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Effect of low power laser therapy (LBP) on pulmonary inflammation in an experimental model of chronic asthma: dosimetry studies

Grant number: 14/15806-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2014
Effective date (End): July 31, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Ana Paula Ligeiro de Oliveira
Grantee:Fellipe Cipriani
Home Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Associated research grant:12/16498-5 - Effect of low level laser therapy in experimental models of pulmonary chronic diseases, AP.JP

Abstract

The Asthma affects approximately 300 million individuals worldwide and it is estimated that 250,000 people will perish each year. Is considered an important economic burden with important social and economic consequences due to school evasion and costs of hospitalizations and medications. In this context, several experimental models have been proposed, aiming to advance knowledge about the pathophysiological processes of asthma, as well as the discovery of new therapeutic options. Therapy with Low Power Laser (LBP) is a relatively new effective therapy, with very low cost and no side effects. In this project we aim to study some parameters in animals with asthma undergoing therapy with LBP. The protocol used for the induction of asthma will be administered OVA subcutaneously (days 0 and 14) and intranasal OVA (three times / day for five weeks) or HDM intranasally (on days 0, 7, 14, 21, 28, 35 and 42). On days 43 (OVA) and 50 (HDM), animals will be sacrificed for morphologic and functional analysis of the lung. In these models, we will study functional and structural parameters, such as the release of cytokines and chemokines (IL-4, IL-5, IL-10 and IL-13. We will also evaluate the serum IgE levels in these animals.