Metastasis inhibition in breast cancer by targeting cancer cell extravasation

Autor(es)

Cominetti, Marcia R. ^[1] ; Altei, Wanessa F. ^[2] ; Selistre-de-Araujo, Heloisa Sobreiro ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Physiol Sci, Rod Washington Luiz, Km 235 Postal Box 676, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: BREAST CANCER-TARGETS AND THERAPY; v. 11, p. 165-178, 2019.
• Citações Web of Science: 0

Resumo

The spread of cells from primary tumors toward distant tissues and organs, also known as metastasis, is responsible for most cancer-associated deaths. The metastasis cascade comprises a series of events, characterized by the displacement of tumor cells (TCs) from the primary tumor to distant organs by traveling through the bloodstream, and their subsequent colonization. The first step in metastasis involves loss of cell-cell and cell-matrix adhesions, increased invasiveness and migratory abilities, leading to intravasation of TCs into the blood or lymphatic vessels. Stationary TCs must undergo the process of epithelial-mesenchymal transition in order to achieve this migratory and invasive phenotype. Circulating tumor cells that have survived in the circulation and left the blood or lymphatic vessels will reach distant sites where they may stay dormant for many years or grow to form secondary tumors. To do this, cells need to go through the mesenchymal-epithelial transition to revert the phenotype in order to regain epithelial cell-to-cell junctions, grow and become a clinically relevant and detectable tumor mass. This work will review the main steps of the metastatic cascade and describe some strategies to inhibit metastasis by reducing cancer cell extravasation presenting recent studies in the context of breast cancer. (AU)

• Processo FAPESP: 15/24940-8 - Avaliação da eficácia de mudanças estruturais do [10]-gingerol em combinação com o quimioterápico doxorubicina para o tratamento de câncer de mama: estudos in vitro e in vivo
• Beneficiário: Márcia Regina Cominetti
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral
• Beneficiário: Heloisa Sobreiro Selistre de Araújo
• Modalidade de apoio: Auxílio à Pesquisa - Temático