| Texto completo | |
| Autor(es): |
da Silva, Ronaldo Aparecido
[1, 2]
;
Almeida, Francine Maria
[1]
;
Olivo, Clarice Rosa
[1]
;
Saraiva-Romanholo, Beatriz Mangueira
[3, 1]
;
Perini, Adenir
[1]
;
Martins, Milton Arruda
[1]
;
Fernandes Carvalho, Celso Ricardo
[1, 2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Lab Expt Therapeut LIM 20, BR-01246903 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Dept Phys Therapy, BR-01246903 Sao Paulo, SP - Brazil
[3] Univ City Sao Paulo UNICID, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Inflammation; v. 38, n. 3, p. 1229-1238, JUN 2015. |
| Citações Web of Science: | 3 |
| Resumo | |
The aim of this study is to compare the effects of aerobic conditioning (AC) before (ACBS) and after (ACAS) allergic sensitization. BALB/c mice were divided into two main groups: ACBS and ACAS. Each groups was divided into subgroups: control (nonsensitized/nontrained), AC (nonsensitized/trained), ovalbumin (OVA) (sensitized/nontrained), AC + OVA (trained/sensitized), and OVA + AC (sensitized/trained). Sensitization was induced using OVA and AC performed in treadmill (moderate intensity). We examined IgE and IgG(1) levels, eosinophil counting, expression of Th1 (interleukin (IL)-2, IFN-alpha) and Th2 cytokines (IL-4, IL-5, IL-13), IL-10, vascular endothelial growth factor (VEGF), and airway remodeling. IgE and IgG(1) were decreased only when exercise was performed before sensitization (ACBS); however, there was a decrease of eosinophils, Th2 cytokines, VEGF, and airway remodeling and increase in IL-10 in either ACBS or ACAS groups. Our results demonstrate that aerobic conditioning reduces Th2 response before and after sensitization by increasing IL-10 while the production of anaphylactic antibodies is reduced only when exercise is performed before sensitization. (AU) | |
| Processo FAPESP: | 09/54420-5 - Estudo dos mecanismos induzidos pelo treinamento físico aeróbico ao longo do tempo na inflamação pulmonar e no remodelamento brônquico em um modelo murino de asma |
| Beneficiário: | Ronaldo Aparecido da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 09/53904-9 - Efeitos do ambiente e do estilo de vida sobre a asma e a doença pulmonar obstrutiva crônica: estudos experimentais e clínicos |
| Beneficiário: | Milton de Arruda Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |