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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparison of the Effects of Aerobic Conditioning Before and After Pulmonary Allergic Inflammation

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da Silva, Ronaldo Aparecido [1, 2] ; Almeida, Francine Maria [1] ; Olivo, Clarice Rosa [1] ; Saraiva-Romanholo, Beatriz Mangueira [3, 1] ; Perini, Adenir [1] ; Martins, Milton Arruda [1] ; Fernandes Carvalho, Celso Ricardo [2, 1]
Total Authors: 7
[1] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, BR-01246903 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Phys Therapy, BR-01246903 Sao Paulo, SP - Brazil
[3] Univ City Sao Paulo UNICID, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Inflammation; v. 38, n. 3, p. 1229-1238, JUN 2015.
Web of Science Citations: 3

The aim of this study is to compare the effects of aerobic conditioning (AC) before (ACBS) and after (ACAS) allergic sensitization. BALB/c mice were divided into two main groups: ACBS and ACAS. Each groups was divided into subgroups: control (nonsensitized/nontrained), AC (nonsensitized/trained), ovalbumin (OVA) (sensitized/nontrained), AC + OVA (trained/sensitized), and OVA + AC (sensitized/trained). Sensitization was induced using OVA and AC performed in treadmill (moderate intensity). We examined IgE and IgG(1) levels, eosinophil counting, expression of Th1 (interleukin (IL)-2, IFN-alpha) and Th2 cytokines (IL-4, IL-5, IL-13), IL-10, vascular endothelial growth factor (VEGF), and airway remodeling. IgE and IgG(1) were decreased only when exercise was performed before sensitization (ACBS); however, there was a decrease of eosinophils, Th2 cytokines, VEGF, and airway remodeling and increase in IL-10 in either ACBS or ACAS groups. Our results demonstrate that aerobic conditioning reduces Th2 response before and after sensitization by increasing IL-10 while the production of anaphylactic antibodies is reduced only when exercise is performed before sensitization. (AU)

FAPESP's process: 09/53904-9 - Effects of environment and lifestyle on asthma and chronic obstructive pulmonary disease: studies with experimental animals and people with asthma
Grantee:Milton de Arruda Martins
Support type: Research Projects - Thematic Grants