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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos

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Author(s):
Mecina, Gustavo Franciscatti [1, 2] ; Chia, Mathias Ahii [3] ; Cordeiro-Araujo, Micheline Kezia [4] ; Bittencourt-Oliveira, Maria do Carmo [4] ; Varela, Rosa Maria [5] ; Torres, Ascension [5] ; Gonzalez Molinillo, Jose Maria [5] ; Antonio Macias, Francisco [5] ; Gonsalves da Silva, Regildo Marcio [1, 2]
Total Authors: 9
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Chem, Rua Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Sci Humanities & Languages Assis, Dept Biotechnol, Lab Herbal Med & Nat Prod, Ave Dom Antonio 2100, BR-19806900 Assis, SP - Brazil
[3] Ahmadu Bello Univ, Dept Bot, Zaria 810001 - Nigeria
[4] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Ciencias Biol, Piracicaba, SP - Brazil
[5] Univ Cadiz, Sch Sci, Inst Biomol INBIO, Allelopathy Grp, Dept Organ Chem, Campus Excelencia Int 6 ceiA3, C Republ Saharaui 7, Cadiz 11510 - Spain
Total Affiliations: 5
Document type: Journal article
Source: AQUATIC TOXICOLOGY; v. 211, p. 81-91, JUN 2019.
Web of Science Citations: 0
Abstract

The excessive proliferation of toxin producing cyanobacteria constitutes a significant health risk to the environment and humans. This is due to the contamination of potable water and accumulation of cyanotoxins in plant and animal tissues. As a means of controlling bloom forming cyanobacteria, secondary metabolites with pro-oxidative activities from plants are used to treat water bodies contaminated with cyanobacterial blooms and their associated toxins. The objective of the present study was to evaluate the mechanism of action of extract, fractions and isolated flavonoids of Tridax procumbens L. on Microcystis aeruginosa (Kutzing) Kutzing. by monitoring changes in growth, oxidative stress, antioxidant response, and cyanatoxin microcystins (MCs) production. The extract, fraction 3 and the isolated flavonoids significantly reduced the cell density of the cyanobacterium. Furthermore, the extract and fraction 3 increased the production of reactive oxygen species, induced lipid peroxidation, and altered antioxidant enzyme activities of M. aeruginosa. The total MCs content of the cyanobacterium was negatively affected by the presence of the extract, fractions and isolated flavonoids. The present study show that T. procumbens has secondary metabolites that are capable of interfering with the physiology and microcystins production of M. aeruginosa. These characteristics are promising for the control of this noxious cyanobacterium in aquatic ecosystems. (AU)

FAPESP's process: 16/19697-0 - New sources of phytosanitary products for the control of cyanobacteria: identification, characterization and isolation of the compounds most active of the extracts and fractions of T. procunbens and H. vulgare
Grantee:Gustavo Franciscatti Mecina
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/17126-0 - Characterization of compounds Hordeum vulgare (Poaceae) and Tridax procumbens L. (Asteraceae) for the development of alternative control method of cyanobacteria cyanotoxins producer
Grantee:Gustavo Franciscatti Mecina
Support Opportunities: Scholarships in Brazil - Doctorate