Acute effects of photobiomodulation therapy (PBMT) combining laser diodes, light-emitting diodes, and magnetic field in exercise capacity assessed by 6MST in patients with COPD: a crossover, randomized, and triple-blinded clinical trial

Autor(es)

Miranda, Eduardo Foschini ^[1] ; Diniz, Welton Alves ^[1] ; Nogueira Gomes, Marcos Vinicius ^[1] ; Duarte de Oliveira, Marcelo Ferreira ^{[1, 2]} ; Camillo de Carvalho, Paulo de Tarso ^[1] ; Pinto Leal-Junior, Ernesto Cesar ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Nove Julho Univ, Postgrad Program Rehabil Sci, Sao Paulo, SP - Brazil

^[2] Nove Julho Univ, Lab Phototherapy & Innovat Technol Hlth, Rua Vergueiro 235, BR-01504001 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 34, n. 4, p. 711-719, JUN 2019.
• Citações Web of Science: 0

Resumo

Chronic obstructive pulmonary disease (COPD) is characterized by dyspnea, as well as musculoskeletal and systemic manifestations. Photobiomodulation therapy (PBMT) with use of low-level laser therapy (LLLT) and/or light-emitting diode therapy (LEDT) is an electrophysical intervention that has been found to minimize or delay muscle fatigue. The aim of this study was to evaluate the acute effect of PBMT with combined use of lasers diodes, light-emitting diodes (LEDs), magnetic field on muscle performance, exercise tolerance, and metabolic variables during the 6-minute stepper test (6MST) in patients with COPD. Twenty-one patients with COPD (FEV1 46.3% predicted) completed the 6MST protocol over 2weeks, with one session per week. PBMT/magnetic field or placebo (PL) was performed before each 6MST (17 sites on each lower limb, with a dose of 30J per site, using a cluster of 12 diodes 4x905nm super-pulsed laser diodes, 4x875nm infrared LEDs, and 4x640nm red LEDs; Multi Radiance Medical, Solon, OH, USA). Patients were randomized into two groups before the test according to the treatment they would receive. Assessments were performed before the start of each protocol. The primary outcomes were oxygen uptake and number of steps, and the secondary outcome was perceived exertion (dyspnea and fatigue in the lower limbs). PBMT/magnetic field applied before 6MST significantly increased the number of steps during the cardiopulmonary exercise test when compared to the results with placebo (129.8 +/- 10.6 vs 116.1 +/- 11.5, p=0.000). PBMT/magnetic field treatment also led to a lower score for the perception of breathlessness (3.0 {[}1.0-7.0] vs 4.0 {[}2.0-8.0], p=0.000) and lower limb fatigue (2.0 {[}0.0-5.0] vs 4.0 {[}0.0-7.0], p=0.001) compared to that with placebo treatment. This study showed that the combined application of PBMT and magnetic field increased the number of steps during the 6MST and decreased the sensation of dyspnea and lower limb fatigue in patients with COPD. (AU)

• Processo FAPESP: 10/52404-0 - Laserterapia de baixa potência na fadiga muscular e recuperação muscular pós-exercício: parâmetros ideais de aplicação e efeitos em exercício de longa duração
• Beneficiário: Ernesto Cesar Pinto Leal Junior
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores