A new ferrous diflunisal complex and its effects on biopools of labile iron

Autor(es)

Sihn, Luca Michael ^[1] ; de Melo, Fernando Menegatti ^[2] ; Toma, Henrique Eisi ^[2] ; Pires Serrano, Silvia Helena ^[3] ; Esposito, Breno Pannia ^[1]

Afiliação do(s) autor(es)

^[1] Lab Bioinorgan Chem & Metallodrugs, Sao Paulo - Brazil

^[2] Supramol Nanotech Lab, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Lab Bioelectrochem & Bioelectroanalyt Chem, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY; v. 51, p. 65-72, 2019.
• Citações Web of Science: 1

Resumo

Drugs bearing metal-coordinating moieties can alter biological metal distribution. In this work, a complex between iron(II) and diflunisal was prepared in the solid state, exhibiting the following composition: {[}Fe (diflunisal)(2)(H2O)(2)], (Fe(dif)(2)). The ability of diflunisal to alter labile pools of both plasmatic and cellular iron was investigated in this work. We found out that diflunisal does not increase the levels of redox-active iron in plasma of iron overloaded patients. However, diflunisal efficiently carries iron into HeLa or HepG2 cells, inducing an iron-catalyzed oxidative stress. (AU)

• Processo FAPESP: 16/03709-9 - Modulação dos níveis e da reatividade do ferro fisiológico por novos quelantes naturais ou bifuncionais: possíveis aplicações na saúde humana
• Beneficiário: Breno Pannia Esposito
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/24725-4 - Química supramolecular e nanotecnologia
• Beneficiário: Henrique Eisi Toma
• Modalidade de apoio: Auxílio à Pesquisa - Temático