Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features

Author(s)

de Camargo, Anderson Alves ^[1] ; Silva de Castro, Rejane Agnelo ^[1] ; Vieira, Rodolfo P. ^{[2, 3]} ; Oliveira-Junior, Manoel Carneiro ^[1] ; de Araujo, Amanda Aparecida ^[1] ; De Angelis, Katia ^{[4, 1]} ; Rached, Samia Zahi ^[5] ; Athanazio, Rodrigo Abensur ^[5] ; Stelmach, Rafael ^[5] ; Dal Corso, Simone ^[1]

Affiliation

^[1] Univ Nove Julho UNINOVE, Programa Posgrad Ciencias Reabilitacao, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Movimento, Santos, SP - Brazil

^[3] Univ Brasil, Programa Posgrad Bioengn, Sao Paulo, SP - Brazil

^[4] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao InCor, Div Pneumol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Clinics; v. 76, 2021.
• Web of Science Citations: 0

Abstract

OBJECTIVES: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity. METHODS: This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52.5±25.6%) and 42 healthy controls (age: 44±17 years, FEV1: 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured. RESULTS: Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1β, IL-6, and tumor necrosis factor-α correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity. CONCLUSIONS: Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity. (AU)

• FAPESP's process: 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite
• Grantee: Manoel Carneiro de Oliveira Junior
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 10/09732-6 - Validity and reproducibility of an incremental step test in patients with chronic obstructive pulmonary disease
• Grantee: Simone Dal Corso
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
• Grantee: Rodolfo de Paula Vieira
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 14/01902-0 - Effects of pulmonary rehabilitation associated with respiratory physiotherapy vs. respiratory physiotherapy on exercise capacity, peripheral muscle strength, and quality of life in patients with bronchiectasis: randomized controlled trial
• Grantee: Anderson Alves de Camargo
• Support Opportunities: Scholarships in Brazil - Doctorate