Update: Biological and Chemical Aspects of Senna spectabilis

Autor(es)

Denise M. Selegato ; Afif F. Monteiro ; Natália C. Vieira ; Patrícia Cardoso ; Victor D. Pavani ; Vanderlan S. Bolzani ; Ian Castro-Gamboa

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 28, n. 3, p. -, Mar. 2017.

Resumo

Senna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigations have shown that S. spectabilis produces over 40 constituents from different biosynthetic pathways, including piperidine alkaloids, pentacyclic terpenoids and anthraquinones, displaying antiproliferative, antitumoral and antifungal activities. Moreover, studies have also been conducted to identify endophytic and rizhospheric microorganisms associated to S. spectabilis and their chemical composition, enabling further elucidation of cadinane sesquiterpenoids, cytochalasins, depsipeptides and dibenzopirones. This review aims to provide an updated summary of the main features of S. spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and its associated microorganisms. (AU)

• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/05935-0 - Co-cultura de micro-organismos isolados da rizosfera de Senna spectabilis visando a produção de metabólitos bioativos
• Beneficiário: Denise Medeiros Selegato
• Linha de fomento: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 11/50816-1 - A rizosfera de Senna spectabilis: estudo das interações planta/microrganismos utilizando ferramentas metabolômicas
• Beneficiário: Ian Castro-Gamboa
• Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Regular