Effects of Photobiomodulation on Functionality in Wistar Rats with Sciatic Nerve Injury

Author(s)

Andreo, Lucas ^[1] ; Soldera, Carla A. ^[2] ; Ribeiro, Beatriz Guimaraes ^[2] ; Vicente de Matos, Patrick Raoul ^[3] ; Sousa, Paola Bindes ^[3] ; de Alcantara Araujo Amorim, Weslley Wallace ^[3] ; Ratto Tempestini Horliana, Anna Carolina ^[1] ; Bussadori, Sandra Kalil ^{[1, 2]} ; Santos Fernandes, Kristianne Porta ^[1] ; Mesquita-Ferrari, Raquel Agnelli ^{[1, 2]}

Affiliation

^[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, Sao Paulo, SP - Brazil

^[2] UNINOVE, Postgrad Program Rehabil Sci, Sao Paulo, SP - Brazil

^[3] UNINOVE, Univ Nove Julho, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Photochemistry and Photobiology; v. 95, n. 3, p. 879-885, MAY 2019.
• Web of Science Citations: 0

Abstract

A peripheral nerve injury (PNI) can result in motor or sensory disorders. Low-level laser therapy (LLLT) has demonstrated positive results as a treatment option for PNI. Wistar rats were divided into five groups: Control, Injury, Injury + LLLTn (nerve), Injury + LLLTm (muscle) and Injury + LLLTn + m (nerve and muscle irradiation). The groups were analyzed after one, two, three and four weeks. PNI was achieved by crushing the sciatic nerve. Laser treatment (780 nm, 3.2 J) was realized over the nerve and/or tibialis anterior muscle. In gait analyses, the groups irradiated over the nerve demonstrated an improvement after two weeks. In the analysis of mechanical sensitivity, the Injury + LLLTn demonstrated a reduction after one week in comparison with Injury group; the Injury + LLLTn + m and Injury + LLLTm demonstrated an increase after two weeks in comparison with Injury group; and the irradiated groups demonstrated a reduction in nociception after four weeks in comparison with Injury group. In the analysis of muscle atrophy, the Injury + LLLTn demonstrated more muscle mass after two weeks. LLLT improves functional aspects related to gait, mechanical sensitivity and muscle mass, with better results regarding motor aspects and muscle mass when administered over the injured nerve and better results regarding sensory aspects when administered over the muscle. (AU)

• FAPESP's process: 14/12381-1 - Comparative analysis of the effect of previous laser therapy associated or not to post treatment on the modulation of inflammatory cytokines, oxidative stress and the determination of muscle fiber type after acute injury
• Grantee: Raquel Agnelli Mesquita Ferrari
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07502-1 - Effect of laser therapy on gene expression and production of cytokines, chemokines and growth factors involved in muscle repair
• Grantee: Kristianne Porta Santos Fernandes
• Support Opportunities: Regular Research Grants