Computational models of memory consolidation and long-term synaptic plasticity during sleep

Autor(es)

Renno-Costa, Cesar ^{[1, 2]} ; Costa da Silva, Ana Claudia ^{[3, 4, 1, 2]} ; Blanco, Wilfredo ^{[3, 1, 5]} ; Ribeiro, Sidarta ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Rio Grande do Norte, BioMe Bioinformat Multidisciplinary Environm, Natal, RN - Brazil

^[2] Univ Fed Rio Grande do Norte, Digital Metropolis Inst, Natal, RN - Brazil

^[3] Univ Fed Rio Grande do Norte, Brain Inst, Natal, RN - Brazil

^[4] Univ Fed Paraiba, Joao Pessoa, Paraiba - Brazil

^[5] State Univ Rio Grande do Norte, Natal, RN - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROBIOLOGY OF LEARNING AND MEMORY; v. 160, n. SI, p. 32-47, APR 2019.
• Citações Web of Science: 0

Resumo

The brain stores memories by persistently changing the connectivity between neurons. Sleep is known to be critical for these changes to endure. Research on the neurobiology of sleep and the mechanisms of long-term synaptic plasticity has provided data in support of various theories of how brain activity during sleep affects long-term synaptic plasticity. The experimental findings - and therefore the theories - are apparently quite contradictory, with some evidence pointing to a role of sleep in the forgetting of irrelevant memories, whereas other results indicate that sleep supports the reinforcement of the most valuable recollections. A unified theoretical framework is in need. Computational modeling and simulation provide grounds for the quantitative testing and comparison of theoretical predictions and observed data, and might serve as a strategy to organize the rather complicated and diverse pool of data and methodologies used in sleep research. This review article outlines the emerging progress in the computational modeling and simulation of the main theories on the role of sleep in memory consolidation. (AU)

• Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
• Beneficiário: Oswaldo Baffa Filho
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs