Clinical Control in Obese Adults with Asthma A Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine, v. 195, n. 1, p. 32-42, JAN 1 2017. Web of Science Citations: 59.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FREITAS, Patricia Duarte. Effect of exercise training in a weight loss program on asthma clinical and health related quality of life in obese adults with asthma. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina São Paulo.