Leptin resensitisation: a reversion of leptin-resistant states

Autor(es)

Andreoli, Marfa F. ^{[1, 2]} ; Donato Jr, Jose ; Cakir, Isin ^{[3, 4]} ; Perello, Mario ^[5]

Afiliação do(s) autor(es)

^[1] Prov Buenos Aires CIC PBA, La Plata Childrens Hosp & Sci Res Commiss, Inst Dev & Paediat Res IDIP, Lab Expt Neurodev, La Plata, Buenos Aires - Argentina

^[2] Argentine Res Council CONICET, La Plata, Buenos Aires - Argentina

^[3] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 - USA

^[4] Vanderbilt Univ, Dept Mol Physiol & Biophys, 221 Kirkland Hall, Nashville, TN 37232 - USA

^[5] Natl Univ La Plata & Sci Res Commiss, Prov Buenos Aires CIC PBA, Argentine Res Council CONICET, Lab Neurophysiol, Multidisciplinary Inst Cell Biol, La Plata, Buenos Aires - Argentina

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Endocrinology; v. 241, n. 3, p. R81-R96, JUN 2019.
• Citações Web of Science: 4

Resumo

Leptin resistance refers to states in which leptin fails to pro mote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals. Leptin resensitisation refers to the reversion of leptin-resistant states and is associated with improvement in endocrine and metabolic disturbances commonly observed in obesity and a sustained decrease of plasma leptin levels, possibly below a critical threshold level. In obesity, leptin resensitisation can be achieved with treatments that reduce body adiposity and leptinaemia, or with some pharmacological compounds, while physiological leptin resistance reverts spontaneously. The restoration of leptin sensitivity could be a useful strategy to treat obesity, maintain weight loss and/or reduce the recidivism rate for weight regain after dieting. This review provides an update and discussion about reversion of leptin-resistant states and modulation of the molecular mechanisms involved in each situation. (AU)

• Processo FAPESP: 17/02983-2 - Ação do hormônio do crescimento no sistema nervoso: relevância para as funções neurais e na doença
• Beneficiário: Jose Donato Junior
• Modalidade de apoio: Auxílio à Pesquisa - Temático