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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C

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Author(s):
Tommasini Grotto, Rejane Maria [1, 2] ; Santos, Francielle Martins [1] ; Picelli, Natalia [1] ; Silva, Giovanni Faria [3] ; Ferrasi, Adriana Camargo [3, 1] ; Rodrigues Sarnighausen, Valeria Cristina [2] ; de Moura Campos Pardini, Maria Ines [3, 1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista, Fac Med Botucatu, Lab Biol Mol Hemoctr, Botucatu, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Fac Ciencias Agron, Dept Bioproc & Biotecnol, Botucatu, SP - Brazil
[3] Univ Estadual Paulista, UNESP, Fac Med, Dept Clin Med, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Revista da Sociedade Brasileira de Medicina Tropical; v. 52, 2019.
Web of Science Citations: 0
Abstract

Abstract INTRODUCTION: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. METHODS: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. RESULTS: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. CONCLUSIONS: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence. (AU)

FAPESP's process: 14/20645-9 - Human platelet antigens (HPA) in patients with hepatocellular carcinoma infected by Hepatitis C Virus (HCV)
Grantee:Francielle Martins Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation