Gonadal pathogenicity of an infectious bronchitis virus strain from the Massachusetts genotype

Autor(es)

Pereira, Nicole Assis ^{[1, 2]} ; Alessi, Antonio Carlos ^[3] ; Montassier, Helio Jose ^[3] ; Garcia Pereira, Ricardo Jose ^[4] ; Taniwaki, Sueli Akemi ^[5] ; Botosso, Viviane Fongaro ^[2] ; Rui, Bruno Rogerio ^[4] ; Richtzenhain, Leonardo Jose ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Av Prof Lineu Prestes 1374, BR-05508900 Sao Paulo, SP - Brazil

^[2] Inst Butantan, Lab Virol, Av Vital Brasil 1500, BR-05503900 Sao Paulo, SP - Brazil

^[3] Fac Ciencias Agr & Vet UNESP Jaboticabal, Dept Patol Vet, Via Acesso Prof Paulo Donato Castellane, BR-14884900 Jaboticabal, SP - Brazil

^[4] Univ Sao Paulo, Dept Reprod Anim, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 50, n. 1, p. 313-320, JAN 2019.
• Citações Web of Science: 0

Resumo

An outbreak of infectious bronchitis caused by the IBVPR03 strain of the Massachusetts genotype affected H-120 vaccinated laying hens in South Brazil. We investigated the cross protection of the vaccine by assessing the traqueal ciliostasis, virus recovery, and histopathological changes typically observed in the respiratory tract. Although the IBVPR03 strain is S1-genotyped as Massachusetts with a high genomic similarity to the H-120 vaccine strains, surprisingly, we found no tropism or pathogenicity to the trachea in birds infected with this strain. On the other hand, we observed ovarian and testicle lesions. Here, we show that, despite belonging in the Massachusetts genotype, the IBVPR03 pathotype differs from the expected respiratory pattern, causing instead marked histopathological changes in the gonads, so far not associated with this group. (AU)

• Processo FAPESP: 04/11040-4 - Avaliação da imunidade humoral cruzada contra estirpes heterólogas do vírus da Bronquite Infecciosa das galinhas desenvolvida nos compartimentos local e sistêmico das aves submetidas à vacinação sistemática contra esse vírus
• Beneficiário: Nicole Assis Pereira
• Modalidade de apoio: Bolsas no Brasil - Mestrado