Asthma is a chronic inflammatory disease of the airways, and obesity is a metabolic syndrome. Both have shown a high prevalence in the last decades and became a serious global health problem. The association between asthma and obesity appears to result in a " unique phenotype", characterized by a disease in which patients have many symptoms, more severe and variable response to drug therapies. Studies suggest that weight reduction by surgery in asthmatics obese reduces symptoms of asthma. On the other hand, despite many studies suggest that exercise has anti-inflammatory and immunoregulatory, which may be important in asthma control, these effects in asthmatics obese are poorly understood. Objective: This study will assess the effect of weight loss with or not to exercise training in clinical management and health factors related to quality of life in obese asthmatics. Methods: 56 asthmatic adults (BMI 35 to 39.9 kg/m2) of both genders will be randomly divided into 2 groups: control (nutrition and psychological programs, stretching and breathing exercises) and trained (nutrition and psychological program and aerobic and resistance exercise). The program will be held in 32 sessions, twice per week, during 90 minutes. Everybody will be evaluated before and after the intervention on the clinical management, health factors related to quality of life, levels of pulmonary and systemic inflammation, levels of anxiety and depression, sleep disorders, lung function, physical capacity, body composition and anthropometric indexes. Sample size calculation was presented for this study. The comparison between the initial and final data will be made by ANOVA with two factors, if any difference will be used to test post-hoc Bonferroni test. The significance level is set to 5% (p <0.05) for all tests.
News published in Agência FAPESP Newsletter about the scholarship: