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The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals.

Grant number: 14/23196-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2015
Effective date (End): April 30, 2017
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Rodolfo de Paula Vieira
Grantee:Breanne Mackenzie
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Associated research grant:12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals, AP.JP

Abstract

Asthma is a chronic airway inflammatory disease that results in impairment of quality of life of asthmatic individuals. In the last years, several studies have shown that the aerobic physical training (APT) performed at proper intensity and volume present anti-inflammatory effects to the airways, both in experimental models of asthma as to asthmatic individuals. However, although few cellular effects of have been investigated (only in experimental studies), the study of possible mediators (intra and extracellular) involved in the effects of APT in asthma was not yet investigated. Thus, the present project will evaluate the number of total and differential cells in the induced sputum, the expression of purinergic receptors and of proteins SOCS, JAKs and STATs in the cells of induced sputum of asthmatic patients submitted to APT, the levels of inflammatory mediators in the supernatants of induced sputum and/or in the breath condensate. Furthermore, the antigen presentation by dendritic cells to CD4+ T lymphocytes from the peripheral blood of asthmatic patients submitted to APT also will be evaluated. In addition, the proliferation and in vitro cytokines production by CD4+ T lymphocytes from the peripheral blood of asthmatic patients submitted to APT will be evaluated.

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAVINO-CHIOVATTO, JAIME EDUARDO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; SANTOS-DIAS, ALANA; ALMEIDA-OLIVEIRA, ANA ROBERTA; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; BRITO, AURILEIA APARECIDA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; DAMACENO-RODRIGUES, NILSA REGINA; LIGEIRO OLIVEIRA, ANA PAULA; SILVA, ALESSANDRO PEREIRA; CONSOLIM-COLOMBO, FERNANDA MARCIANO; AIMBIRE, FLAVIO; CASTRO-FARIA-NETO, HUGO CAIRE; VIEIRA, RODOLFO PAULA. Montelukast, Leukotriene Inhibitor, Reduces LPS-Induced Acute Lung Inflammation and Human Neutrophil Activation. ARCHIVOS DE BRONCONEUMOLOGIA, v. 55, n. 11, p. 573-580, NOV 2019. Web of Science Citations: 1.
DURIGON, THOMAS STRAVINSKAS; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; DE ANGELIS, KATIA; MALFITANO, CHRISTIANO; DA PALMA, RENATA KELLY; GUERRA, JULIANA MORENO; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; DE ALMEIDA, FRANCINE MARIA; AQUINO-SANTOS, HELIDA CRISTINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LEAL DE OLIVEIRA, DANIELLE BRUNA; AIMBIRE, FLAVIO; LIGEIRO DE OLIVEIRA, ANA PAULA; FRANCO DE OLIVEIRA, LUIZ VICENTE; DURIGON, EDISON LUIZ; HIEMSTRA, PIETER S.; VIEIRA, RODOLFO P. Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. JOURNAL OF INNATE IMMUNITY, v. 10, n. 4, p. 279-290, 2018. Web of Science Citations: 2.
RIGONATO-OLIVEIRA, NICOLE CRISTINE; MACKENZIE, BREANNE; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DELLE, HUMBERTO; COSTA-GUIMARAES, TAMARA; DAMACENO-RODRIGUES, NILSA REGINA; DULLEY, LARISSA HILARIO; BENETTI, MARCELA ANHESINI; MALFITANO, CHRISTIANE; DE ANGELIS, KATIA; ALBERTINI, REGIANE; LIGEIRO OLIVEIRA, ANA PAULA; ABBASI, ASGHAR; NORTHOFF, HINNAK; VIEIRA, RODOLFO PAULA. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. EXERCISE IMMUNOLOGY REVIEW, v. 24, p. 48-56, 2018. Web of Science Citations: 5.
ANDRADE-SOUSA, ADILSON SANTOS; PEREIRA, PAULO ROGERIO; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ASSUMPCAO-NETO, ERASMO; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; PEREIRA VELOSA, ANA PAULA; TEODORO, WALCY ROSOLIA; LIGEIRO DE OLIVEIRA, ANA PAULA; DOLHNIKOFF, MARISA; EICKELBERG, OLIVER; VIEIRA, RODOLFO PAULA. Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One, v. 11, n. 9 SEP 27 2016. Web of Science Citations: 5.
PEREIRA, PAULO ROGERIO; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; MACKENZIE, BREANNE; DAVINO CHIOVATTO, JAIME EDUARDO; MATOS, YVES; GREIFFO, FLAVIA REGINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRUGEMMAN, THAYSE REGINA; DELLE, HUMBERTO; IDZKO, MARCO; ALBERTINI, REGIANE; LIGEIRO OLIVEIRA, ANA PAULA; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; FERNANDEZ, ISIS ENSIL; CASTRO-FARIA-NETO, HUGO CAIRE; DOLHNIKOFF, MARISA; EICKELBERG, OLIVER; VIEIRA, RODOLFO PAULA. Exercise Reduces Lung Fibrosis Involving Serotonin/Akt Signaling. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 7, p. 1276-1284, JUL 2016. Web of Science Citations: 11.
ALBERCA-CUSTODIO, RICARDO WESLEY; GREIFFO, FLAVIA REGINA; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUSA, ADILSON SANTOS; GRAUDENZ, GUSTAVO SILVEIRA; GOMES SANTOS, ANGELA BATISTA; DAMACENO-RODRIGUES, NILSA REGINA; CASTRO-FARIA-NETO, HUGO CAIRE; ARANTES-COSTA, FERNANDA MAGALHAES; MARTINS, MILTON DE ARRUDA; ABBASI, ASGHAR; LIN, CHIN JIA; IDZKO, MARCO; LIGEIRO OLIVEIRA, ANA PAULA; NORTHOFF, HINNAK; VIEIRA, RODOLFO PAULA. Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway. FRONTIERS IN IMMUNOLOGY, v. 7, JUN 14 2016. Web of Science Citations: 9.

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