Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis

Autor(es)

Priscila Larcher LONGO ^[1] ; Hilana Paula Carillo ARTESE ^[2] ; Marianade Sousa RABELO ^[3] ; Dione KAWAMOTO ^[4] ; Adriana Moura FOZ ^[5] ; Giuseppe Alexandre ROMITO ^[6] ; Sérgio Atala DIB ^[7] ; Marcia Pinto Alves MAYER ^[8]

Afiliação do(s) autor(es)

^[1] University of São Paulo. Institute of Biomedical Sciences. Department of Microbiology - Brasil

^[2] University of São Paulo. School of Dentistry. Department of Stomatology - Brasil

^[3] University of São Paulo. School of Dentistry. Department of Stomatology - Brasil

^[4] University of São Paulo. Institute of Biomedical Sciences. Department of Microbiology - Brasil

^[5] University of São Paulo. School of Dentistry. Department of Stomatology - Brasil

^[6] University of São Paulo. School of Dentistry. Department of Stomatology - Brasil

^[7] Federal University of São Paulo. School of Medicine. Department of Endocrinology - Brasil

^[8] University of São Paulo. Institute of Biomedical Sciences. Department of Microbiology - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Oral Science; v. 22, n. 2, p. 103-108, 2014-04-00.

Resumo

Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear. Objective: This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis. Material and Methods: Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions: Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups. (AU)

• Processo FAPESP: 11/18618-5 - Análise da diversidade da microbiota subgengival e perfil de citocinas séricas e de fluido gengival relacionados ao controle glicêmico de indivíduos com Diabetes Mellitus tipo II
• Beneficiário: Marcia Pinto Alves Mayer
• Modalidade de apoio: Auxílio à Pesquisa - Regular