Advances in atom-transfer radical polymerization for drug delivery applications

Autor(es)

Rodrigues, Plinio Ribeiro ^[1] ; Vieira, Ronierik Pioli ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Chem Engn, Dept Bioproc & Mat Engn, Albert Einstein Av, BR-13083852 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN POLYMER JOURNAL; v. 115, p. 45-58, JUN 2019.
• Citações Web of Science: 4

Resumo

The availability of appropriate materials is the main requisite for the design of controlled-release drug delivery systems (DDS), such as nanoparticles, micelles, microparticles, hydrogels and bioconjugates. These delivery platforms must be biocompatible and present appropriate mechanical, physical, chemical and biological properties, allowing the desired control over drug loading and release and granting the benefits of this therapeutic administration route. Atom transfer radical polymerization (ATRP) is presently one of the most used methods of controlled polymerization, applied to synthesize well-defined functional materials and complex polymeric architectures with programmed molecular weights and low dispersity. This review features recent advances in the synthesis of DDS by ATRP, their preparation methods, characteristics and toxicity challenges due to residual metal catalysts. A brief description of controlled polymer architectures, drug loading and release mechanisms, and ATRP techniques is presented to contextualize the readers. It is noted that precise engineering of polymeric materials over molecular architecture, granted by ARTP, is being translated to customized physical properties, allowing fine control over fundamental parameters for the design of DDS. (AU)

• Processo FAPESP: 18/02508-5 - Síntese de poli(limoneno) via O-ATRP: uma proposta de aumento da massa molar e ausência de resíduos metálicos na produção de um polímero de fonte renovável
• Beneficiário: Roniérik Pioli Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Regular