Comparison of the Effects of Aerobic Conditioning Before and After Pulmonary Allergic Inflammation

Autor(es)

da Silva, Ronaldo Aparecido ^{[1, 2]} ; Almeida, Francine Maria ^[1] ; Olivo, Clarice Rosa ^[1] ; Saraiva-Romanholo, Beatriz Mangueira ^{[3, 1]} ; Perini, Adenir ^[1] ; Martins, Milton Arruda ^[1] ; Fernandes Carvalho, Celso Ricardo ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, BR-01246903 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Dept Phys Therapy, BR-01246903 Sao Paulo, SP - Brazil

^[3] Univ City Sao Paulo UNICID, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inflammation; v. 38, n. 3, p. 1229-1238, JUN 2015.
• Citações Web of Science: 3

Resumo

The aim of this study is to compare the effects of aerobic conditioning (AC) before (ACBS) and after (ACAS) allergic sensitization. BALB/c mice were divided into two main groups: ACBS and ACAS. Each groups was divided into subgroups: control (nonsensitized/nontrained), AC (nonsensitized/trained), ovalbumin (OVA) (sensitized/nontrained), AC + OVA (trained/sensitized), and OVA + AC (sensitized/trained). Sensitization was induced using OVA and AC performed in treadmill (moderate intensity). We examined IgE and IgG(1) levels, eosinophil counting, expression of Th1 (interleukin (IL)-2, IFN-alpha) and Th2 cytokines (IL-4, IL-5, IL-13), IL-10, vascular endothelial growth factor (VEGF), and airway remodeling. IgE and IgG(1) were decreased only when exercise was performed before sensitization (ACBS); however, there was a decrease of eosinophils, Th2 cytokines, VEGF, and airway remodeling and increase in IL-10 in either ACBS or ACAS groups. Our results demonstrate that aerobic conditioning reduces Th2 response before and after sensitization by increasing IL-10 while the production of anaphylactic antibodies is reduced only when exercise is performed before sensitization. (AU)

• Processo FAPESP: 09/54420-5 - Estudo dos mecanismos induzidos pelo treinamento físico aeróbico ao longo do tempo na inflamação pulmonar e no remodelamento brônquico em um modelo murino de asma
• Beneficiário: Ronaldo Aparecido da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/53904-9 - Efeitos do ambiente e do estilo de vida sobre a asma e a doença pulmonar obstrutiva crônica: estudos experimentais e clínicos
• Beneficiário: Milton de Arruda Martins
• Modalidade de apoio: Auxílio à Pesquisa - Temático