A new ferrous diflunisal complex and its effects on biopools of labile iron

Author(s)

Sihn, Luca Michael ^[1] ; de Melo, Fernando Menegatti ^[2] ; Toma, Henrique Eisi ^[2] ; Pires Serrano, Silvia Helena ^[3] ; Esposito, Breno Pannia ^[1]

Affiliation

^[1] Lab Bioinorgan Chem & Metallodrugs, Sao Paulo - Brazil

^[2] Supramol Nanotech Lab, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Lab Bioelectrochem & Bioelectroanalyt Chem, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY; v. 51, p. 65-72, 2019.
• Web of Science Citations: 1

Abstract

Drugs bearing metal-coordinating moieties can alter biological metal distribution. In this work, a complex between iron(II) and diflunisal was prepared in the solid state, exhibiting the following composition: {[}Fe (diflunisal)(2)(H2O)(2)], (Fe(dif)(2)). The ability of diflunisal to alter labile pools of both plasmatic and cellular iron was investigated in this work. We found out that diflunisal does not increase the levels of redox-active iron in plasma of iron overloaded patients. However, diflunisal efficiently carries iron into HeLa or HepG2 cells, inducing an iron-catalyzed oxidative stress. (AU)

• FAPESP's process: 16/03709-9 - Modulation of the levels and reactivity of physiological iron by mean of new natural or bifunctional chelators: possible applications in human health
• Grantee: Breno Pannia Esposito
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/24725-4 - Supramolecular chemistry and nanotechnology
• Grantee: Henrique Eisi Toma
• Support Opportunities: Research Projects - Thematic Grants