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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Stingray (Potamotrygon rex) maturity is associated with inflammatory capacity of the venom

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Autor(es):
dos Santos, Juliane Monteiro [1] ; dos Santos, Janaina Cardoso [1] ; Marques, Elineide Eugenio [1] ; de Araujo, Gessi Carvalho [1] ; Seibert, Carla Simone [1] ; Lopes-Ferreira, Monica [2] ; Carla, Lima [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Fed Univ Tocantins, Environm Sci, Campus Palmas, Palmas - Brazil
[2] Butantan Inst, Immunoregulat Unit, Special Lab Appl Toxinol, Ctr Toxins Immuneresponse & Cell Signaling CEPID, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Toxicon; v. 163, p. 74-83, MAY 2019.
Citações Web of Science: 0
Resumo

Several studies have been carried out with venom from sting and mucus of stingrays of marine or fluvial environments to compare the toxicity of their venom. However, studies demonstrating the existence of the influence of both sex and the maturation stage of stingrays on the variability of the toxic effects of venom are still scarce. Here, we investigated whether the sex and/or the stage maturation of the Potamotrygon rex stingray influence the toxic capacity of the venom to develop acute inflammation in mice. We carried out the main toxic activities in mice using venom from female or male of young and adult stingrays. Our results described here show that the nociception is mainly induced by venom from young female stingrays. In contrast, we observed the action of venom from both sex of adult stingrays in the induction of exudative phase of inflammatory process, including vascular leakage and neutrophil infiltration. Our data illustrate that the composition of the venom of P. rex is influenced by the stage of maturity of the stingray, modulating the production of peptides and proteins capable of acting on leukocytes-endothelial interactions and favoring neutrophil infiltration to the damage tissue. (AU)

Processo FAPESP: 13/07467-1 - CeTICS - Centro de Toxinas, Imuno-Resposta e Sinalização Celular
Beneficiário:Hugo Aguirre Armelin
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs