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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells

Author(s):
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Rigonato-Oliveira, Nicole Cristine [1] ; MacKenzie, BreAnne [2] ; Lacerda Bachi, Andre Luis [2] ; Oliveira-Junior, Manoel Carneiro [2] ; Santos-Dias, Alana [2] ; Rodrigues Brandao-Rangel, Maysa Alves [2, 3] ; Delle, Humberto [1] ; Costa-Guimaraes, Tamara [4, 2] ; Damaceno-Rodrigues, Nilsa Regina [5] ; Dulley, Larissa Hilario [2] ; Benetti, Marcela Anhesini [2] ; Malfitano, Christiane [6] ; de Angelis, Katia [7] ; Albertini, Regiane [3] ; Ligeiro Oliveira, Ana Paula [1] ; Abbasi, Asghar [8] ; Northoff, Hinnak [9] ; Vieira, Rodolfo Paula [4, 2, 3]
Total Authors: 18
Affiliation:
[1] Nove Julho Univ, Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP - Brazil
[4] Univ Brasil, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Pathol LIM 59, Sao Paulo, SP - Brazil
[6] Univ Fed Lavras UFLA, Sci Dept Hlth, Lavras, MG - Brazil
[7] Fed Univ Sao Paulo UNIFESP, Campus Sao Paulo, Sao Paulo, SP - Brazil
[8] Harbor UCLA Med Ctr, Div Resp & Crit Care Physiol & Med, Los Angeles Biomed Res Inst, Torrance, CA 90509 - USA
[9] Univ Tubingen, Inst Clin & Expt Transfus Med IKET, Tubingen - Germany
Total Affiliations: 9
Document type: Review article
Source: EXERCISE IMMUNOLOGY REVIEW; v. 24, p. 48-56, 2018.
Web of Science Citations: 5
Abstract

Acute respiratory distress syndrome (ARDS) is defined as hypoxemic respiratory failure with intense pulmonary inflammation, involving hyperactivation of endothelial cells and neutrophils. Given the anti-inflammatory effects of aerobic exercise (AE), this study investigated whether AE performed daily for 5 weeks would inhibit extra-pulmonary LPS-induced ARDS. C57Bl/6 mice were distributed into Control, Exercise, LPS and Exercise+ LPS groups. AE was performed on a treadmill for 5x/week for four weeks before LPS administration. 24hours after the final AE physical test, animals received 100ug of LPS intra-peritoneally. In addition, whole blood cell culture, neutrophils and human endothelial cells were pre-incubated with IL-10, an anti-inflammatory cytokine induced by exercise. AE reduced total protein levels (p<0.01) and neutrophil accumulation in bronchoalveolar lavage (BAL) (p<0.01) and lung parenchyma (p<0.01). AE reduced BAL inflammatory cytokines IL-1 beta, IL-6 and GM-CSF (p<0.001), CXCL1/KC, IL-17, TNF-alpha and IGF-1 (p<0.01). Systemically, AE reduced IL-1 beta, IL-6 and IFN-gamma (p<0.001), CXCL1/KC (p<0.01) and TNF-alpha (p<0.05). AE increased IL-10 levels in serum (p<0.001) and BAL (p<0.001). Furthermore, AE increased superoxide dismutase SOD (p<0.01) and decreased superoxide anion accumulation in the lungs (p<0.01). Lastly, pre-incubation with IL-10 significantly reduced LPS-induced activation of whole blood cells, neutrophils and HUVECs, as observed by reduced production of IL-1 beta, IL-6, IL-8 and TNF-alpha. Our data suggest that AE inhibited LPS-induced lung inflammation by attenuating inflammatory cytokines and oxidative stress markers in mice and human cell culture via enhanced IL-10 production. (AU)

FAPESP's process: 12/25435-7 - Effects of aerobic physical training on leukocytes activation in an experimental model of intra and extra-pulmonary acute lung injury
Grantee:Larissa Hilario Dulley
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/24880-7 - Effects of Aerobic Physical Training on Bronchial Epithelial Cells and Alveolar Epithelial Cells in a Model of Pulmonary and Extra-pulmonary Acute Lung Injury
Grantee:Marcela Anhesini Benetti
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/23196-0 - The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals.
Grantee:Breanne Mackenzie
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support type: Research Grants - Young Investigators Grants