Effects of Photobiomodulation on Functionality in Wistar Rats with Sciatic Nerve Injury

Autor(es)

Andreo, Lucas ^[1] ; Soldera, Carla A. ^[2] ; Ribeiro, Beatriz Guimaraes ^[2] ; Vicente de Matos, Patrick Raoul ^[3] ; Sousa, Paola Bindes ^[3] ; de Alcantara Araujo Amorim, Weslley Wallace ^[3] ; Ratto Tempestini Horliana, Anna Carolina ^[1] ; Bussadori, Sandra Kalil ^{[1, 2]} ; Santos Fernandes, Kristianne Porta ^[1] ; Mesquita-Ferrari, Raquel Agnelli ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, Sao Paulo, SP - Brazil

^[2] UNINOVE, Postgrad Program Rehabil Sci, Sao Paulo, SP - Brazil

^[3] UNINOVE, Univ Nove Julho, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Photochemistry and Photobiology; v. 95, n. 3, p. 879-885, MAY 2019.
• Citações Web of Science: 0

Resumo

A peripheral nerve injury (PNI) can result in motor or sensory disorders. Low-level laser therapy (LLLT) has demonstrated positive results as a treatment option for PNI. Wistar rats were divided into five groups: Control, Injury, Injury + LLLTn (nerve), Injury + LLLTm (muscle) and Injury + LLLTn + m (nerve and muscle irradiation). The groups were analyzed after one, two, three and four weeks. PNI was achieved by crushing the sciatic nerve. Laser treatment (780 nm, 3.2 J) was realized over the nerve and/or tibialis anterior muscle. In gait analyses, the groups irradiated over the nerve demonstrated an improvement after two weeks. In the analysis of mechanical sensitivity, the Injury + LLLTn demonstrated a reduction after one week in comparison with Injury group; the Injury + LLLTn + m and Injury + LLLTm demonstrated an increase after two weeks in comparison with Injury group; and the irradiated groups demonstrated a reduction in nociception after four weeks in comparison with Injury group. In the analysis of muscle atrophy, the Injury + LLLTn demonstrated more muscle mass after two weeks. LLLT improves functional aspects related to gait, mechanical sensitivity and muscle mass, with better results regarding motor aspects and muscle mass when administered over the injured nerve and better results regarding sensory aspects when administered over the muscle. (AU)

• Processo FAPESP: 14/12381-1 - Análise comparativa do efeito da laserterapia prévia associada ou não ao tratamento pós sobre a modulação de citocinas inflamatórias, do estresse oxidativo e a determinação do tipo de fibra muscular após lesão aguda
• Beneficiário: Raquel Agnelli Mesquita Ferrari
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07502-1 - Efeito da laserterapia sobre a expressão gênica e a produção de citocinas, quimiocinas e fatores de crescimento envolvidos no reparo muscular
• Beneficiário: Kristianne Porta Santos Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular