HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C

Autor(es)

Tommasini Grotto, Rejane Maria ^{[1, 2]} ; Santos, Francielle Martins ^[1] ; Picelli, Natalia ^[1] ; Silva, Giovanni Faria ^[3] ; Ferrasi, Adriana Camargo ^{[3, 1]} ; Rodrigues Sarnighausen, Valeria Cristina ^[2] ; de Moura Campos Pardini, Maria Ines ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Med Botucatu, Lab Biol Mol Hemoctr, Botucatu, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Fac Ciencias Agron, Dept Bioproc & Biotecnol, Botucatu, SP - Brazil

^[3] Univ Estadual Paulista, UNESP, Fac Med, Dept Clin Med, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista da Sociedade Brasileira de Medicina Tropical; v. 52, 2019.
• Citações Web of Science: 0

Resumo

Abstract INTRODUCTION: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. METHODS: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. RESULTS: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. CONCLUSIONS: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence. (AU)

• Processo FAPESP: 14/20645-9 - Perfil dos antígenos plaquetários humanos (HPA) em pacientes com carcinoma hepatocelular infectados pelo Vírus da Hepatite C (VHC)
• Beneficiário: Francielle Martins Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica