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Effect of low level laser therapy in experimental models of pulmonary chronic diseases

Abstract

Currently asthma and Chronic Obstructive Pulmonary Disease (COPD) have a high prevalence and a high economic and social cost. In this context, several experimental models have been proposed, aiming to advance knowledge about the pathophysiological processes of asthma and COPD, as well as the discovery of new therapeutic options. Therapy with Low Power Laser (LBP) is a relatively new effective therapy, with very low cost and no side effects. In this project we aim to study some parameters in animals with asthma and COPD undergoing therapy with LBP. The protocol used for the induction of asthma will be administered OVA subcutaneously (days 0 and 14) and intranasal OVA (three times / day for five weeks) or HDM intranasally (on days 0, 7, 14, 21, 28, 35 and 42). On days 43 (OVA) and 50 (HDM), animals will be sacrificed for morphologic and functional analysis of the lung. The protocol used for the induction of COPD is inhaling C57BL/6 mice for 60 days (2 times / day) with cigarette smoke. On day 61, animals will be sacrificed for morphologic and functional analysis of the lung. In both models, we will study functional and structural parameters, such as the release of cytokines and chemokines (IL-4, IL-5, IL-10, IL-13, MCP-1, TNF-±, IL-1², IL-6 and IL-10. We will also evaluate the participation of the transcription factors STAT6, GATA3 and STAT4 and NF-ºB (intact and phosphorylated), MMP-9 and MMP-12, TIMP-1 and TIMP-2 and the evaluation lung mechanics and airway hyperresponsiveness in both experimental models will be performed. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE BRITO, AURILEIA APARECIDA; DA SILVEIRA, ELAINE CRISTINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; SOARES, STEPHANIE SOUZA; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; SOARES, CLARIANA RODRIGUES; SANTOS, TAWANY GONCALVES; ALVES, CINTIA ESTEFANO; HERCULANO, KARINE ZANELLA; VIEIRA, RODOLFO PAULA; LINO-DOS-SANTOS-FRANCO, ADRIANA; ALBERTINI, REGIANE; AIMBIRE, FLAVIO; DE OLIVEIRA, ANA PAULA. Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis: Relevance to cytokines secretion from lung structural cells. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 203, JAN 2020. Web of Science Citations: 0.
GARCIA, MONIQUE; SANTOS-DIAS, ALANA; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; ANDRADE-SOUZA, ADILSON SANTOS; FERREIRA, SERGIO CESAR; JONCO AQUINO-JUNIOR, JEFFERSON COMIN; ALMEIDA, FRANCINE MARIA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LIGEIRO OLIVEIRA, ANA PAULA; BAGGIO SAVIO, LUIZ EDUARDO; COUTINHO-SILVA, ROBSON; MUELLER, TOBIAS; IDZKO, MARCO; SIEPMANN, TIMO; VIEIRA, RODOLFO PAULA. Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 x 7 receptor. European Journal of Immunology, v. 49, n. 6, p. 928-939, JUN 2019. Web of Science Citations: 1.
ALMEIDA-OLIVEIRA, A. R.; AQUINO, JR., J. C. J.; ABBASI, A.; SANTOS-DIAS, A.; OLIVEIRA, JR., M. C.; ALBERCA-CUSTODIO, R. W.; RIGONATO-OLIVEIRA, N. C.; SALLEY-DIAS, L. P.; DAMACENO-RODRIGUES, N. R.; CALDINI, E. G.; ARANTES-COSTA, F. M.; LIGEIRO-OLIVEIRA, A. P.; BELVISI, M. G.; VIEIRA, R. P. Effects of Aerobic Exercise on Molecular Aspects of Asthma: Involvement of SOCS-JAK-STAT. EXERCISE IMMUNOLOGY REVIEW, v. 25, p. 98-110, 2019. Web of Science Citations: 2.
DURIGON, THOMAS STRAVINSKAS; MACKENZIE, BREANNE; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; DE ANGELIS, KATIA; MALFITANO, CHRISTIANO; DA PALMA, RENATA KELLY; GUERRA, JULIANA MORENO; DAMACENO-RODRIGUES, NILSA REGINA; CALDINI, ELIA GARCIA; DE ALMEIDA, FRANCINE MARIA; AQUINO-SANTOS, HELIDA CRISTINA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; LEAL DE OLIVEIRA, DANIELLE BRUNA; AIMBIRE, FLAVIO; LIGEIRO DE OLIVEIRA, ANA PAULA; FRANCO DE OLIVEIRA, LUIZ VICENTE; DURIGON, EDISON LUIZ; HIEMSTRA, PIETER S.; VIEIRA, RODOLFO P. Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice. JOURNAL OF INNATE IMMUNITY, v. 10, n. 4, p. 279-290, 2018. Web of Science Citations: 2.
MORAES, GABRIEL DA CUNHA; VITORETTI, LUANA BEATRIZ; DE BRITO, AURILEIA APARECIDA; ALVES, CINTIA ESTEFANO; RIGONATO DE OLIVEIRA, NICOLE CRISTINE; DIAS, ALANA DOS SANTOS; TELES MATOS, YVES SILVA; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; FRANCO OLIVEIRA, LUIS VICENTE; DA PALMA, RENATA KELLY; CANDEO, LARISSA CARBONERA; LINO-DOS-SANTOS-FRANCO, ADRIANA; RATTO TEMPESTINE HORLIANA, ANNA CAROLINA; GIMENES, JOAO ANTONIO JUNIOR; AIMBIRE, FLAVIO; VIEIRA, RODOLFO PAULA; LIGEIRO-DE-OLIVEIRA, ANA PAULA. Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018. Web of Science Citations: 2.
CANDEO, LARISSA CARBONERA; RIGONATO-OLIVEIRA, NICOLE CRISTINE; BRITO, AURILEIA APARECIDA; MARCOS, RODRIGO LABAT; FRANCA, CRISTIANE MIRANDA; SANTOS FERNANDES, KRISTIANNE PORTA; MESQUITA-FERRARI, RAQUEL AGNELLI; BUSSADORI, SANDRA KALIL; VIEIRA, RODOLFO PAULA; LINO-DOS-SANTOS-FRANCO, ADRIANA; LIGEIRO-OLIVEIRA, ANA PAULA; RATTO TEMPESTINI HORLIANA, ANNA CAROLINA. Effects of periodontitis on the development of asthma: The role of photodynamic therapy. PLoS One, v. 12, n. 11 NOV 16 2017. Web of Science Citations: 2.
DA SILVA, CRISTIANE MIRANDA; LEAL, MAYARA PERES; BROCHETTI, ROBSON ALEXANDRE; BRAGA, TARCIO; VITORETTI, LUANA BEATRIZ; SARAIVA CAMARA, NIELS OLSEN; DAMAZO, AMILCAR SABINO; LIGEIRO-DE-OLIVEIRA, ANA PAULA; CHAVANTES, MARIA CRISTINA; LINO-DOS-SANTOS-FRANCO, ADRIANA. Low Level Laser Therapy Reduces the Development of Lung Inflammation Induced by Formaldehyde Exposure. PLoS One, v. 10, n. 11 NOV 16 2015. Web of Science Citations: 19.
SCHATZMANN PERON, JEAN PIERRE; DE BRITO, AURILEIA APARECIDA; PELATTI, MAYRA; BRANDAO, WESLEY NOGUEIRA; VITORETTI, LUANA BEATRIZ; GREIFFO, FLAVIA REGINA; DA SILVEIRA, ELAINE CRISTINA; OLIVEIRA-JUNIOR, MANUEL CARNEIRO; MALUF, MARIANGELA; EVANGELISTA, LUCILA; HALPERN, SILVIO; NISENBAUM, MARCELO GIL; PERIN, PAULO; CZERESNIA, CARLOS EDUARDO; SARAIVA CAMARA, NIELS OLSEN; AIMBIRE, FLAVIO; VIEIRA, RODOLFO DE PAULA; ZATZ, MAYANA; LIGEIRO DE OLIVEIRA, ANA PAULA. Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice. PLoS One, v. 10, n. 8 AUG 31 2015. Web of Science Citations: 13.

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