| Author(s): Show less - |
Rigonato-Oliveira, Nicole Cristine
[1]
;
MacKenzie, BreAnne
[2]
;
Lacerda Bachi, Andre Luis
[2]
;
Oliveira-Junior, Manoel Carneiro
[2]
;
Santos-Dias, Alana
[2]
;
Rodrigues Brandao-Rangel, Maysa Alves
[2, 3]
;
Delle, Humberto
[1]
;
Costa-Guimaraes, Tamara
[4, 2]
;
Damaceno-Rodrigues, Nilsa Regina
[5]
;
Dulley, Larissa Hilario
[2]
;
Benetti, Marcela Anhesini
[2]
;
Malfitano, Christiane
[6]
;
de Angelis, Katia
[7]
;
Albertini, Regiane
[3]
;
Ligeiro Oliveira, Ana Paula
[1]
;
Abbasi, Asghar
[8]
;
Northoff, Hinnak
[9]
;
Vieira, Rodolfo Paula
[4, 2, 3]
Total Authors: 18
|
| Affiliation: | [1] Nove Julho Univ, Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP - Brazil
[4] Univ Brasil, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Pathol LIM 59, Sao Paulo, SP - Brazil
[6] Univ Fed Lavras UFLA, Sci Dept Hlth, Lavras, MG - Brazil
[7] Fed Univ Sao Paulo UNIFESP, Campus Sao Paulo, Sao Paulo, SP - Brazil
[8] Harbor UCLA Med Ctr, Div Resp & Crit Care Physiol & Med, Los Angeles Biomed Res Inst, Torrance, CA 90509 - USA
[9] Univ Tubingen, Inst Clin & Expt Transfus Med IKET, Tubingen - Germany
Total Affiliations: 9
|
| Document type: | Review article |
| Source: | EXERCISE IMMUNOLOGY REVIEW; v. 24, p. 48-56, 2018. |
| Web of Science Citations: | 5 |
| Abstract | |
Acute respiratory distress syndrome (ARDS) is defined as hypoxemic respiratory failure with intense pulmonary inflammation, involving hyperactivation of endothelial cells and neutrophils. Given the anti-inflammatory effects of aerobic exercise (AE), this study investigated whether AE performed daily for 5 weeks would inhibit extra-pulmonary LPS-induced ARDS. C57Bl/6 mice were distributed into Control, Exercise, LPS and Exercise+ LPS groups. AE was performed on a treadmill for 5x/week for four weeks before LPS administration. 24hours after the final AE physical test, animals received 100ug of LPS intra-peritoneally. In addition, whole blood cell culture, neutrophils and human endothelial cells were pre-incubated with IL-10, an anti-inflammatory cytokine induced by exercise. AE reduced total protein levels (p<0.01) and neutrophil accumulation in bronchoalveolar lavage (BAL) (p<0.01) and lung parenchyma (p<0.01). AE reduced BAL inflammatory cytokines IL-1 beta, IL-6 and GM-CSF (p<0.001), CXCL1/KC, IL-17, TNF-alpha and IGF-1 (p<0.01). Systemically, AE reduced IL-1 beta, IL-6 and IFN-gamma (p<0.001), CXCL1/KC (p<0.01) and TNF-alpha (p<0.05). AE increased IL-10 levels in serum (p<0.001) and BAL (p<0.001). Furthermore, AE increased superoxide dismutase SOD (p<0.01) and decreased superoxide anion accumulation in the lungs (p<0.01). Lastly, pre-incubation with IL-10 significantly reduced LPS-induced activation of whole blood cells, neutrophils and HUVECs, as observed by reduced production of IL-1 beta, IL-6, IL-8 and TNF-alpha. Our data suggest that AE inhibited LPS-induced lung inflammation by attenuating inflammatory cytokines and oxidative stress markers in mice and human cell culture via enhanced IL-10 production. (AU) | |
| FAPESP's process: | 12/25435-7 - Effects of aerobic physical training on leukocytes activation in an experimental model of intra and extra-pulmonary acute lung injury |
| Grantee: | Larissa Hilario Dulley |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 14/23196-0 - The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals. |
| Grantee: | Breanne Mackenzie |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 12/24880-7 - Effects of aerobic physical training on bronchial epithelial cells and alveolar epithelial cells in a model of pulmonary and extra-pulmonary acute lung injury |
| Grantee: | Marcela Anhesini Benetti |
| Support type: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support type: | Research Grants - Young Investigators Grants |