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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features

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Author(s):
de Camargo, Anderson Alves [1] ; Silva de Castro, Rejane Agnelo [1] ; Vieira, Rodolfo P. [2, 3] ; Oliveira-Junior, Manoel Carneiro [1] ; de Araujo, Amanda Aparecida [1] ; De Angelis, Katia [4, 1] ; Rached, Samia Zahi [5] ; Athanazio, Rodrigo Abensur [5] ; Stelmach, Rafael [5] ; Dal Corso, Simone [1]
Total Authors: 10
Affiliation:
[1] Univ Nove Julho UNINOVE, Programa Posgrad Ciencias Reabilitacao, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Movimento, Santos, SP - Brazil
[3] Univ Brasil, Programa Posgrad Bioengn, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao InCor, Div Pneumol, Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Clinics; v. 76, 2021.
Web of Science Citations: 0
Abstract

OBJECTIVES: To compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity. METHODS: This study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49 +/- 15 years, forced expiratory volume in 1 second {[}FEV1]: 52.5 +/- 25.6%) and 42 healthy controls (age: 44 +/- 17 years, FEV1: 95.9 +/- 14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured. RESULTS: Compared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p <0 .001) . The inflammatory markers IL-10, IL-6, and tumor necrosis factor-alpha correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity. CONCLUSIONS: Adults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity. (AU)

FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 10/09732-6 - Validity and reproducibility of an incremental step test in patients with chronic obstructive pulmonary disease
Grantee:Simone Dal Corso
Support type: Regular Research Grants
FAPESP's process: 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite
Grantee:Manoel Carneiro de Oliveira Junior
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/01902-0 - Effects of pulmonary rehabilitation associated with respiratory physiotherapy vs. respiratory physiotherapy on exercise capacity, peripheral muscle strength, and quality of life in patients with bronchiectasis: randomized controlled trial
Grantee:Anderson Alves de Camargo
Support type: Scholarships in Brazil - Doctorate