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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enzymatic treatment improves the antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds

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Author(s):
Peixoto Araujo, Nayara Macedo [1] ; Pereira, Gustavo Araujo [1] ; Arruda, Henrique Silvano [1] ; Prado, Livia Garcia [1] ; Tasca Gois Ruiz, Ana Lucia [2, 3] ; Eberlin, Marcos Nogueira [4] ; Soares de Castro, Ruann Janser [5] ; Pastore, Glaucia Maria [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Sch Food Engn, Bioflavors & Bioact Cpds Lab, Dept Food Sci, Monteiro Lobato St 80, POB 13083-862, BR-13083862 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, BR-13148218 Paulinia, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13083970 Campinas, SP - Brazil
[5] Univ Estadual Campinas, UNICAMP, Sch Food Engn, Lab Food Biochem, Dept Food Sci, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY; v. 18, MAR 2019.
Web of Science Citations: 1
Abstract

We evaluated the effect of enzymatic treatment by amylase, cellulase and protease on antioxidant and antiproliferative activities of Adenanthera pavonina L. seeds. The effect was evaluated by using an experimental mixture design. The results showed that the antioxidant activity of the seeds increased after the enzymatic treatment. The enzymatic treatment using protease and cellulase (1:1, v/v) showed the highest values of antioxidant activity due to the increase of phenolic compounds content, mainly phenolic acids. The antiproliferative activity of the extract obtained by optimum enzymatic treatment was evaluated. We found the antiproliferative activity against the tumour lineage of prostate (PC-3) and kidney (786-0) was improved after enzymatic treatment. This work provides information that may be useful in handling of functional foods and/or drugs, since the functional properties of seeds such as antioxidant and antitumor activities were improved by enzymatic treatment with protease and cellulase. (AU)

FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants