Time-course effects of aerobic physical training in the prevention of cigarette smoke-induced COPD

Author(s):Show less -

Toledo-Arruda, Alessandra C. ^[1] ; Vieira, Rodolfo P. ^{[2, 3]} ; Guarnier, Flavia A. ^[4] ; Suehiro, Camila L. ^[1] ; Caleman-Neto, Agostinho ^[1] ; Olivo, Clarice R. ^[1] ; Arantes, Petra M. M. ^[1] ; Almeida, Francine M. ^[1] ; Lopes, Fernanda D. T. Q. S. ^[1] ; Ramos, Ercy M. C. ^[5] ; Cecchini, Rubens ^[4] ; Lin, Chin Jia ^[6] ; Martins, Milton Arruda ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Clin Med, Sao Paulo - Brazil

^[2] Nove de Julho Univ, Lab Pulm & Exercise Immunol, Sao Paulo - Brazil

^[3] Univ Brasil, Sch Med Sci Humanitas, Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Paulo - Brazil

^[4] Univ Estadual Londrina, Dept Pathol, Londrina - Brazil

^[5] State Univ Sao Paulo, Dept Physiotherapy, Presidente Prudente - Brazil

^[6] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Applied Physiology; v. 123, n. 3, p. 674-683, SEP 2017.
• Web of Science Citations: 7

Abstract

A previous study by our group showed that regular exercise training (ET) attenuated pulmonary injury in an experimental model of chronic exposure to cigarette smoke (CS) in mice, but the time-course effects of the mechanisms involved in this protection remain poorly understood. We evaluated the temporal effects of regular ET in an experimental model of chronic CS exposure. Male C57BL/6 mice were divided into four groups: Control (sedentary + air), Exercise (aerobic training + air), Smoke (sedentary + smoke), and Smoke + Exercise (aerobic training + smoke). Mice were exposed to CS and ET for 4, 8, or 12 wk. Exercise protected mice exposed to CS from emphysema and reductions in tissue damping and tissue elastance after 12 wk (P < 0.01). The total number of inflammatory cells in the bronchoalveolar lavage increased in the Smoke group, mainly due to the recruitment of macrophages after 4 wk, neutrophils and lymphocytes after 8 wk, and lymphocytes and macrophages after 12 wk (P < 0.01). Exercise attenuated this increase in mice exposed to CS. The protection conferred by exercise was mainly observed after exercise adaptation. Exercise increased IL-6 and IL-10 in the quadriceps and lungs (P < 0.05) after 12 wk. Total antioxidant capacity and SOD was increased and TNF-alpha and oxidants decreased in lungs of mice exposed to CS after 12 wk (P < 0.05). The protective effects of exercise against lung injury induced by cigarette smoke exposure suggests that anti-inflammatory mediators and antioxidant enzymes play important roles in chronic obstructive pulmonary disease development mainly after the exercise adaptation. NEW \& NOTEWORTHY These experiments investigated for the first time the temporal effects of regular moderate exercise training in cigarette smoke-induced chronic obstructive pulmonary disease. We demonstrate that aerobic conditioning had a protective effect in emphysema development induced by cigarette smoke exposure. This effect was most likely secondary to an effect of exercise on oxidant-antioxidant balance and anti-inflammatory mediators. (AU)

• FAPESP's process: 09/53904-9 - Effects of environment and lifestyle on asthma and chronic obstructive pulmonary disease: studies with experimental animals and people with asthma
• Grantee: Milton de Arruda Martins
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
• Grantee: Rodolfo de Paula Vieira
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 12/09932-0 - Effects of regular aerobic exercise in mice exposed to cigarette smoke: temporal profile of the inflammatory response and oxidative stress
• Grantee: Alessandra Choqueta de Toledo
• Support type: Scholarships in Brazil - Post-Doctorate