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Effects of combined physical training on the pulmonary mechanics and function and on the pulmonary and systemic immune response of obese women

Grant number: 19/11244-4
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2019
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rodolfo de Paula Vieira
Grantee:Anamei Silva Reis
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

The prevalence of obesity has grown rapidly in virtually the entire world. Numerous comorbidities due to obesity have been studied, which decrease life expectancy as well as quality of life. Among the less studied comorbidities are lung and immunologic alterations, which are significantly affected by obesity. On the other hand, the regular practice of physical activity is indicated as one of the main components of a weight loss program and also to reduce the appearance and help in the control of comorbidities due to obesity. In addition, the regular practice of physical activity is also known as an important tool capable of improving and keeping the immune system in good condition, in addition to being essential and bring numerous benefits to the lungs, including improvement of the pattern and respiratory function. Thus, the present study aims to evaluate the effects of combined physical training (aerobic + resistance) on pulmonary function and mechanical changes and on the pulmonary and systemic immune changes of sedentary obese women. For this, 120 women will be recruited, 60 obese (obesity grade 1 or 2) and 60 eutrophic, who will be submitted to the following evaluations and re-evaluations and to combined physical training (aerobic + resistance), 3x/week, 1 hour/session, for 6 months]: complete pulmonary function (spirometry), pulmonary mechanics (oscillometry), bronchial hyperresponsiveness to physical exercise, condensed air (measurement of pro and anti-fibrotic mediators and pro and anti-inflammatory mediators), induced sputum (pulmonary inflammation), complete blood count (systemic inflammation), complete lipidogram, pro and anti-fibrotic and pro-and anti-inflammatory mediators in the serum, inspiratory and expiratory muscle strength (PIMax and PEMax), exhaled nitric oxide levels, electrocardiogram, blood pressure, oxygen saturation in rest, body composition by multi-frequency octopolar bioimpedance and anthropometric evaluation, as well as the questionnaires to evaluate the quality of life (SF-36), respiratory symptoms (Mahler's Dyspnea Scale) and physical activity level (IPAQ). (AU)