Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

RANKL is associated with persistent primary teeth and delayed permanent tooth emergence

Full text
Author(s):
Show less -
Arid, Juliana [1] ; Xavier, Thais Aparecida [1] ; Bezerra da Silva, Raquel Assed [1] ; De Rossi, Andiara [1] ; Bezerra da Silva, Lea Assed [1] ; Mussolino de Queiroz, Alexandra [1] ; Galo, Rodrigo [2] ; Alves Antunes, Livia Azeredo [3] ; Barbosa Silva, Marcelo Jose [4] ; Antunes, Leonardo Santos [3] ; Abbasoglu, Zerrin [5] ; Nelson Filho, Paulo [1] ; Kuchler, Erika Calvano [1] ; Fukada, Sandra Yasuyo [6]
Total Authors: 14
Affiliation:
[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil
[2] Fed Univ Vale Jequitinhonha & Mucuri, Dept Dent, Diamantina, MG - Brazil
[3] Fluminense Fed Univ, Sch Dent, Dept Specif Format, Nova Friburgo, RJ - Brazil
[4] Univ Fed Uberlandia, Inst Biomed Sci, Immunol Dept, Lab Tumor Biomarkers & Osteoimmunol, Uberlandia, MG - Brazil
[5] Yeditepe Univ, Dept Pediat Dent, Istanbul - Turkey
[6] Univ Sao Paulo Ribeirao Preto, Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Ribeirao Preto, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: International Journal of Paediatric Dentistry; v. 29, n. 3, p. 294-300, MAY 2019.
Web of Science Citations: 0
Abstract

Background Tooth eruption is a process that is not fully understood. Aim To evaluate whether genetic polymorphisms for RANK/RANKL/OPG are associated with delayed tooth emergence. To evaluate whether the relative expression of this genes is associated with persistent primary teeth. Design To evaluate whether genetic polymorphisms for RANK/RANKL/OPG could be involved in delayed tooth emergence, saliva samples from 160 children, aged 6-13 years old, were analysed. To test if there is correlation between gene expression of RANK/RANKL/OPG in children with delayed tooth emergence and persistent primary teeth, periapical tissue from 15 children with persistent primary teeth and from 15 control subjects were collected for qPCR analysis. Results Fifty-six children with delayed tooth emergence (35%) had at least one permanent tooth with delayed emergence. The T allele in RANKL (rs9594738) increased the risk of delayed tooth emergence (P = 0.02; OR = 1.71, 95%CI 1.09-2.75). The relative gene expression for RANKL and the ratio RANKL/OPG in children with delayed tooth emergence and persistent primary teeth were lower compared to controls (P = 0.02 and P = 0.005, respectively). Conclusions Data suggest that the polymorphism rs9594738 in RANKL is associated with delayed permanent tooth emergence. Moreover, reduced relative gene expression of RANKL in periapical tissue is associated with persistent primary teeth. (AU)

FAPESP's process: 15/09034-0 - The role of O-glycosylation on the modulation of osteoclastogenesis and bone resorption
Grantee:Sandra Yasuyo Fukada Alves
Support Opportunities: Regular Research Grants
FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
Grantee:Erika Calvano Kuchler
Support Opportunities: Research Grants - Young Investigators Grants