Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis

Autor(es)

Barreta, Amilcar ^[1] ; Sarian, Luis Otavio ^[1] ; Ferracini, Amanda Canato ^[2] ; Eloy Costa, Larissa Bastos ^[3] ; Mazzola, Priscila Gava ^[4] ; Andrade, Liliana de Angelo ^[3] ; Derchain, Sophie ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynecol, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med Sci, Postgrad Program Med Sci, BR-13083970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Sch Med Sci, Dept Pathol, BR-13083970 Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Fac Pharm, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HUMAN PATHOLOGY; v. 85, p. 72-81, MAR 2019.
• Citações Web of Science: 3

Resumo

Ovarian clear cell and endometrioid carcinomas (type I) are thought to develop from endometriosis. AR1D1A loss of expression is known to be related to the promotion of the endometriosis carcinogenesis. Despite the diverse origins and prognosis of type I and type 11 carcinomas, surgery followed by platinum-based chemotherapy is the mainstay of treatment for both. Limited knowledge about the expression of targeted therapies' biomarkers prevents the use of such markers as potential guides for tailored treatment. This study aimed to evaluate the expression of ARID1A gene and target therapies biomarkers (VEGF, PD-L1, and PARP-1) in ovarian clear cell and endometrioid carcinomas and endometriosis, and its relationship with prognosis. Forty-six ovarian clear cell and endometrioid carcinomas, and 24 endometriosis foci samples retrieved from the same surgical specimens were studied. AR1D1A, VEGF, PD-L1, and PARP-1 immunohistochemistry expression was compared in carcinomas and endometriosis with regard to the dinicopathological features and prognosis. We found that endometriosis was associated with increased rates of diagnosis of cancer in the initial stages (P = .008). Different levels of expression of all biomarkers were detected in clear cell and endometrioid carcinomas and endometriosis. However, only the VEGF expression level showed a significant increase in the carcinoma group when compared with endometriosis (P = .0002). PARP-1 overexpression correlated with worse progression-free survival (P = .03) and overall survival (P = .01). In conclusion, endometriosis and ovarian clear cell and endometrioid carcinomas exhibited ARID1A loss of expression, and VEGF, PD-L1, and PARP-1 expression. PARP-1 overexpression in clear cell and endometrioid carcinomas was associated with early recurrence and worse overall survival. (C) 2018 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/15059-8 - Avaliação de biomarcadores para detecção de neoplasia maligna em mulheres com tumor anexial
• Beneficiário: Sophie Françoise Mauricette Derchain
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/07822-4 - Análise De Biomarcadores Moleculares Associados À Quimiorresistência Mediada Por Células Tronco Tumorais De Mama
• Beneficiário: Sophie Françoise Mauricette Derchain
• Modalidade de apoio: Auxílio à Pesquisa - Regular