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Effects of environment and lifestyle on asthma and chronic obstructive pulmonary disease: studies with experimental animals and people with asthma

Abstract

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are very important health problems. The purpose of this project is to study mechanisms related to environmental and lifestyle influences involved in the modulation of inflammation, hyperresponsiveness and pulmonary remodeling in asthma and COPD. We will study experimental models of chronic allergic pulmonary inflammation in mice and guinea pigs and murine models of COPD induced by exposure to cigarette smoke and to administration of elastase. We will use experimental models of stress, physical training, exposure to atmospheric pollution, administration of endotoxin and cigarette smoke. We will study pulmonary mechanics, pulmonary responsiveness to contractile agonists, inflammatory cell profile of bronchoalveolar lavage fluid (BAL), levels of cytokines and other inflammatory mediators in BAL and pulmonary tissue, using ELISA and immunohistochemistry and perform histologic evaluation of pulmonary tissue, measurements of pulmonary remodeling, and molecular biology techniques to evaluate the expression of certain genes. We will develop an equipment to expose experimental animals to cigarette smoke. We will study, in adults with persistent asthma, the effects of regular exercise in asthma control, in the severity of airway inflammation, psychosocial factors and quality of life. We will study the mechanisms of Exercise-Induced Bronchospasm (EIB) in children with clinically stable persistent asthma, evaluating quality of life scores and airway inflammation measured with induced sputum and breath condensate of expired air in asthmatic children with and without EIB. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Study demonstrates positive effects of physical activity on lung diseases 

Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES MENDES, FELIPE A.; TEIXEIRA, RENATA NAKATA; MARTINS, MILTON A.; CUKIER, ALBERTO; STELMACH, RAFAEL; MEDEIROS, WLADIMIR MUSETTI; CARVALHO, CELSO R. F. The relationship between heart rate and VO2 in moderate-to-severe asthmatics. JOURNAL OF ASTHMA, JULY 2019. Web of Science Citations: 0.
SUEHIRO, CAMILA LIYOKO; DE TOLEDO-ARRUDA, ALESSANDRA CHOQUETA; VIEIRA, RODOLFO DE PAULA; DE ALMEIDA, FRANCINE MARIA; OLIVO, CLARICE ROSA; MARTINS, MILTON DE ARRUDA; LIN, CHIN JIA. A possible association between fructose consumption and pulmonary emphysema. SCIENTIFIC REPORTS, v. 9, JUN 27 2019. Web of Science Citations: 0.
DE GENARO, ISABELLA SANTOS; DE ALMEIDA, FRANCINE MARIA; HIZUME-KUNZLER, DEBORAH CAMARGO; MORIYA, HENRIQUE TAKACHI; SILVA, RONALDO APARECIDO; GONCALVES CRUZ, JOAO CARLOS; LOPES, RENAN BOEIRA; RIGHETTI, RENATO FRAGA; VIEIRA, RODOLFO DE PAULA; SAIKI, MITIKO; MARTINS, MILTON ARRUDA; LOPES CALVO TIBERIO, IOLANDA DE FATIMA; ARANTES-COSTA, FERNANDA MAGALHAES; SARAIVA-ROMANHOLO, BEATRIZ MANGUEIRA. Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice. SCIENTIFIC REPORTS, v. 8, AUG 22 2018. Web of Science Citations: 2.
TOLEDO-ARRUDA, ALESSANDRA C.; VIEIRA, RODOLFO P.; GUARNIER, FLAVIA A.; SUEHIRO, CAMILA L.; CALEMAN-NETO, AGOSTINHO; OLIVO, CLARICE R.; ARANTES, PETRA M. M.; ALMEIDA, FRANCINE M.; LOPES, FERNANDA D. T. Q. S.; RAMOS, ERCY M. C.; CECCHINI, RUBENS; LIN, CHIN JIA; MARTINS, MILTON ARRUDA. Time-course effects of aerobic physical training in the prevention of cigarette smoke-induced COPD. Journal of Applied Physiology, v. 123, n. 3, p. 674-683, SEP 2017. Web of Science Citations: 7.
SILVA, R. A.; ALMEIDA, F. M.; OLIVO, C. R.; SARAIVA-ROMANHOLO, B. M.; MARTINS, M. A.; CARVALHO, C. R. F. Exercise reverses OVA-induced inhibition of glucocorticoid receptor and increases anti-inflammatory cytokines in asthma. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 26, n. 1, p. 82-92, JAN 2016. Web of Science Citations: 5.
FRANCA-PINTO, ANDREZZA; MENDES, FELIPE A. R.; DE CARVALHO-PINTO, REGINA MARIA; AGONDI, ROSANA CAMARA; CUKIER, ALBERTO; STELMACH, RAFAEL; SARAIVA-ROMANHOLO, BEATRIZ M.; KALIL, JORGE; MARTINS, MILTON A.; GIAVINA-BIANCHI, PEDRO; CARVALHO, CELSO R. F. Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial. THORAX, v. 70, n. 8, p. 732-739, AUG 2015. Web of Science Citations: 46.
DA SILVA, RONALDO APARECIDO; ALMEIDA, FRANCINE MARIA; OLIVO, CLARICE ROSA; SARAIVA-ROMANHOLO, BEATRIZ MANGUEIRA; PERINI, ADENIR; MARTINS, MILTON ARRUDA; FERNANDES CARVALHO, CELSO RICARDO. Comparison of the Effects of Aerobic Conditioning Before and After Pulmonary Allergic Inflammation. Inflammation, v. 38, n. 3, p. 1229-1238, JUN 2015. Web of Science Citations: 3.
SILVA, R. A.; ALMEIDA, F. M.; OLIVO, C. R.; SARAIVA-ROMANHOLO, B. M.; MARTINS, M. A.; CARVALHO, C. R. F. Airway remodeling is reversed by aerobic training in a murine model of chronic asthma. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 25, n. 3, p. e258-e266, JUN 2015. Web of Science Citations: 8.
OLIVO, CLARICE R.; MIYAJI, ELIANE N.; OLIVEIRA, MARIA LEONOR S.; ALMEIDA, FRANCINE M.; LOURENCO, JULIANA D.; ABREU, RODRIGO M.; ARANTES, PETRA M. M.; LOPES, FERNANDA D. T. Q. S.; MARTINS, MILTON A. Aerobic exercise attenuates pulmonary inflammation induced by Streptococcus pneumoniae. Journal of Applied Physiology, v. 117, n. 9, p. 998-1007, NOV 1 2014. Web of Science Citations: 15.
EVARISTO, KAREN B.; SACCOMANI, MILENE G.; MARTINS, MILTON A.; CUKIER, ALBERTO; STELMACH, RAFAEL; RODRIGUES, MARCOS R.; SANTAELLA, DANILO F.; CARVALHO, CELSO R. F. Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial. BMC PULMONARY MEDICINE, v. 14, OCT 17 2014. Web of Science Citations: 4.
HIZUME, DEBORAH C.; TOLEDO, ALESSANDRA C.; MORIYA, HENRIQUE T.; SARAIVA-ROMANHOLO, BEATRIZ M.; ALMEIDA, FRANCINE M.; ARANTES-COSTA, FERNANDA M.; VIEIRA, RODOLFO P.; DOLHNIKOFF, MARISA; KASAHARA, DAVID ITIRO; MARTINS, MILTON A. Cigarette smoke dissociates inflammation and lung remodeling in OVA-sensitized and challenged mice. Respiratory Physiology & Neurobiology, v. 181, n. 2, p. 167-176, APR 30 2012. Web of Science Citations: 14.

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