RANKL is associated with persistent primary teeth and delayed permanent tooth emergence

Autor(es):Mostrar menos -

Arid, Juliana ^[1] ; Xavier, Thais Aparecida ^[1] ; Bezerra da Silva, Raquel Assed ^[1] ; De Rossi, Andiara ^[1] ; Bezerra da Silva, Lea Assed ^[1] ; Mussolino de Queiroz, Alexandra ^[1] ; Galo, Rodrigo ^[2] ; Alves Antunes, Livia Azeredo ^[3] ; Barbosa Silva, Marcelo Jose ^[4] ; Antunes, Leonardo Santos ^[3] ; Abbasoglu, Zerrin ^[5] ; Nelson Filho, Paulo ^[1] ; Kuchler, Erika Calvano ^[1] ; Fukada, Sandra Yasuyo ^[6]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil

^[2] Fed Univ Vale Jequitinhonha & Mucuri, Dept Dent, Diamantina, MG - Brazil

^[3] Fluminense Fed Univ, Sch Dent, Dept Specif Format, Nova Friburgo, RJ - Brazil

^[4] Univ Fed Uberlandia, Inst Biomed Sci, Immunol Dept, Lab Tumor Biomarkers & Osteoimmunol, Uberlandia, MG - Brazil

^[5] Yeditepe Univ, Dept Pediat Dent, Istanbul - Turkey

^[6] Univ Sao Paulo Ribeirao Preto, Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Paediatric Dentistry; v. 29, n. 3, p. 294-300, MAY 2019.
• Citações Web of Science: 0

Resumo

Background Tooth eruption is a process that is not fully understood. Aim To evaluate whether genetic polymorphisms for RANK/RANKL/OPG are associated with delayed tooth emergence. To evaluate whether the relative expression of this genes is associated with persistent primary teeth. Design To evaluate whether genetic polymorphisms for RANK/RANKL/OPG could be involved in delayed tooth emergence, saliva samples from 160 children, aged 6-13 years old, were analysed. To test if there is correlation between gene expression of RANK/RANKL/OPG in children with delayed tooth emergence and persistent primary teeth, periapical tissue from 15 children with persistent primary teeth and from 15 control subjects were collected for qPCR analysis. Results Fifty-six children with delayed tooth emergence (35%) had at least one permanent tooth with delayed emergence. The T allele in RANKL (rs9594738) increased the risk of delayed tooth emergence (P = 0.02; OR = 1.71, 95%CI 1.09-2.75). The relative gene expression for RANKL and the ratio RANKL/OPG in children with delayed tooth emergence and persistent primary teeth were lower compared to controls (P = 0.02 and P = 0.005, respectively). Conclusions Data suggest that the polymorphism rs9594738 in RANKL is associated with delayed permanent tooth emergence. Moreover, reduced relative gene expression of RANKL in periapical tissue is associated with persistent primary teeth. (AU)

• Processo FAPESP: 15/09034-0 - Efeito da O-GlcNacilação sobre a osteoclastogênese e reabsorção óssea
• Beneficiário: Sandra Yasuyo Fukada Alves
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores