| Texto completo | |
| Autor(es): |
Rui Seabra Ferreira Jr
;
Luciana Curtolo de Barros
[2]
;
Luciana Patrícia Fernandes Abbade
[3]
;
Silvia Regina Catharino Sartori Barraviera
[4]
;
Maria Regina Cavariani Silvares
[5]
;
Leticia Gomes de Pontes
;
Lucilene Delazari dos Santos
;
Benedito Barraviera
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases; v. 23, 2017-07-06. |
| Resumo | |
Abstract Hemostatic and adhesive agents date back to World War II, when homologous fibrin sealant came onto scene. Considering that infectious diseases can be transmitted via human blood, a new heterologous fibrin sealant was standardized in the 1990s. Its components were a serine protease (a thrombin-like enzyme) extracted from the venom of Crotalus durissus terrificus snakes and a fibrinogen-rich cryoprecipitate extracted from the blood of Bubalus bubalis buffaloes. This new bioproduct has been used as a coagulant, sealant, adhesive and recently as a candidate scaffold for mesenchymal stem cells and bone and cartilage repair. This review discusses the composition of a new heterologous fibrin sealant, and cites published articles related to its preclinical applications aiming at repairing nervous system traumas and regenerating bone marrow. Finally, we present an innovative safety trial I/II that found the product to be a safe and clinically promising candidate for treating chronic venous ulcers. A multicenter clinical trial, phase II/III, with a larger number of participants will be performed to prove the efficacy of an innovative biopharmaceutical product derived from animal venom. (AU) | |
| Processo FAPESP: | 09/53846-9 - EMU: aquisição de cromatógrafo líquido de alta eficiência (CLAE) preparativo para purificação e isolamento de serinoproteinases para produção do selante de fibrina |
| Beneficiário: | Benedito Barraviera |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 12/08101-8 - Imageamento in vivo da regeneração nervosa após reimplante de raízes motoras com selante de fibrina fluo-marcado associado com células tronco mesenquimais |
| Beneficiário: | Rui Seabra Ferreira Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/13299-7 - Identificação de biomarcadores moleculares prognósticos e diagnósticos de cicatrização no exsudato inflamatório de úlceras venosas crônicas antes e após o tratamento com selante de fibrina |
| Beneficiário: | Lucilene Delazari dos Santos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |