Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos

Autor(es)

Mecina, Gustavo Franciscatti ^{[1, 2]} ; Chia, Mathias Ahii ^[3] ; Cordeiro-Araujo, Micheline Kezia ^[4] ; Bittencourt-Oliveira, Maria do Carmo ^[4] ; Varela, Rosa Maria ^[5] ; Torres, Ascension ^[5] ; Gonzalez Molinillo, Jose Maria ^[5] ; Antonio Macias, Francisco ^[5] ; Gonsalves da Silva, Regildo Marcio ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Inst Chem, Rua Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Sci Humanities & Languages Assis, Dept Biotechnol, Lab Herbal Med & Nat Prod, Ave Dom Antonio 2100, BR-19806900 Assis, SP - Brazil

^[3] Ahmadu Bello Univ, Dept Bot, Zaria 810001 - Nigeria

^[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Ciencias Biol, Piracicaba, SP - Brazil

^[5] Univ Cadiz, Sch Sci, Inst Biomol INBIO, Allelopathy Grp, Dept Organ Chem, Campus Excelencia Int 6 ceiA3, C Republ Saharaui 7, Cadiz 11510 - Spain

• Tipo de documento: Artigo Científico
• Fonte: AQUATIC TOXICOLOGY; v. 211, p. 81-91, JUN 2019.
• Citações Web of Science: 0

Resumo

The excessive proliferation of toxin producing cyanobacteria constitutes a significant health risk to the environment and humans. This is due to the contamination of potable water and accumulation of cyanotoxins in plant and animal tissues. As a means of controlling bloom forming cyanobacteria, secondary metabolites with pro-oxidative activities from plants are used to treat water bodies contaminated with cyanobacterial blooms and their associated toxins. The objective of the present study was to evaluate the mechanism of action of extract, fractions and isolated flavonoids of Tridax procumbens L. on Microcystis aeruginosa (Kutzing) Kutzing. by monitoring changes in growth, oxidative stress, antioxidant response, and cyanatoxin microcystins (MCs) production. The extract, fraction 3 and the isolated flavonoids significantly reduced the cell density of the cyanobacterium. Furthermore, the extract and fraction 3 increased the production of reactive oxygen species, induced lipid peroxidation, and altered antioxidant enzyme activities of M. aeruginosa. The total MCs content of the cyanobacterium was negatively affected by the presence of the extract, fractions and isolated flavonoids. The present study show that T. procumbens has secondary metabolites that are capable of interfering with the physiology and microcystins production of M. aeruginosa. These characteristics are promising for the control of this noxious cyanobacterium in aquatic ecosystems. (AU)

• Processo FAPESP: 16/19697-0 - Novas fontes de fitossanitários para o controle de cianobactérias: identificação, caracterização e isolamento dos compostos dos extratos e frações mais ativos de T. procunbens e H. vulgare
• Beneficiário: Gustavo Franciscatti Mecina
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 14/17126-0 - Caracterização de compostos de Hordeum vulgare L. (Poaceae) e Tridax procumbens L. (Asteraceae) para o desenvolvimento de método alternativo no controle das cianobactérias produtoras de cianotoxinas
• Beneficiário: Gustavo Franciscatti Mecina
• Modalidade de apoio: Bolsas no Brasil - Doutorado