Enzymatic treatment improves the antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds

Autor(es)

Peixoto Araujo, Nayara Macedo ^[1] ; Pereira, Gustavo Araujo ^[1] ; Arruda, Henrique Silvano ^[1] ; Prado, Livia Garcia ^[1] ; Tasca Gois Ruiz, Ana Lucia ^{[2, 3]} ; Eberlin, Marcos Nogueira ^[4] ; Soares de Castro, Ruann Janser ^[5] ; Pastore, Glaucia Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Sch Food Engn, Bioflavors & Bioact Cpds Lab, Dept Food Sci, Monteiro Lobato St 80, POB 13083-862, BR-13083862 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, BR-13148218 Paulinia, SP - Brazil

^[3] Univ Estadual Campinas, UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP - Brazil

^[5] Univ Estadual Campinas, UNICAMP, Sch Food Engn, Lab Food Biochem, Dept Food Sci, BR-13083862 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 18, MAR 2019.
• Citações Web of Science: 1

Resumo

We evaluated the effect of enzymatic treatment by amylase, cellulase and protease on antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds. The effect was evaluated by using an experimental mixture design. The results showed that the antioxidant activity of the seeds increased after the enzymatic treatment. The enzymatic treatment using protease and cellulase (1:1, v/v) showed the highest values of antioxidant activity due to the increase of phenolic compounds content, mainly phenolic acids. The antiproliferative activity of the extract obtained by optimum enzymatic treatment was evaluated. We found the antiproliferative activity against the tumour lineage of prostate (PC-3) and kidney (786-0) was improved after enzymatic treatment. This work provides information that may be useful in handling of functional foods and/or drugs, since the functional properties of seeds such as antioxidant and antitumor activities were improved by enzymatic treatment with protease and cellulase. (AU)

• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático