Oral antibacterial effect of chlorhexidine treatments and professional prophylaxis in children

Autor(es)

Thiago Cruvinel Silva ^[1] ; Thaís Marchini Oliveira Valarelli ^[2] ; Vivien Thiemy Sakai ^[3] ; Vanessa Tessarolli ^[4] ; Maria Aparecida de Andrade Moreira Machado ^[5]

Afiliação do(s) autor(es)

^[1] University of São Paulo. Bauru School of Dentistry. Department of Pediatric Dentistry, Orthodontics, and Public Health - Brasil

^[2] University of São Paulo. Bauru School of Dentistry. Department of Pediatric Dentistry, Orthodontics, and Public Health - Brasil

^[3] Alfenas Federal University. School of Dentistry. Department of Clinic and Surgery - Brasil

^[4] University of São Paulo. Bauru School of Dentistry. Department of Pediatric Dentistry, Orthodontics, and Public Health - Brasil

^[5] University of São Paulo. Bauru School of Dentistry. Department of Pediatric Dentistry, Orthodontics, and Public Health - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Braz. J. Oral Sci.; v. 12, n. 2, p. 132-137, 2013-06-00.

Resumo

AIM: The primary aim of this longitudinal study was to evaluate additional effects of 4-week chlorhexidine digluconate (CHX) gel treatments to control Aggregatibacter actinomycetemcomitans counts in children after professional dental prophylaxis. Porphyromonas gingivalis and Streptococcus mutans counts were also determined to evaluate the secondary effects of anti-plaque treatments on microbial shifts. METHODS: Twenty-six children with A. actinomycetemcomitans counts >4 log10/mL of saliva and/or Quigley-Hein plaque index >3.0 were enrolled in this study. Patients were randomly assigned to groups GI (placebo gel), GII (0.5% CHX gel), GIII (1% CHX gel), and GIV (2% CHX gel). Four sessions of treatment were performed during 4 weeks after a session of professional dental prophylaxis. Real-Time polymerase chain reaction (PCR) was used to determine viable microorganism counts in non-stimulated whole saliva samples collected at baseline, one week, one month and three months after interruption of treatments. RESULTS: A reduction of all bacterial counts was detected after the 3-month follow-up in all groups. Lower counts of P. gingivalis were achieved from 1 week on after treatments. The 2% CHX concentration seemed to contribute to lower A. actinomycetemcomitans levels and increase S. mutans levels. CONCLUSIONS: Professional dental prophylaxis was effective to control salivary levels of A. actinomycetemcomitans, P. gingivalis and S. mutans. Additional antimicrobial effects, however, were not observed by the combination of professional dental prophylaxis and 4-week chlorhexidine gel treatments. (AU)

• Processo FAPESP: 07/00962-6 - Estudo longitudinal dos efeitos do gel de clorexidina no controle do biofilme dentário e no número de bactérias salivares
• Beneficiário: Maria Aparecida de Andrade Moreira Machado
• Modalidade de apoio: Auxílio à Pesquisa - Regular